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Blood pressure and calcium intake are related tobone density in adult males

Published online by Cambridge University Press:  09 March 2007

Jill A. Metz ,
Cynthia D. Morris ,
Leslie A. Roberts ,
Michael R. McClung  and
David A. McCarron
Jill A. Metz*
Affiliation:
Department of Medicine, Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, OR, USA
Cynthia D. Morris
Affiliation:
Department of Medicine, Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, OR, USA
Leslie A. Roberts
Affiliation:
Providence Medical Center, Providence Center for Osteoporosis Research, Portland, OR, USA
Michael R. McClung
Affiliation:
Providence Medical Center, Providence Center for Osteoporosis Research, Portland, OR, USA
David A. McCarron
Affiliation:
Department of Medicine, Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, OR, USA
*
*Corresponding author: Dr Jill Metz, fax +1 503 494 5330, email metzj@ohsu.edu
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Abstract

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Based on the premise that elevated blood pressure and low bone mass have both been associated with poor Ca nutriture and disturbances in Ca metabolism, a cross-sectional study was employed to determine if blood pressure and dietary Ca intake were significantly related to bone mass. Forty-seven men between 24–77 years of age with blood pressure values ranging from normal to mildly elevated comprised the study group. Blood pressure was measured with a random-zero sphygmomanometer. Bone mineral content (BMC) and density (BMD) of the hip, spine and total body were measured with dual-photon absorptiometry. Dietary intake and physical activity were also assessed. Multiple linear regression analysis was used for statistical analysis. After adjusting for known confounding variables (age, BMI, Ca intake, and others) diastolic blood pressure was negatively related to BMC (P ≤ 0·05) and BMD (P ≤ 0·01) of the total body, trochanteric region (P < 0·01) and Ward's triangle (P < 0·05), and to BMC of the femoral neck (P < 0·05) and lumbar spine, although the latter was just shy of statistical significance (P = 0·058). Systolic blood pressure was negatively related to trochanteric BMD (P = 0·04) and BMC (P = 0·06). Ca intake was positively related to total body BMD (P = 0·005), and BMC of the lumbar spine (P = 0·05). In this population of men, Ca intake was a positive predictor, and blood pressure was a negative predictor of regional measures of bone mass. These findings support the concept that independent of age, BMI and Ca intake, elevated blood pressure varies indirectly with bone mass and density, known predictors of osteoporotic fractures. Future studies are needed to determine whether elevated blood pressure is causally related to the development of low bone mass, and what role dietary Ca plays in that pathway.

Keywords

Blood pressureCalcium intakeBone mass
Type
Research Article
Information
British Journal of Nutrition , Volume 81 , Issue 5 , May 1999 , pp. 383 - 388
Copyright
Copyright © The Nutrition Society 1999

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