Hostname: page-component-848d4c4894-pjpqr Total loading time: 0 Render date: 2024-06-24T17:54:15.640Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis

Published online by Cambridge University Press:  07 January 2011

H. S. Fraser  and
G. A. O. Alleyne
H. S. Fraser
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Kingston 7, Jamaica, West Indies
G. A. O. Alleyne
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Kingston 7, Jamaica, West Indies
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated.

2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth.

3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein.

4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls.

5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 31 , Issue 2 , March 1974 , pp. 113 - 124
Copyright
Copyright © The Nutrition Society 1974

References

REFERENCES

Alleyne, G. A. O. (1967). Pediatrics, N.Y. 39, 400.Google Scholar
Alleyne, G. A. O. (1970). J. clin. Invest. 49, 943.CrossRefGoogle Scholar
Alleyne, G. A. O. & Scullard, G. H. (1969). J. clin. Invest. 48, 364.CrossRefGoogle Scholar
Baxter, J. S. & Yoffey, J. M. (1948). J. Anat. 82, 189.Google Scholar
Bignall, M. C., Elebute, O. & Lotspecih, W. D. (1968). Am. J. Physiol. 215, 289.CrossRefGoogle Scholar
Burch, H. B., Kuhlman, A. M., Skerjance, J. & Lowry, O. H. (1971). Pediatrics, N.Y. 47, 199.Google Scholar
Conway, E. J. (1957). Microdiffusion Analysis and Volumetric Error. London: Crosby, Lockwood and Son Ltd.Google Scholar
Dicker, S. E. (1950). Biochem. J. 46, 53.CrossRefGoogle Scholar
Enesco, M. & Leblond, C. P. (1962). J. Embryol. exp. Morph. 10, 530.Google Scholar
Flores, H. & Alleyne, G. A. O. (1971). Biochem. J. 123, 35.CrossRefGoogle Scholar
Flores, H., Sierralta, W. & Monckeberg, F. (1970). J. Nutr. 100, 375.CrossRefGoogle Scholar
Goldstein, L. (1971). Am. J. Physiol. 220, 213.CrossRefGoogle Scholar
Goodman, A. D., Fuisz, R. E. & Cahill, G. F. Jr (1966). J. clin. Invest. 45, 612.CrossRefGoogle Scholar
Gordillo, G., Soto, R. A., Metcoff, J., Lopez, E. & Antillon, L. G. (1957). Pediatrics, N. Y. 20, 303.Google Scholar
Huggett, A. St. G. & Nixon, D. A. (1957). Lancet ii, 368.CrossRefGoogle Scholar
Kennedy, G. C. (1958). J. Endocr. 16, 9.CrossRefGoogle Scholar
Klahr, S., Tripathy, K. & Lotero, H. (1970). Am. J. Med. 48, 325.CrossRefGoogle Scholar
Longshaw, I. D., Alleyne, G. A. O. & Pogson, C. I. (1972). J. clin. Invest. 51, 2284.CrossRefGoogle Scholar
Lotspeich, W. D. (1965). Am. J. Physiol. 208, 1135.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.CrossRefGoogle Scholar
Miller, S. A. (1969). In Mammalian Protein Metabolism Vol. 3, p. 183 [ Munro, H. N., editor]. New York and London: Academic Press.CrossRefGoogle Scholar
Munro, H. N. & Fleck, A. (1969). In Mammalian Protein Metabolism Vol. 3, p. 423 [Munro, H. N., editor]. New York and London: Academic Press.CrossRefGoogle Scholar
Priestley, G. C. & Malt, R. A. (1968). J. Cell Biol. 37, 703.CrossRefGoogle Scholar
Schneiden, H., Hendrickse, R. G. & Haigh, C. P. (1958). Trans. R. Soc. trop. Med. Hyg. 52, 169.CrossRefGoogle Scholar
Smith, R. (1959). Lancet i, 764.CrossRefGoogle Scholar
Spray, C. M. & Widdowson, E. M. (1950). Br. J. Nutr. 4, 332.CrossRefGoogle Scholar
Stern, I. & Shapiro, B. (1953). J. clin. Path. 6, 158.CrossRefGoogle Scholar
Wacker, G. R., Zarkowsky, H. S. & Burch, H. B. (1961). Am. J. Physiol. 200, 367.CrossRefGoogle Scholar
Widdowson, E. M., Dickerson, J. W. T. & McCance, R. A. (1960). Br. J. Nutr. 14, 457.CrossRefGoogle Scholar
Widdowson, E. M. & McCance, R. A. (1960). Proc. R. Soc. B 152, 188.Google Scholar
Winick, M. & Noble, A. (1965). Devl Biol. 12, 451.CrossRefGoogle Scholar