Skip to main content Accessibility help
×
Home

Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity

  • Lori A. Smolin (a1), Mary B. Grosvenor (a1), David J. Handelsman (a1) and Jo Anne Brasel (a1)

Abstract

1. Adipose tissue lipoprotein lipase (EC 3.1.1.34; AT-LPL), a rate-limiting enzyme in triglyceride storage in adipose tissue, is hormonally regulated and may be important in the maintenance of obesity.

2. In twelve obese women, AT-LPL activity was measured before weight loss, during weight loss and after 1 and 2 weeks of weight maintenance on either a high-carbohydrate or a high-protein diet.

3. When related to tissue weight, AT-LPL activity during the 2 weeks of weight maintenance was higher than the initial AT-LPL activity; there was no difference when activity was expressed per cell.

4. Changes in AT-LPL activity were not affected by diet composition. AT-LPL activity correlated with insulin levels and a change in the insulin sensitivity of AT-LPL was observed after weight loss.

Copyright

References

Hide All
Bosello, O., Cigolini, M., Battaggia, A., Ferrari, F., Micciolo, R., Olivetti, R. & Corsato, M. (1984). International Journal of Obesity 8, 213220.
Bray, G. A. & Campfield, A. (1975). Metabolism: Clinical & Experimental 24, 99117.
Brunzell, J. D. & Greenwood, M. R. C. (1983). In Biochemical Pharmacology of Metabolic Disease States, pp. 175189 [Curtis-Prior, T. B., editor]. Amsterdam: Elsevier, North Holland.
Dahms, W. T., Nilsson-Ehle, P., Garfinkel, A. S., Atkinson, R. L., Bray, G. A. & Schotz, M. C. (1981). International Journal of Obesity 5, 8184.
Dixon, W. J. [editor] (1983). BMDP Statistical Software. Berkeley, CA: University of California Press.
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). Journal of Biological Chemistry 226, 497509.
Guy-Grand, B. & Bigorie, B. (1975). Hormonal and Metabolic Research 7, 471475.
Heitanen, E. & Greenwood, M. R. C. (1977). Journal of Lipid Research 18, 480490.
Hirsch, J. & Gallian, E. (1968). Journal of Lipid Research 9, 110119.
Hollenberg, C. H. (1966). Journal of Clinical Investigation 45, 205216.
Kissebah, A. H., Vydelingum, N., Murray, R., Evans, D. J., Hartz, A. J., Kalkhoff, R. K. & Adams, P. W. (1982). Journal of Clinical Endocrinology and Metabolism 54, 254260.
Kolterman, O.G., Insel, J., Saekow, M. & Olefsky, J. M. (1980). Journal of Clinical Investigation 65, 12721284.
Lascuncion, M. A. & Herrera, E. (1983). Biochemical Journal 210, 639643.
Lithell, H. & Boberg, J. (1978). International Journal of Obesity 2, 4754.
Metropolitan Life Insurance Height & Weight Tables (1983). Statistics Bulletin 64, 9.
Nilsson-Ehle, P. & Schotz, M. C. (1976). Journal of Lipid Research 17, 536541.
Olefsky, J. M. (1976). Journal of Clinical Investigation 57, 11651172.
Pykälistö, O.J., Smith, P. H. & Brunzell, J. D. (1975). Journal of Clinical Investigation 56, 11081117.
Rebuffe-Serive, M., Basdevant, A. & Guy-Grand, B. (1983). American Journal of Clinical Nutrition 37, 974980.
Reitman, J. S., Kosmakos, F. C. & Howard, B. V. (1982). Journal of Clinical Investigation 70, 791797.
Sadur, C. N., Yost, T. J. & Eckel, R. H. (1984). Journal of Clinical Endocrinology and Metabolism 59, 11761182.
Schwartz, R. S. & Brunzell, J. D. (1978). Lancet i, 12301231.
Schwartz, R. S. & Brunzell, J. D. (1981). Journal of Clinical Investigation 67, 14251430.
Sims, E. A. H., Danforth, E., Horton, E. S., Bray, G. A., Glennon, J. A. & Salans, L. (1973). Recent Progress in Hormonal and Metabolic Research 29, 457487.
Sörbris, R., Peterson, B. G. & Nilsson-Ehle, P. (1981). European Journal of Clinical Investigation 11, 491498.
Taskinen, M. -R. & Nikkilä, E. A. (1977). Acta Medica Scandinavia 202, 399408.
Taskinen, M. -R. & Nikkilä, E. A. (1979). Diabetologia 17, 351356.
Taskinen, M. -R. & Nikkilä, E. A. (1981). Metabolism 30, 810817.
Taylor, K. G., Golton, D. J. & Holdsworth, G. (1979). Diabetologia 16, 313322.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed