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Effect of groundnut meal containing aflatoxin on Cynomolgus monkeys

Published online by Cambridge University Press:  09 March 2007

W. F. J. Cuthbertson ,
A. C. Laursen  and
D. A. H. Pratt
W. F. J. Cuthbertson
Affiliation:
Glaxo Research Ltd, Greenford, Middx.
A. C. Laursen
Affiliation:
Glaxo Research Ltd, Greenford, Middx.
D. A. H. Pratt
Affiliation:
Glaxo Research Ltd, Greenford, Middx.
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Abstract

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1. Both male and female Cynomolgus (Macaca irus) monkeys survived for 3 years without apparent ill health when fed on diets containing groundnut meal to provide up to 0·36 μg aflatoxin B1 per g diet and thus supplying a mean daily consumption of up to 2 μg aflatoxin B1 per kg body-weight. No histological changes attributable to aflatoxicosis were discovered in any of the organs from the monkeys receiving these quantities of aflatoxin.

2. Few monkeys survived for more than a month or two when given a diet containing 1·8 μg aflatoxin B1 per g, which provided about 50 μg aflatoxin B1 per kg body-weight per day.

3. No depression in growth rate nor effect on health was noted in those monkeys which survived on diets containing 1·8 μg aflatoxin B1, nor in any of the other monkeys.

4. Histological changes were observed in the livers of all monkeys receiving the diet containing 1·8 μg aflatoxin B1 per g for more than a month or two, but no abnormalities related to aflatoxicosis could be detected in any of the other organs, except for minor changes in the kidneys of two monkeys.

5. No tumours were seen in any of the monkeys, even in those surviving for 3 years on diets providing 1·8 μg aflatoxin B1/g. Thus, no conclusions can be drawn from this work as to the carcinogenicity of aflatoxin in monkeys (still less in man), because the animals were young and little is known of the duration of exposure required to demonstrate carcinogenicity in this species.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 4 , December 1967 , pp. 893 - 908
Copyright
Copyright © The Nutrition Society 1967

References

Allcroft, R. & Carnaghan, R. B. A. (1963). Chemy Ind. p. 50.Google Scholar
Allcroft, R. & Raymond, W. D. (1966). Vet. Rec. 79, 122.Google Scholar
Asao, T., Büchi, G., Abdel-Kader, M. M., Chang, S. B., Wick, E. L. & Wogan, G. N. (1963). J. Am. chem. Soc. 85, 1706.CrossRefGoogle Scholar
Asplin, F. D. & Carnaghan, R. B. A. (1961). Vet. Rec. 73, 1215.Google Scholar
Babson, A. L., Shapiro, P. O., Williams, P. A. R. & Phillips, G. E. (1962). Clinica chim. Acta 7, 199.CrossRefGoogle Scholar
Barnes, J. M. & Butler, W. H. (1964). Nature, Lond. 202, 1016.CrossRefGoogle Scholar
Blount, W. P. (1961). Turkeys 9, 52.Google Scholar
Butler, W. H. (1964). Br. J. Cancer 18, 756.CrossRefGoogle Scholar
Butler, W. H. & Barnes, J. M. (1963). Br. J. Cancer 17, 699.CrossRefGoogle Scholar
Carnaghan, R. B. A. (1965). Nature, Lond. 208, 308.CrossRefGoogle Scholar
Chang, S. B., Abdel Kader, M. M., Wick, E. L. & Wogan, G. R. (1963). Science, N. Y. 142, 1191.CrossRefGoogle Scholar
Culling, C. F. A. (1957). Handbook of Histopathological Technique. London: Butterworth.Google Scholar
De Iongh, H., Beerthuis, R. K., Vles, R. O., Barrett, C. B. & Ord, W. O. (1962). Biochim biophys. Acta 65, 548.CrossRefGoogle Scholar
Fiske, C. H. & Subbarow, Y. (1925). J. biol. Chem. 66, 375.CrossRefGoogle Scholar
Hartley, R. D., Nesbitt, B. F. & O'Kelly, J. (1963). Nature, Lond. 198, 1056.CrossRefGoogle Scholar
Hoffman, W. S. (1937). J. biol. Chem. 120, 51.CrossRefGoogle Scholar
Kelly, M. G., O'Gara, R. W., Adamson, R. H., Gadekar, M., Botkin, C. C., Reefe, W. H. & Kerber, W. T. (1966). J. natn. Cancer Inst. 36, 323.Google Scholar
Kessler, G. & Wolfman, M. (1964). Clin. Chem. 10, 686.CrossRefGoogle Scholar
Lancaster, M. C., Jenkins, F. P. & Philp, J. McL. (1961). Nature, Lond. 192, 1095.CrossRefGoogle Scholar
Loosemore, R. M. & Harding, J. D. (1961). Vet. Rec. 73, 1362.Google Scholar
Loosemore, R. M. & Markson, L. M. (1961). Vet. Rec. 73, 813.Google Scholar
Malloy, H. T. & Evelyn, K. A. (1937). J. biol. Chem. 119, 481.CrossRefGoogle Scholar
Marsh, W. H., Fingerhut, B. & Kirsch, E. (1957). Am. J. clin. Path. 28, 681.CrossRefGoogle Scholar
Nesbitt, B. F., O'Kelly, J., Sargeant, K. & Sheridan, A. (1962). Nature, Lond. 195, 1062.CrossRefGoogle Scholar
Powell, M. E. A. & Smith, M. J. (1954). J. clin. Path. 7, 245.CrossRefGoogle Scholar
Reitman, S. & Frankel, S. (1957). Am. J. clin. Path. 28, 56.CrossRefGoogle Scholar
Sargeant, K., O'Kelly, J., Carnaghan, R. B. A. & Allcroft, R. (1961). Vet. Rec. 73, 1219.Google Scholar
Sargeant, K., Sheridan, A., O'Kelly, J. & Carnaghan, R. B. A. (1961). Nature, Lond. 192, 1096.CrossRefGoogle Scholar
Tulpule, P. G., Madhavan, T. V. & Gopalan, C. (1964). Lancet i, 962.CrossRefGoogle Scholar
Weichselbaum, T. E. (1946). Am. J. clin. Path. 17, 40.CrossRefGoogle Scholar
Van der Zijden, A. S. M., Koelensmid, W. A. A. B., Boldingh, J., Barrett, C. B., Ord, W. O. & Philp, J. (1962). Nature, Lond. 195, 1060.CrossRefGoogle Scholar
Van Dorp, D. A., van der Zijden, A. S. M., Beerthuis, R. K., Sparreboom, S., Ord, W. O., de Jong, K. & Keuning, R. (1963). Recl. Trav. chim. Pays-Bas, Belge. 82, 587.CrossRefGoogle Scholar
Zall, D. M., Fisher, D. & Garner, M. O. (1956). Analyt. Chem. 28, 1665.CrossRefGoogle Scholar