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The B-vitamin group and the activity of hepatic microsomal mixed-function oxidases of the growing Wistar rat

Published online by Cambridge University Press:  24 July 2007

R. Miltenberger  and
U. Oltersdorf
R. Miltenberger
Affiliation:
Institut fuer Ernaehrungswissenschaft der Justus Liebig Universitaet, D-6300 Giessen, Federal Republic of Germany
U. Oltersdorf
Affiliation:
Institut fuer Ernaehrungswissenschaft der Justus Liebig Universitaet, D-6300 Giessen, Federal Republic of Germany
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Abstract

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1. Male Wistar rats were given isoenergetic, semi-synthetic diets deficient in thiamin, riboflavin, pyrid-oxine or all the B-vitamins.

2. In rats given these deficient diets the ‘sleeping time’ induced with pentobarbital (PB) and the ‘paralysis time’ with zoxazolamine (Zz) were prolonged.

3. The tolerance effect against both drugs was nearly independent of the levels of B-vitamins in the diets.

4. In preparations from vitamin-B deficient animals the activities of the following hepatic microsomal enzymes were reduced: the aliphatic hydroxylase of PB, the aromatic hydroxylases of aniline (EC 1.14.14.1) and of Zz, the N-demethylase of aminopyrine, the UDP glucuronyltransferase (EC 2.4.1.17) of p-nitrophenol. The reactions most influenced were those of ‘type-1’ substrates, particularly those involving the hydroxylases.

5. The effects observed were caused mainly by deficiency of riboflavin and to a lesser extent of thiamin or pyridoxine.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 39 , Issue 1 , January 1978 , pp. 127 - 137
Copyright
Copyright © The Nutrition Society 1978

References

Benoehr, H. C., Franz, W. & Krisch, K. (1966). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 255, 163.CrossRefGoogle Scholar
Brodie, B. B., Burns, J. J., Mark, L. C., Lief, P. A., Bernstein, E. & Papper, E. M. (1953). J. Pharmac. exp. Ther. 109, 26.Google Scholar
Campbell, T. C. & Hayes, J. R. (1974). Pharmac. Rev. 26, 171.Google Scholar
Catz, C. S., Juchau, M. R. & Yaffe, J. S. (1970). J. Pharmac. exp. Ther. 174, 197.Google Scholar
Conney, A. H. (1967). Pharmac. Rev. 19, 317.Google Scholar
Conney, A. H., Miller, E. C. & Miller, J. A. (1956). Cancer Res. 16, 450.Google Scholar
Conney, A. H., Trousof, N. & Burns, J. J. (1960). J. Pharmac. exp. Ther. 128, 333.Google Scholar
Dickerson, J. W. T. & Walker, R. (1974). Proc. Nutr. Soc. 33, 191.CrossRefGoogle Scholar
Estabrook, R. W. (1971). In Handbuch der experimentellen Pharmakologie (Handbook of experimental pharmacology) [Born, G. V. R., Eichler, O., Farah, A., Herken, H. and Welch, A. D., editors];, Vol. 28, part 2, Concepts in biochemical pharmacology [Brodie, B. B., Gilette, J. R. and Ackerman, H. S., editors];, p. 264,Berlin-Heidelberg-New York: Springer-Verlag.Google Scholar
Gilette, J. R., Davis, D. C. & Sasame, H. A. (1972). A. Rev. Pharmac. 12, 57.CrossRefGoogle Scholar
Glatzle, D., Weiser, H., Weber, F. & Wiss, O. (1973). Int. Z. Vitam. Ern. Forsch. 43, 187.Google Scholar
Gram, T. E., Wilson, J. T. & Fouts, J. R. (1968). J. Pharmac. exp. Ther. 159, 172.Google Scholar
Grosse, W. III & Wade, A. E. (1971). J. Pharmac. exp. Ther. 176, 758.Google Scholar
Guarino, A. M., Gram, T. E., Gigon, P. L., Greene, F. E. & Gilette, J. R. (1969). Mol. Pharmac. 5, 131.Google Scholar
Higgins, G. M. & Mann, F. C. (1943). Surg. clin. N. Am. 23, 1205.Google Scholar
Hoetzel, D. (1962). Einfluss suboptimaler Versorgung mit B-Vitaminen auf die Belastungsfaehigkeit des Stoffwechsels. Hamburg: Behr.Google Scholar
Kalyanpur, S. G., Naik, S. R. & Sheth, U. K. (1968). Arch. Int. Pharmac. 173, 1.Google Scholar
Kato, R. & Tanaka, A. (1967). Jap. J. Pharmac. 17, 208.CrossRefGoogle Scholar
Kato, R., Takayanagi, M. & Oshima, T. (1969). Jap. J. Pharmac. 19, 53.CrossRefGoogle Scholar
Levy, H. A. & Di Palma, J. R. (1953). J. Pharmac. exp. Ther. 109, 377.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. Biol. Chem. 193, 265.CrossRefGoogle Scholar
Mietinnen, T. A. & Leskinen, E. (1963). Biochem. Pharmac. 12, 565.CrossRefGoogle Scholar
Moore, R. O. & Yontz, F. D. (1969). J. Nutr. 98, 235.CrossRefGoogle Scholar
Mulder, G. J. (1970). Biochem. J. 117, 319.CrossRefGoogle Scholar
Oltersdorf, U., Miltenberger, R. & Cremer, H.-D. (1977). Wld Rev. Nutr. Diet. 26, 41.CrossRefGoogle Scholar
Patel, J. M. & Pawar, S. S. (1973). Indian J. Biochem. Biophys. 10, 73.Google Scholar
Patel, J. M. & Pawar, S. S. (1974). Biochem. Pharmac. 23, 1467.CrossRefGoogle Scholar
Raica, N. & Sauberlich, H. E. (1964). Am. J. clin. Nutr. 15, 67.CrossRefGoogle Scholar
Remmer, H. (1959). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 235, 279.CrossRefGoogle Scholar
Remmer, H., Schenkman, J. B., Estabrook, R. W., Sasame, H., Gilette, J. R., Narashimhulu, S., Cooper, D. Y. & Rosenthal, O. (1966). Mol. Pharmac. 2, 187.Google Scholar
Sauberlich, H. E., Skata, J. H. & Dowdy, R. P. (1974). Laboratory tests for the assessment of nutritional status. Cleveland, Ohio: CRC Press.Google Scholar
Schenkman, J. B., Remmer, H. & Estabrook, R. W. (1967). Mol. Pharmac. 3, 113.Google Scholar
Schmid, W. (1968). Therapiewoche 18, 771.Google Scholar
Schneider, G. & Schneider, G. (1970). Z. Versuchtstierkunde 12, 6.Google Scholar
Schouten, H., van Eps, L. M. & Boudier, A. M. (1964). Clinica chim. Acta 10, 474.CrossRefGoogle Scholar
Shargel, L. & Mazel, P. (1973). Biochem. Pharmac. 22, 2365.CrossRefGoogle Scholar
Vesell, E. S. (1968). Pharmacology 1, 81.CrossRefGoogle Scholar
Vesell, E. S. (1972). In Liver and Drugs, p. 1 [Orlandi, F. and Jezequel, A. M., editors], New York, London: Academic Press.Google Scholar
von Jagow, R., Kampffmeyer, H. & Kiese, M. (1965). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 250, 261.CrossRefGoogle Scholar
Wade, A. E., Greene, F. E., Ciordia, R. H., Meadows, J. S. & Caster, W. O. (1969). Biochem. Pharmac. 18, 2288.CrossRefGoogle Scholar
Wade, A. E., Wu, B. C. & Lee, J. (1975). Biochem. Pharmac. 24, 785.CrossRefGoogle Scholar
Wattenberg, L. W. (1973). Adv. Enzyme Regul. 11, 193.CrossRefGoogle Scholar
Williams, J. R. Jr, Grantham, P. H., Yamamoto, R. S. & Weisburger, J. H. (1970). Biochem. Pharmac. 19, 2523.CrossRefGoogle Scholar