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The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial

Published online by Cambridge University Press:  16 October 2023

Omid Nikpayam Open the ORCID record for Omid Nikpayam [Opens in a new window] ,
Maryam Saghafi-Asl ,
Ehsan Safaei ,
Nazgol Bahreyni ,
Vahideh Sadra  and
Parina Asgharian
Omid Nikpayam
Affiliation:
Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
Maryam Saghafi-Asl*
Affiliation:
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Science, Tabriz, Iran
Ehsan Safaei
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Nazgol Bahreyni
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Vahideh Sadra
Affiliation:
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Parina Asgharian
Affiliation:
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*
*Corresponding author: Maryam Saghafi-Asl, email saghafiaslm@gmail.com
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Abstract

The present study was carried out to evaluate the effects of okra extract supplementation on kidney function, glycaemic control, inflammation and gene expression in patients with diabetic nephropathy (DN). A total of sixty-four DN patients based on the inclusion and exclusion criteria were recruited in this triple-blind placebo-controlled randomised clinical trial. Participants were randomly allocated to receive a 125-mg capsule of dried okra extract (DOE) (n 32) or placebo (n 32) for 10 weeks. At the baseline and endpoint of the trial, kidney function, glycaemic indices, inflammation and gene expression were evaluated. Statistical analysis showed that fasting blood glucose, HbA1c and insulin resistance significantly reduced in the DOE group although between-group analysis did not show any significant difference. Also, no significant difference was observed in urine protein, urine creatinine and high-sensitivity C-reactive protein between the two groups. Furthermore, gene expression of PPAR-α, PPAR-γ, transforming growth factor-beta and Nrf-2 did not affect the end of the trial in comparison with the baseline. According to the present study, DOE did not have impressive effects on kidney function, inflammation, glycaemic management and gene expression in patients with DN.

Keywords

Diabetic nephropathyOkraGlycaemicKidney functionSupplementation
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 4 , 28 February 2024 , pp. 648 - 657
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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