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The choice of biomarkers determines the selenium status in young German vegans and vegetarians

  • Johanna Hoeflich (a1), Birgit Hollenbach (a1), Thomas Behrends (a1), Antonia Hoeg (a1), Hagen Stosnach (a1) (a2) and Lutz Schomburg (a1)...

Abstract

Daily nutrition varies considerably among individuals. The number of vegetarians is increasing continuously due to ethical, environmental, religious or other reasons. There is growing concern over their nutritional status with respect to micronutrient deficiencies. Among the essential trace elements, Se is of prime importance as it is part of the active site in selenoproteins. European soil and plants are relatively poor sources of Se, while farm animals are generally supplemented with Se in order to improve their health and avoid deficiency syndromes. We therefore wondered whether German vegetarians display a measurable Se deficiency. To this end, we compared young vegetarians (n 54) and omnivores (n 53). We assessed their Se status by measuring extracellular glutathione peroxidase 3 (GPX3) activity, and concentrations of total serum Se and circulating Se-transport protein selenoprotein P (SEPP). GPX3 activities were not different between the groups, whereas both total Se and SEPP concentrations were reduced to 79·5 and 71·2 % in vegetarians compared with omnivores. When splitting the group of vegetarians into vegans (n 26) and vegetarians consuming egg and milk products (n 28), analyses of the Se-dependent biomarkers did not reveal significant differences. We conclude that low serum Se is mirrored by circulating SEPP concentrations, but not by GPX3 activities in marginally supplied individuals. The specific dietary Se sources, divergent metabolic routes of selenomethionine v. selenocysteine and the different saturation kinetics of GPX3 and SEPP probably underlie our contradictory findings. Whether German vegetarians and vegans need to be considered as a Se-deficient group depends on the biomarker chosen.

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Corresponding author

*Corresponding author: L. Schomburg, fax +49 30 450 524922, email lutz.schomburg@charite.de

References

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1 Beckett, GJ & Arthur, JR (2005) Selenium and endocrine systems. J Endocrinol 184, 455465.
2 Hartikainen, H (2005) Biogeochemistry of selenium and its impact on food chain quality and human health. J Trace Elem Med Biol 18, 309318.
3 Rayman, MP (2009) Selenoproteins and human health: insights from epidemiological data. Biochim Biophys Acta 1790, 15331540.
4 Combs, GF Jr (2005) Current evidence and research needs to support a health claim for selenium and cancer prevention. J Nutr 135, 343347.
5 Gromadzinska, J, Reszka, E, Bruzelius, K, et al. (2008) Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur J Nutr 47, 2950.
6 Forceville, X, Vitoux, D, Gauzit, R, et al. (1998) Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients. Crit Care Med 26, 15361544.
7 Angstwurm, MW, Engelmann, L, Zimmermann, T, et al. (2007) Selenium in intensive care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 35, 118126.
8 Sakr, Y, Reinhart, K, Bloos, F, et al. (2007) Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure. Br J Anaesth 98, 775784.
9 Ashton, K, Hooper, L, Harvey, LJ, et al. (2009) Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr 89, 2025S2039S.
10 Burk, RF, Norsworthy, BK, Hill, KE, et al. (2006) Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 15, 804810.
11 Burk, RF, Hill, KE & Motley, AK (2001) Plasma selenium in specific and non-specific forms. Biofactors 14, 107114.
12 Persson-Moschos, M, Alfthan, G & Akesson, B (1998) Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium. Eur J Clin Nutr 52, 363367.
13 Rayman, MP (2008) Food-chain selenium and human health: emphasis on intake. Br J Nutr 100, 254268.
14 Combs, GF Jr (2001) Selenium in global food systems. Br J Nutr 85, 517547.
15 Arthur, JR (2003) Selenium supplementation: does soil supplementation help and why? Proc Nutr Soc 62, 393397.
16 Hollenbach, B, Morgenthaler, NG, Struck, J, et al. (2008) New assay for the measurement of selenoprotein P as a sepsis biomarker from serum. J Trace Elem Med Biol 22, 2432.
17 Flohé, L & Günzler, WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105, 114121.
18 Schomburg, L, Schweizer, U, Holtmann, B, et al. (2003) Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J 370, 397402.
19 Stosnach, H (2005) Environmental trace-element analysis using a benchtop total reflection X-ray fluorescence spectrometer. Anal Sci 21, 873876.
20 Akesson, B & Ockerman, PA (1985) Selenium status in vegans and lactovegetarians. Br J Nutr 53, 199205.
21 Kadrabova, J, Madaric, A, Kovacikova, Z, et al. (1995) Selenium status, plasma zinc, copper, and magnesium in vegetarians. Biol Trace Elem Res 50, 1324.
22 Schomburg, L & Schweizer, U (2009) Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium. Biochim Biophys Acta 1790, 14531462.
23 Xia, Y, Hill, KE, Byrne, DW, et al. (2005) Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr 81, 829834.
24 Burk, RF & Hill, KE (2005) Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr 25, 215235.

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