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Conjugated linoleic acid increased C-reactive protein in human subjects

  • Annika Smedman (a1), Samar Basu (a1), Stefan Jovinge (a2), Gunilla Nordin Fredrikson (a2) and Bengt Vessby (a1)...

Abstract

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4·2g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0·003) compared with the control group. However, no changes in TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

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Corresponding author

*Corresponding author: Dr Annika Smedman, fax +46 18 611 79 76, email annika.smedman@pubcare.uu.se

References

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Conjugated linoleic acid increased C-reactive protein in human subjects

  • Annika Smedman (a1), Samar Basu (a1), Stefan Jovinge (a2), Gunilla Nordin Fredrikson (a2) and Bengt Vessby (a1)...

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