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Effects of selenium supplementation on glycaemic control markers in healthy rodents: a systematic review and meta-analysis

Published online by Cambridge University Press:  21 October 2022

Rannapaula Lawrynhuk Urbano Ferreira ,
Ângela Waleska Freire de Sousa ,
Antonio Gouveia Oliveira ,
Adriana Augusto de Rezende Open the ORCID record for Adriana Augusto de Rezende [Opens in a new window] ,
Ricardo Ney Cobucci  and
Lucia Fatima Campos Pedrosa Open the ORCID record for Lucia Fatima Campos Pedrosa [Opens in a new window]
Rannapaula Lawrynhuk Urbano Ferreira
Affiliation:
Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN 59078-900, Brazil
Ângela Waleska Freire de Sousa
Affiliation:
Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN 59078-900, Brazil
Antonio Gouveia Oliveira
Affiliation:
Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, Brazil
Adriana Augusto de Rezende
Affiliation:
Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN 59078-900, Brazil Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, RN, Brazil
Ricardo Ney Cobucci
Affiliation:
Graduate Program of Biotechnology and Medical School, Universidade Potiguar (UnP), Anima, Natal, RN, Brazil Graduate Program in Sciences Applied to Women’s Health, Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte, Natal, RN, Brazil
Lucia Fatima Campos Pedrosa*
Affiliation:
Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN 59078-900, Brazil Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil
*
*Corresponding author: Dr L. F. C. Pedrosa, email lucia.pedrosa@ufrn.br
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Abstract

Overexposure to Se is detrimental to glucose metabolism, mainly because of its pro-oxidant effects and the overexpression of selenoproteins. This systematic review evaluated the effects of Se supplementation on glycaemic control in healthy rodents. The methodology followed the PRISMA. We searched the databases for articles published up to May 2022. The risk of bias and the methodological quality were assessed using the SYRCLE and CAMARADES. The results are presented as meta-analytic estimates of the overall standardised mean difference (SMD) and 95 % CI. Of the 2359 records retrieved, thirteen studies were included, of which eleven used sodium selenite and two used zero-valent Se nanoparticles as supplement. Nine studies were included in the meta-analysis. Generally, the risk of bias was high, and 23·1 % of the studies were of high quality. Supplementation with sodium selenite significantly increased fasting blood glucose (SMD = 2·57 (95 % CI (1·07, 4·07)), I2 = 93·5 % (P = 0·001). Subgroup analyses showed effect size was larger for interventions lasting between 21 and 28 d (SMD = 25·74 (95 % CI (2·29, 9·18)), I2 = 96·1 % (P = 0·001)) and for a dose of 864·7 μg/kg/d of sodium selenite (SMD = 10·26 (95 % CI (2·42, 18·11), I2 = 97·1 % (P = 0·010)). However, it did not affect glutathione peroxidase activity (SMD = 0·60 (95 % CI (-0·71, 1·91)), I2 = 83·2 % (P = 0·37)). The current analysis demonstrated the adverse effects of sodium selenite supplementation on glycaemic control in healthy rodents.

Keywords

Selenium supplementationGlutathione peroxidaseGlucose metabolismSelenoproteinsAnimal modelsMeta-analysis
Type
Systematic Review and Meta-Analysis
Information
British Journal of Nutrition , Volume 130 , Issue 4 , 28 August 2023 , pp. 564 - 574
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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