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Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Published online by Cambridge University Press:  08 March 2007

Shu-Tzu Chen ,
Jiun-Rong Chen ,
Chwei-Shiun Yang ,
Sheng-Jeng Peng  and
Shyang-Hwa Ferng
Shu-Tzu Chen
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan
Jiun-Rong Chen
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan
Chwei-Shiun Yang
Affiliation:
Division of Nephrology, Cathay General Hospital, Taipei, Taiwan
Sheng-Jeng Peng
Affiliation:
Division of Nephrology, Cathay General Hospital, Taipei, Taiwan
Shyang-Hwa Ferng*
Affiliation:
Division of Nephrology, Cathay General Hospital, Taipei, Taiwan
*
*corresponding author: Dr Shyang-Hwa Ferng, fax +886 2 2737 3112, email syunei@tmu.edu.tw
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Abstract

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Clinical trials have shown that soya protein reduces the concentrations of some atherogenic lipids in subjects with normal renal function. The present study examined the effects of soya protein on serum lipid concentrations and lipoprotein metabolism in patients on hypercholesterolaemic haemodialysis. Twenty-six hypercholesterolaemic (total cholesterol ≥6·21mmol/l) patients on haemodialysis were studied in a randomized, double-blind, placebo-controlled clinical trial. After a 4-week run-in phase, the subjects were randomly assigned to two groups. Isolated soya protein or milk protein 30g was consumed daily as a beverage at breakfast or post-dialysis for 12 weeks. Soya protein substitution resulted in significant reductions in total cholesterol (17·2 (sd8·9)%), LDL-cholesterol (15·3 (sd12·5)), apo B (14·6 (sd12·1)%) and insulin (23·8 (sd18·7)%) concentrations. There were no significant changes in HDL-cholesterol or apo A-I. These results indicate that replacing part of the daily protein intake with soya protein has a beneficial effect on atherogenic lipids and favourably affects lipoprotein metabolism in hypercholesterolaemic patients undergoing haemodialysis.

Keywords

Soya proteinHaemodialysisLipoproteinsHypercholesterolaemia
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 366 - 371
Copyright
Copyright © The Nutrition Society 2006

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