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Effects of soya-bean protein and casein on serum cholesterol levels in rats

Published online by Cambridge University Press:  09 March 2007

Y. Nagata ,
K. Imaizumi  and
M. Sugano
Y. Nagata
Affiliation:
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuokd 812, Japan
K. Imaizumi
Affiliation:
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuokd 812, Japan
M. Sugano
Affiliation:
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuokd 812, Japan
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Abstract

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1. The effect of the soya-bean protein isolate and casein, both given 200 g/kg diet for 3–4 weeks, on serum cholesterol was compared in male rats.

2. Soya-bean protein exerted a hypocholesteraemic effect only in a cholesterol-free low-fat (10 g maize oil/kg) diet, when the lowering action appeared independent of the strain of the rat or the feeding pattern. The results obtained with diets containing cholesterol or higher levels of fats or both showed no definite pattern of response.

3. Although the decrease in serum cholesterol appeared greater in α-lipoprotiens than in β-lipoproteins, the proportion of the former to total cholesterol remained almost unchanged. The concentration of serum apo A-I was significantly lower in rats given the vegetable protein.

4. Rats given soya-bean protein excreted significantly more neutral sterols.

5. The serum amino acid pattern did not reflect the difference in dietary protein. Addition of cholesterol to the diets modified the serum aminogarm, the decrease in threonine being most marked in both protein groups.

6. This study shows that the hypocholesteraemic action of soya-bean protein is easily modified by the type of diet.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 2 , September 1980 , pp. 113 - 121
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Anderson, J. T., Grande, F. & Keys, A. (1971). Am. J. clin. Nutr. 24, 524.CrossRefGoogle Scholar
Belton, E. A. & Truswell, A. S. (1978). Proc. Nutr. Soc. 37, 12A.Google Scholar
Caroll, K. K., Giovannetti, P. M., Huff, M. W., Moase, O., Roberts, D. C. K. & Wolfe, B. M. (1978). Am. J. clin. Nutr. 31, 1312.CrossRefGoogle Scholar
Caroll, K. K. & Hamilton, R. M. G. (1975). J. Fd Sci. 40, 18.CrossRefGoogle Scholar
Caroll, K. K., Huff, M. W. & Roberts, D. C. K. (1977). In Atherosclerosis, vol. 4 pp. 445–448 [ Schettler, G., Goto, Y., Hata, Y., and Klose, G., editors]. Berlin Heidelberg, New York: Springer-Verlag.Google Scholar
Fletcher, M. J. (1968). Clinica chim. Acta 22, 393.CrossRefGoogle Scholar
Florsheim, W. H. & Gonzales, C. (1960). Proc. Soc. exp. Biol. Med. 104,618.CrossRefGoogle Scholar
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). J. biol. Chem. 226, 497.CrossRefGoogle Scholar
Fumagalli, R., Paoletti, R. & Howard, A. N. (1978). Life Sci. 22, 947.CrossRefGoogle Scholar
Garlich, J. D., Bazzano, G. & Olson, R. E. (1970). Am. J. clin. Nutr. 23, 1626.CrossRefGoogle Scholar
Gomori, G. (1942). J. Lab. clin. Med. 27, 955.Google Scholar
Hamilton, R. M. G. & Caroll, K. K. (1976). Atherosclerosis, 24 47.CrossRefGoogle Scholar
Harper, A. E. (1959). J. Nutr. 68, 405.CrossRefGoogle Scholar
Hevia, P. & Visek, W. J. (1979). J. Nutr. 109, 32.CrossRefGoogle Scholar
Huff, M. W. & Caroll, K. K. (1977). Fedn Proc. Fedn Am. Socs exp. Biol. 36, 1104.Google Scholar
Huff, M. W., Hamilton, R. M. & Caroll, K. K. (1977). Atherosclerosis 28, 187.CrossRefGoogle Scholar
Imaizumi, K., Fainaru, M. & Havel, R. J. (1978). J. Lipid Res. 19, 712.CrossRefGoogle Scholar
Jarowski, C. I. & Pytelewski, R. (1975). J. pharmac. Sci. 64, 690.CrossRefGoogle Scholar
Kim, D. N., Lee, K. T., Reiner, J. M. & Thomas, W. A. (1978). Exp. mol. Pathol. 29, 385.CrossRefGoogle Scholar
Kritchevsky, D. (1979). J. Am. Oil Chem. Soc. 56, 135.CrossRefGoogle Scholar
Kritchevsky, D., Tepper, S. A. & Story, J. A. (1978). Fedn Proc. Fedn Am. Socs exp. Biol. 37, 747.Google Scholar
Laurell, C. B. (1966). Analyt. Biochem. 15, 45.CrossRefGoogle Scholar
Malinow, M. R., McLaughlin, P., Kohler, G. O., & Livingston, A. L. (1977). Steroids 29, 105.CrossRefGoogle Scholar
Miettinen, T. A., Ahrens, E. H. Jr. & Grundy, S. M. (1965). J Lipid Res. 6, 411.CrossRefGoogle Scholar
Noseda, G., Fragiacomo, C., Bosia, C., Ramelli, F. & Sirtori, C. R. (1979). Schweiz. med. Wschr. 109, 1852.Google Scholar
Oakenfull, D. G. & Fenwick, D. E. (1978). Br. J. Nutr. 40, 299.CrossRefGoogle Scholar
Potter, J. D., Topping, D. L. & Oakenfull, D. G. (1979). Lancet i, 223.CrossRefGoogle Scholar
Raja, P. K. & Jarowski, C. I. (1975). J. pharmac. Sci. 64, 691.CrossRefGoogle Scholar
Sirtori, C. R., Agradi, E., Conti, F., Mantero, O. & Gatti, E. (1977). Lancet i, 275.CrossRefGoogle Scholar
Sirtori, C. R., Gatti, E., Mantero, O., Conti, F., Agradi, E., Tremoli, E., Sirtori, M., Fratemigo, L., Tavazzi, L, & Kritchevsky, D. (1979). Am. J. clin. Nutr. 32, 1645.CrossRefGoogle Scholar
Sperry, W. M. & Webb, M. (1950). J. biol. Chem. 187, 97.CrossRefGoogle Scholar
Sugano, M., Higuschi-Ashizawa, K., Nagata, Y. & Okita, T. (1978). J. nutr. Sci. Vitam. 24, 449.CrossRefGoogle Scholar
Sugano, M., Morioka, H. & Tkeda, I. (1977). J. Nutr. 107, 2011.CrossRefGoogle Scholar
Warnick, G. R. & Albers, J. J. (1978). J. Lipid Res. 19, 65.CrossRefGoogle Scholar
Yadav, N. R. & Liener, I. E. (1977). Nutr. Rep. int. 16, 385.Google Scholar