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Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats*

Published online by Cambridge University Press:  09 March 2007

Sahoshi Nagaoka ,
Mitsuhiro Kato ,
Yoritaka Aoyama  and
Akira Yoshida†
Sahoshi Nagaoka
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Mitsuhiro Kato
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Yoritaka Aoyama
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
Akira Yoshida†
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan
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Abstract

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1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats.

2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine.

3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic α-blocker, phenoxybenzamine.

4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 2 , September 1986 , pp. 509 - 517
Copyright
Copyright © The Nutrition Society 1986

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