Blachier, F, Leclercq-Meyer, V, Marchand, J, Woussen-Colle, MC, Mathias, PC, Sener, A & Malaisse, WJ (1989 a) Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to L-arginine and L-ornithine. Biochimica et Biophysica Acta 1013, 144–151.
Blachier, F, Mourtada, A, Sener, A & Malaisse, WJ (1989 b) Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets. Endocrinology 124, 134–141.
Cynober, L (1995) Ornithine alpha-ketoglutarate. In Amino Acid Metabolism and Therapy in Health and Nutritional Disease, pp. 385–395 [Cynober, L, editor]. Boca Raton, FL: CRC Press.
Cynober, L (1999) The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care. Current Opinion in Clinical Nutrition and Metabolic Care 2, 33–37.
Cynober, L, Capeau, J & Ekindjian, OG (1986) Cultured fibroblasts as a suitable model for studying insulin action on glucose uptake. Diabète et Metabolisme 12, 308–314.
Cynober, L, Coudray-Lucas, C, De Bandt, JP, Guéchot, J, Aussel, C, Salvucci, M & Giboudeau, J (1990) Action of ornithine alpha-ketoglutarate, ornithine hydrochloride, and calcium alpha-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. Journal of the American College of Nutrition 9, 2–12.
Cynober, L, Saizy, R, Nguyen Dinh, F, Lioret, N & Giboudeau, J (1984 a) Effect of enterally administered ornithine alpha-ketoglutarate on plasma and urinary amino acid levels after burn injury. Journal of Trauma 24, 590–596.
Cynober, L, Vaubourdolle, M, Dore, A & Giboudeau, J (1984 b) Kinetics and metabolic effects of orally administered ornithine alpha-ketoglutarate in healthy subjects fed with a standardized regimen. American Journal of Clinical Nutrition 39, 514–519.
De Bandt, JP & Cynober, LA (1998) Amino acids with anabolic properties. Current Opinion in Clinical Nutrition and Metabolic Care 1, 263–272.
Gay, G, Villaume, C, Beaufrand, MJ, Felber, JP & Debry, G (1979) Effects of ornithine alphaketoglutarate on blood insulin, glucagon and amino acids in alcoholic cirrhosis. Biomedicine 30, 173–177.
Gross, R, Roye, M, Manteghetti, M, Broca, C, Hillaire-Buys, D, Masiello, P & Ribes, G (1997) Mechanisms involved in the effect of nitric oxide synthase inhibition on L-arginine-induced insulin secretion. British Journal of Pharmacology 120, 495–501.
Hoogarden, D, Nielsen, J & Larson, L (1986) Localisation and biosynthesis of polyamines in insulin-producing cells. Biochemical Journal 238, 73–74.
Krassowski, J, Rousselle, J, Maeder, E & Felber, JP (1981) The effect of ornithine-alpha-ketoglutarate on insulin and glucagon secretion in normal subjects. Acta Endocrinologica 98, 252–255.
Lacy, PE & Kostianovsky, M (1967) Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16, 35–39.
Leander, UF, Veterberg, K & Vinnars, E (1985) Nitrogen sparing effect of Ornicetil in the immediate postoperative state. Clinical biochemistry and nitrogen balance. Clinical Nutrition 4, 43–51.
Le Boucher, J, Coudray-Lucas, C, Lasnier, E, Jardel, A, Ekindjian, OG & Cynober, LA (1997) Enteral administration of ornithine alpha-ketoglutarate or arginine alpha-ketoglutarate: a comparative study of their effects on glutamine pools in burn-injured rats. Critical Care Medicine 25, 293–298.
Le Boucher, J, Farges, MC, Minet, R, Vasson, MP & Cynober, L (1999) Modulation of immune response with ornithine α-ketoglutarate in burn injury: an arginine or glutamine dependency? Nutrition 15, 773–777.
Lenzen, S, Schmidt, W, Rustenbeck, I & Panten, U (1986) 2-ketoglut tarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids. Bioscience Reports 6, 163–169.
MacDonald, M & Fahien, L (2000) Glutamate is not a messenger in insulin secretion. Journal of Biological Chemistry 275, 34025–34027.
Maechler, P & Wollheim, CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402, 685–689.
Malaisse, W (1991) Metabolic factors influencing synthesis and secretion of pancreatic islet hormones. In The Endocrine Pancreas, pp. 73–92 [Samols, E, editor]. New York: Raven Press Ltd.
Malaisse, WJ, Blachier, F, Mourtada, A, Camara, J, Albor, A, Valverde, I & Sener, A (1989 a) Stimulus-secretion coupling of arginine-induced insulin release. Metabolism of L-arginine and L-ornithine in pancreatic islets. Biochimica et Biophysica Acta 1013, 133–143.
Malaisse, WJ, Blachier, F, Mourtada, A, Camara, J, Albor, A, Valverde, I & Sener, A (1989 b) Stimulus-secretion coupling of arginine-induced insulin release: metabolism of L-arginine and L-ornithine in tumoral islet cells. Molecular and Cellular Endocrinology 67, 81–91.
Malaisse, WJ, Sener, A, Malaisse-Lagae, F, Welsh, M, Matthews, DE, Bier, DM & Hellerstrom, C (1982) The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine. Journal of Biological Chemistry 257, 8731–8737.
Marie, JC, Bailblé, D, Gylfe, E & Portha, B (2000) Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 Diabetes. Journal of Endocrinology 169, 169–176.
Minet, R, Villie, F, Marcollet, M, Meynial-Denis, D & Cynober, L (1997) Measurement of glutamine synthetase activity in rat muscle by a colorimetric assay. Clinica Chimica Acta 268, 121–132.
Moinard, C, Caldefie, F, Walrand, S, Tridon, A, Chassagne, J, Vasson, MP & Cynober, L (2002) Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines. Clinical Science (London) 102, 287–295.
Rorsman, P & Renström, E (1999) Cell biology: glutamate primes up the pump. Nature 402, 595–596.
Schmidt, HH, Warner, TD, Ishii, K, Sheng, H & Murad, F (1992) Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255, 721–723.
Sener, A, Blachier, F & Malaisse, WJ (1988) Production of urea but absence of urea cycle in pancreatic islet cells. Medicine and Science Research 16, 483–484.
Vaubourdolle, M, Cynober, L, Lioret, N, Coudray-Lucas, C, Aussel, C, Saizy, R & Giboudeau, J (1987) Influence of enterally administered ornithine alpha-ketoglutarate on hormonal patterns in burn patients. Burns 13, 349–356.
Vaubourdolle, M, Salvucci, M, Coudray-Lucas, C, Agneray, J, Cynober, L & Ekindjian, OG (1990) Action of ornithine alpha ketoglutarate on DNA synthesis by human fibroblasts. In Vitro Cellular and Developmental Biology 26, 187–192.
Welsh, N & Sjöholm, A (1988) Polyamines and insulin production in isolated mouse pancreatic islets. Biochemical Journal 252, 701–707.