Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-06-27T00:07:37.502Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary fatty acids influence the appearance of tumour necrosis factor-α receptors on adipocytes following an immune challenge

Published online by Cambridge University Press:  09 March 2007

Hilary A. MacQueen ,
Dawn Sadler  and
Christine Mattacks
Hilary A. MacQueen*
Affiliation:
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Dawn Sadler
Affiliation:
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Christine Mattacks
Affiliation:
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
*
*Corresponding author: Hilary A. MacQueen, fax +44 1908 654167, email h.a.macqueen@open.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Rats were fed from weaning on chow supplemented with suet or sunflower oil (10 % (w/w) each). The appearance of receptors for tumour necrosis factor-α on perinodal adipocytes from the popliteal depot following a subcutaneous injection of bacterial lipopolysaccharide was examined. In rats fed on sunflower oil-supplemented chow receptors appeared at a time similar to that described in rats fed unsupplemented chow, but in rats fed on chow supplemented with suet receptor appearance was significantly delayed. The popliteal adipocytes were found to contain different proportions of fatty acids as assessed by GLC. These preliminary results suggest that the fatty acid component of the diet can, by influencing the triacylglycerol-fatty acids within adipocytes, directly alter the time course of an early inflammatory immune response.

Keywords

Tumour necrosis factor-receptorsSuetSunflower oiln-6 PUFA
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 3 , September 2000 , pp. 387 - 392
Copyright
Copyright © The Nutrition Society 2000

References

Calder, PC (1997) N-3 polyunsaturated fatty acids and immune cell function.Advances in Enzyme Regulation 37, 197–237.CrossRefGoogle ScholarPubMed
Calder, PC (1998) Fat chance of immunomodulation.Immunology Today 19, 244–247.CrossRefGoogle ScholarPubMed
Chavali, SR, Zhong, WW, Utsunomiya, T and Forse, RA (1997) Decreased production of interleukin 1β, prostaglandin E2 and thromboxane B2, and elevated levels of interleukin 6 and 10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with quil-A saponin.International Archives of Allergy and Immunology 114, 153–160.CrossRefGoogle ScholarPubMed
Christie, WW (1981) The composition, structure and function of lipids in the tissues of ruminant animals. In Lipid Metabolism in Ruminant Animals, pp. 95–191 [Christie, WW, editor]. Oxford: Pergamon Press.CrossRefGoogle Scholar
Clamp, AG, Ladha, S, Clark, DC, Grimble, RF and Lund, EK (1997) The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane.Lipids 32, 179–184.CrossRefGoogle ScholarPubMed
Colby, RH and Pond, CM (1993) Site-specific differences in the responses of guinea-pig adipose tissue to changes in the fatty acid composition of the diet.Nutrition Research 13, 1203–1212.CrossRefGoogle Scholar
Del, Aguila LF, Claffey, KP and Kirwan, JP (1999) TNFα impairs insulin signalling and insulin stimulation of glucose uptake in C2C12 muscle cells.American Journal of Physiology 39, E849–E855.Google Scholar
Grimble, RF and Tappia, PS (1995) Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-α.Biochemical Society Transactions 23, 282–287.CrossRefGoogle ScholarPubMed
Khuu, Thi-Dinh KL, Demarne, Y, Nicolas, C and Lhuillery, C (1990) Effect of dietary fat on phospholipid class distribution and fatty acid composition in the rat fat cell plasma membrane.Lipids 25, 278–283.CrossRefGoogle Scholar
Kromann, A and Green, A (1980) Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950–1974.Acta Medica Scandanavica 208, 401–406.CrossRefGoogle ScholarPubMed
Lands, WEM, Inoue, M, Sugiura, Y and Okuyama, H (1982) Selective incorporation of polyunsaturated fatty acids into phosphatidylcholine by rat liver microsomes.Journal of Biological Chemistry 257, 14968–14972.CrossRefGoogle ScholarPubMed
Lowell, BB (1999) PPARγ: An essential regulator of adipogenesis and modulator of fat cell function.Cell 99, 239–242.CrossRefGoogle ScholarPubMed
MacQueen, HA, Mattacks, CA and Roberts, DR (2000) Quantitative analysis of cytokine receptors using single photon counting.Journal of Fluorescence 10, 301–305.CrossRefGoogle Scholar
MacQueen, HA and Pond, CM (1998) Immunofluorescent localisation of tumour necrosis factor-α receptors on the popliteal lymph node and the surrounding adipose tissue following a simulated immune challenge.Journal of Anatomy 192, 223–231.CrossRefGoogle ScholarPubMed
MacQueen, HA, Waights, V and Pond, CM (1999) Vascularisation in adipose depots surrounding immune-stimulated lymph nodes.Journal of Anatomy 194, 33–38.CrossRefGoogle ScholarPubMed
Maki, PA and Newberne, PM (1992) Dietary lipids and immune function.Journal of Nutrition 122, 610–614.CrossRefGoogle ScholarPubMed
Mattacks, CA and Pond, CM (1997) The effects of feeding suet-enriched chow on site-specific differences in the composition of triacylglycerol fatty acids in adipose tissue and its interactions.in vitro with lymphoid cells.British Journal of Nutrition 77, 621–643.CrossRefGoogle ScholarPubMed
Mattacks, CA and Pond, CM (1999) Interactions of noradrenalin and tumour necrosis factor-α, interleukin-4 and interleukin-6 in the control of lipolysis from adipocytes around lymph nodes.Cytokine 11, 334–346.CrossRefGoogle ScholarPubMed
Netea, MG, Kullberg, BJ, Blok, WL and van der Meer, JWM (1999) Immunomodulation by n-3 polyunsaturated fatty acids.Immunology Today 20, 103.CrossRefGoogle ScholarPubMed
Parrish, CC, Myher, JJ, Kuksis, A and Angel, A (1997) Lipid structure of rat adipocyte plasma membrane following dietary lard and fish oil.Biochimica et Biophysica Acta 1323, 253–262.CrossRefGoogle ScholarPubMed
Peraldi, P and Spiegelman, B (1998) TNFα and insulin resistance: summary and future prospects.Molecular and Cellular Biochemistry 182, 169–175.CrossRefGoogle ScholarPubMed
Pond, CM (1992) An evolutionary and functional view of mammalian adipose tissue.Proceedings of the Nutrition Society 51, 367–377.CrossRefGoogle ScholarPubMed
Pond, CM (1996) Interactions between adipose tissue and the immune system.Proceedings of the Nutrition Society 55, 111–126.CrossRefGoogle ScholarPubMed
Pond, CM (1996) Functional interpretation of the organization of mammalian adipose tissue: its relationship to the immune system.Biochemical Society Transactions 24, 393–400.CrossRefGoogle ScholarPubMed
Pond, CM (1999) Physiological specialisation of adipose tissue.Progress in Lipid Research 38, 225–248.CrossRefGoogle ScholarPubMed
Pond, CM and Mattacks, CA (1995) Interactions between adipose tissue around lymph nodes and lymphoid cells.in vitro.Journal of Lipid Research 36, 2219–2231.CrossRefGoogle ScholarPubMed
Pond, CM and Mattacks, CA (1998) In vivo evidence for the involvement of adipose tissue surrounding lymph nodes in immune responses.Immunology Letters 63, 159–167.CrossRefGoogle ScholarPubMed
Raclot, T and Groscolas, R (1993) Differential mobilization of white adipose tissue fatty acids according to chain length, unsaturation and positional isomerism.Journal of Lipid Research 34, 1515–1526.CrossRefGoogle ScholarPubMed
Raclot, T, Leray, C, Bach, AC and Groscolas, R (1995) The selective mobilization of fatty acids is not based on their positional distribution in white-fat-cell triacylglycerols.Biochemical Journal 311, 911–916.CrossRefGoogle Scholar
Raclot, T, Mioskowski E., Bach, AC and Groscolas, R (1995) Selectivity of fatty acid mobilization: a general metabolic feature of adipose tissue.American Journal of Physiology 269, R1060–R1067.Google ScholarPubMed
Sadeghi, S, Wallace, FA and Calder, PC (1999) Dietary lipids modify the cytokine response to bacterial lipopolysaccharide in mice.Immunology 96, 404–410.CrossRefGoogle ScholarPubMed
Smith, WL & Borgeat, P (1985) The eicosanoids: prostaglandins, thromboxanes, leukotrienes and hydroxy-eicosaenoic acids. In Biochemistry of Lipids and Membranes, pp. 325–360 [Vance, DE and Vance, JE, editors]. Menlo Park, CA: Benjamin Cummins Publishing Co Inc.Google Scholar
Tappia, PS, Ladha, S, Clark, DC and Grimble, RF (1997) The influence of membrane fluidity, TNF receptor binding, cAMP production and GTPase activity on macrophage cytokine production in rats fed a variety of fat diets.Molecular and Cellular Biochemistry 166, 135–143.CrossRefGoogle ScholarPubMed
Van den, Abeele, P, Declercq, W, Beyaert, R and Fiers, W (1995) Two tumour necrosis factor receptors: structure and function.Trends in Cell Biology 5, 392–399.Google Scholar
Van Zee, KJ, Kohno, T, Fischer, E, Rock, CS, Moldawer, LL and Lowry, SF (1992) Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor-α in vitro and in vivo.Proceedings of the National Academy of Sciences USA 89, 4845–4849.CrossRefGoogle ScholarPubMed