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Cytokinetic and structural responses of the rat small intestine to riboflavin depletion

Published online by Cambridge University Press:  09 March 2007

E. A. Williams ,
R. D. E. Rumsey  and
H. J. Powers
E. A. Williams
Affiliation:
University Department of Paediatrics, Shefield Children's Hospital, Western Bank, Shefield SlO 2TH
R. D. E. Rumsey
Affiliation:
2Department of Biomedical Science, University of ShefieldSlO 2TN
H. J. Powers
Affiliation:
University Department of Paediatrics, Shefield Children's Hospital, Western Bank, Shefield SlO 2TH
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Abstract

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Abstract:

The impaired absorption and metabolism of Fe seen in riboflavin defiaency is attributed, at least in part, to a hyperproliferative response in the small intestine, associated with an altered morphology. Studies were conducted in female weanling Wistar rats to explore further the effect of riboflavin deficiency on the cytokinetics and structure of the small intestine. Feeding a riboflavin-deficient diet for 8 weeks from weaning resulted in a significantly lower villus number, a significant increase in villus length and an increased rate of transit of enterocytes along the villi, compared with weight-matched controls. A second experiment focused on the 3 weeks after weaning and showed that riboflavin deficiency inhibits the increase in villus number observed in control animals over this period. We suggest that riboflavin deficiency induced at weaning impairs the normal increase in villus number and that prolonged deficiency leads to an adaptive increase in length of villi and depth of crypts.

Keywords

RiboflavinCytokiaeticsSmall intestineVillus number
Type
Mineral absorption
Information
British Journal of Nutrition , Volume 75 , Issue 2 , February 1996 , pp. 315 - 324
Copyright
Copyright © The Nutrition Society 1996

References

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