Skip to main content Accessibility help
×
Home

Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients

  • Jacques Delarue (a1), Marie-Paule Guillodo (a2), Sophie Guillerm (a1), Anthony Elbaz (a3), Yanic Marty (a3) and Jacques Clèdes (a2)...

Abstract

Haemodialysis patients display an increased cardiac mortality, which may be partly related to increased sympathoadrenal activity and insulin resistance. Fish oil decreases adrenal activation induced by mental stress and has an insulin sensitizing effect in healthy subjects. Whole-body glucose metabolism after oral glucose was studied in eight haemodialysis patients before and after a 3-week oral fish oil supplementation (i.e. EPA + DHA at 1·8 g/d). Plasma glucose fluxes were traced by using [6,6-2H2]glucose infusion. Substrate oxidation was determined by using indirect calorimetry. Each patient was studied in the basal state and over the 6 h following absorption of a 1 g/kg glucose load. Energy expenditure in response to glucose re-increased over the last 2 h of the experiment (P < 0·05), which coincided with an increase in plasma catecholamines, especially epinephrine (P < 0·05), strongly suggesting a sympathoadrenal overactivity. Fish oil supplementation blunted both re-increase in thermogenic response and concomitant increase in plasma epinephrine, but not in plasma norepinephrine, over the last 2 h of the experiment. Fish oil did not alter either whole-body glucose metabolism or substrate oxidation. These data show that in haemodialysis patients, fish oil attenuates adrenal overactivity induced by oral glucose but does not modulate whole-body glucose metabolism and insulin sensitivity.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Professor Jacques Delarue, fax +33 2 98 34 78 82, email jacques.delarue@univ-brest.fr

References

Hide All
1Friedman, AN, Moe, SM, Perkins, SM, Li, Y & Watkins, BA (2006) Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. Am J Kidney Dis 47, 10641071.
2Kutner, NG, Clow, PW, Zhang, R & Aviles, X (2002) Association of fish intake and survival in a cohort of incident dialysis patients. Am J Kidney Dis 39, 10181024.
3Sarnak, MJ, Levey, AS, Schoolwerth, AC, et al. (2003) Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 108, 21542169.
4Luke, RG (1998) Chronic renal failure – a vasculopathic state. N Engl J Med 339, 841843.
5Zoccali, C, Mallamaci, F, Parlongo, S, et al. (2002) Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease. Circulation 105, 13541359.
6Hausberg, M, Kosch, M, Harmelink, P, Barenbrock, M, Hohage, H, Kisters, K, Dietl, KH & Rahn, KH (2002) Sympathetic nerve activity in end-stage renal disease. Circulation 106, 19741979.
7Klein, IH, Ligtenberg, G, Neumann, J, Oey, PL, Koomans, HA & Blankestijn, PJ (2003) Sympathetic nerve activity is inappropriately increased in chronic renal disease. J Am Soc Nephrol 14, 32393244.
8Kotanko, P (2006) Cause and consequences of sympathetic hyperactivity in chronic kidney disease. Blood Purif 24, 9599.
9Rigalleau, V & Gin, H (2005) Carbohydrate metabolism in uraemia. Curr Opin Clin Nutr Metab Care 8, 463469.
10Delarue, J, Matzinger, O, Binnert, C, Schneiter, P, Chiolero, R & Tappy, L (2003) Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab 29, 289295.
11Delarue, J, Couet, C, Cohen, R, Brechot, JF, Antoine, JM & Lamisse, F (1996) Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans. Am J Physiol 270, E353E362.
12Delarue, J, Chang-Hong, L, Cohen, R, Corporeau, C & Simon, B (2006) Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. Br J Nutr 95, 267272.
13Acheson, K, Jequier, E & Wahren, J (1983) Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest 72, 981986.
14Acheson, KJ, Ravussin, E, Wahren, J & Jequier, E (1984) Thermic effect of glucose in man. Obligatory and facultative thermogenesis. J Clin Invest 74, 15721580.
15Matsuda, M & DeFronzo, RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 14621470.
16Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497509.
17Marty, Y, Delaunay, F, Moal, J & Samain, JF (1992) Changes in the fatty acid composition of the scallop Pecten maximus (l.) during larval development. J Exp Mar Biol Ecol 163, 221234.
18Soudant, P, Chu, FLE & Marty, Y (2000) Lipid class composition of the protozoan Perkinsus marinus an oyster parasite, and its metabolism of a fluorescent phosphatidylcholine analog. Lipids 35, 13871395.
19Jequier, E, Acheson, K & Schutz, Y (1987) Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 7, 187208.
20Delarue, J, Maingourd, C, Lamisse, F, Garrigue, MA, Bagros, P & Couet, C (1994) Glucose oxidation after a peritoneal and an oral glucose load in dialyzed patients. Kidney Int 45, 11471152.
21Livesey, G & Elia, M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 47, 608628.
22Steele, R, Wall, JS, De Bodo, RC & Altszuler, N (1956) Measurement of size and turn over rate of body glucose pool by the isotope dilution method. Am J Physiol Endocrinol Metab 187, E15E24.
23De Bodo, RC, Steele, R, Altszuler, N, Dunn, A & Bishop, JS (1963) On the hormonal regulation of carbohydrate metabolism: studies with 14C glucose. Recent Prog Horm Res 19, 445448.
24Cryer, PE (1999) Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinol Metab Clin North Am 28, 495500.
25Muller, MJ, Acheson, KJ, Piolino, V, Jeanpretre, N, Burger, AG & Jequier, E (1992) Thermic effect of epinephrine: a role for endogenous insulin. Metabolism 4, 582587.
26DeRosa, MA & Cryer, PE (2004) Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation. Am J Physiol Endocrinol Metab 287, E32E41.
27Brown, MJ, Jenner, DA, Allison, DJ & Dollery, CT (1981) Variations in individual organ release of noradrenaline measured by an improved radioenzymatic technique: limitations of peripheral venous measurements in the assessment of sympathetic nervous activity. Clin Sci (Colch) 61, 585590.
28Hoeldtke, RD, Cilmi, KM, Reichard, GA Jr, Boden, G & Owen, OE (1983) Assessment of norepinephrine secretion and production. J Lab Clin Med 101, 772782.
29Delarue, J, LeFoll, C, Corporeau, C & Lucas, D (2004) N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev 44, 289299.
30Lombardo, YB & Chicco, AG (2006) Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. J Nutr Biochem 17, 113.
31Endres, S, Ghorbani, R, Kelley, VE, et al. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320, 265271.
32Delarue, J, Maingourd, C, Couet, C, Vidal, S, Bagros, P & Lamisse, F (1998) Effects of oral glucose on intermediary metabolism in continuous ambulatory peritoneal dialysis patients versus healthy subjects. Perit Dial Int 18, 505511.
33Jassal, SV, Allen, JA, Douglas, JF & Stout, RW (1998) Autonomic function in patients on continuous ambulatory peritoneal dialysis. Perit Dial Int 18, 4651.
34Svensson, M, Schmidt, EB, Jorgensen, KA & Christensen, JH (2007) The effect of n-3 fatty acids on heart rate variability in patients treated with chronic hemodialysis. J Ren Nutr 17, 243249.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed