Skip to main content Accessibility help
×
Home

Effects of soya-bean protein and casein on serum cholesterol levels in rats

  • Y. Nagata (a1), K. Imaizumi (a1) and M. Sugano (a1)

Abstract

1. The effect of the soya-bean protein isolate and casein, both given 200 g/kg diet for 3–4 weeks, on serum cholesterol was compared in male rats.

2. Soya-bean protein exerted a hypocholesteraemic effect only in a cholesterol-free low-fat (10 g maize oil/kg) diet, when the lowering action appeared independent of the strain of the rat or the feeding pattern. The results obtained with diets containing cholesterol or higher levels of fats or both showed no definite pattern of response.

3. Although the decrease in serum cholesterol appeared greater in α-lipoprotiens than in β-lipoproteins, the proportion of the former to total cholesterol remained almost unchanged. The concentration of serum apo A-I was significantly lower in rats given the vegetable protein.

4. Rats given soya-bean protein excreted significantly more neutral sterols.

5. The serum amino acid pattern did not reflect the difference in dietary protein. Addition of cholesterol to the diets modified the serum aminogarm, the decrease in threonine being most marked in both protein groups.

6. This study shows that the hypocholesteraemic action of soya-bean protein is easily modified by the type of diet.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of soya-bean protein and casein on serum cholesterol levels in rats
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Effects of soya-bean protein and casein on serum cholesterol levels in rats
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Effects of soya-bean protein and casein on serum cholesterol levels in rats
      Available formats
      ×

Copyright

References

Hide All
Anderson, J. T., Grande, F. & Keys, A. (1971). Am. J. clin. Nutr. 24, 524.
Belton, E. A. & Truswell, A. S. (1978). Proc. Nutr. Soc. 37, 12A.
Caroll, K. K., Giovannetti, P. M., Huff, M. W., Moase, O., Roberts, D. C. K. & Wolfe, B. M. (1978). Am. J. clin. Nutr. 31, 1312.
Caroll, K. K. & Hamilton, R. M. G. (1975). J. Fd Sci. 40, 18.
Caroll, K. K., Huff, M. W. & Roberts, D. C. K. (1977). In Atherosclerosis, vol. 4 pp. 445448 [ Schettler, G., Goto, Y., Hata, Y., and Klose, G., editors]. Berlin Heidelberg, New York: Springer-Verlag.
Fletcher, M. J. (1968). Clinica chim. Acta 22, 393.
Florsheim, W. H. & Gonzales, C. (1960). Proc. Soc. exp. Biol. Med. 104,618.
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). J. biol. Chem. 226, 497.
Fumagalli, R., Paoletti, R. & Howard, A. N. (1978). Life Sci. 22, 947.
Garlich, J. D., Bazzano, G. & Olson, R. E. (1970). Am. J. clin. Nutr. 23, 1626.
Gomori, G. (1942). J. Lab. clin. Med. 27, 955.
Hamilton, R. M. G. & Caroll, K. K. (1976). Atherosclerosis, 24 47.
Harper, A. E. (1959). J. Nutr. 68, 405.
Hevia, P. & Visek, W. J. (1979). J. Nutr. 109, 32.
Huff, M. W. & Caroll, K. K. (1977). Fedn Proc. Fedn Am. Socs exp. Biol. 36, 1104.
Huff, M. W., Hamilton, R. M. & Caroll, K. K. (1977). Atherosclerosis 28, 187.
Imaizumi, K., Fainaru, M. & Havel, R. J. (1978). J. Lipid Res. 19, 712.
Jarowski, C. I. & Pytelewski, R. (1975). J. pharmac. Sci. 64, 690.
Kim, D. N., Lee, K. T., Reiner, J. M. & Thomas, W. A. (1978). Exp. mol. Pathol. 29, 385.
Kritchevsky, D. (1979). J. Am. Oil Chem. Soc. 56, 135.
Kritchevsky, D., Tepper, S. A. & Story, J. A. (1978). Fedn Proc. Fedn Am. Socs exp. Biol. 37, 747.
Laurell, C. B. (1966). Analyt. Biochem. 15, 45.
Malinow, M. R., McLaughlin, P., Kohler, G. O., & Livingston, A. L. (1977). Steroids 29, 105.
Miettinen, T. A., Ahrens, E. H. Jr. & Grundy, S. M. (1965). J Lipid Res. 6, 411.
Noseda, G., Fragiacomo, C., Bosia, C., Ramelli, F. & Sirtori, C. R. (1979). Schweiz. med. Wschr. 109, 1852.
Oakenfull, D. G. & Fenwick, D. E. (1978). Br. J. Nutr. 40, 299.
Potter, J. D., Topping, D. L. & Oakenfull, D. G. (1979). Lancet i, 223.
Raja, P. K. & Jarowski, C. I. (1975). J. pharmac. Sci. 64, 691.
Sirtori, C. R., Agradi, E., Conti, F., Mantero, O. & Gatti, E. (1977). Lancet i, 275.
Sirtori, C. R., Gatti, E., Mantero, O., Conti, F., Agradi, E., Tremoli, E., Sirtori, M., Fratemigo, L., Tavazzi, L, & Kritchevsky, D. (1979). Am. J. clin. Nutr. 32, 1645.
Sperry, W. M. & Webb, M. (1950). J. biol. Chem. 187, 97.
Sugano, M., Higuschi-Ashizawa, K., Nagata, Y. & Okita, T. (1978). J. nutr. Sci. Vitam. 24, 449.
Sugano, M., Morioka, H. & Tkeda, I. (1977). J. Nutr. 107, 2011.
Warnick, G. R. & Albers, J. J. (1978). J. Lipid Res. 19, 65.
Yadav, N. R. & Liener, I. E. (1977). Nutr. Rep. int. 16, 385.

Effects of soya-bean protein and casein on serum cholesterol levels in rats

  • Y. Nagata (a1), K. Imaizumi (a1) and M. Sugano (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.