Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-26T13:01:15.135Z Has data issue: false hasContentIssue false
  • English
  • Français

Bile acid conjugation and hepatic taurine concentration in rats fed on pectin

Published online by Cambridge University Press:  09 March 2007

T. Ide ,
M. Horii ,
K. Kawashima  and
T. Yamamoto
T. Ide
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
M. Horii
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
K. Kawashima
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
T. Yamamoto
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A relationship between bile acid conjugation and hepatic taurine concentration was investigated in rats fed on citrus pectin. When rats were fed on the diets containing varying amounts of pectin (10, 30, 60 and 100 g/kg dietary levels), biliary excretion of bile acids increased as the dietary levels of pectin increased. The increase was entirely due to the glycine-conjugated bile acids. The biliary excretion of taurine-conjugated bile acid was somewhat decreased as the dietary level of the fibre increased. Consequently, most of the bile acids were conjugated with glycine in rats fed on the diet containing 100 g pectin/kg. On the other hand, dietary cellulose (60 and 100 g/kg) did not affect the biliary bile acid excretions. The major proportion of bile acids in rats receiving a fibre-free diet and the diets containing cellulose were conjugated with taurine. Hepatic taurine concentrations decreased as the dietary levels of pectin, but not of cellulose, increased. Although dietary pectin (100 g/kg) also slightly decreased the taurine concentration in the kidney, those concentrations in other non-hepatic tissues examined (heart, brain and serum) were unaffected by the dietary fibre. Supplementation of the diet containing 100 g pectin/kg with methionine (10 g/kg) and taurine (10 and 50 g/kg) strikingly increased hepatic taurine concentrations. In this situation, the conjugation of bile acid with glycine was almost abolished and taurine conjugates became abundant in the bile of these animals. It is suggested that dietary pectin mediated an increase in the biliary bile acid excretion which may have depleted the hepatic pool of taurine available for bile acid conjugation and, thus, increased glycine conjugation of bile acids.

Keywords

Bile acid conjugationPectinTaurineRat
Type
Gastrointestinal Physiology, Digestion and Metabolism: Non-Ruminants
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 539 - 550
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

American Institute of Nutrition (1977). Report of the American Institute of Nutrition Ad Hoc Committee on standards for nutritional studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Armstrong, M.J. & Carey, M.C. (1987). Thermodynamic and molecular determinants of sterol solubilities in bile salt micells. Journal of Lipid Research 28, 1144–1155.CrossRefGoogle Scholar
Benevenga, N.J. (1974). Toxicities of methionine and other amino acids. Journal of Agricultural and Food Chemistry 22, 2–9.CrossRefGoogle ScholarPubMed
Bengmark, S., Ekdahl, P.-H. & Olsson, R. (1964). Effect of taurine and glycine treatment on the conjugation of bile acids in partially hepatectomized rats. Acta Chirurgica Scandinavica 128, 180–185.Google ScholarPubMed
Bergeret, B. & Chatagner, F. (1956). Influence d'unc carence en vitamin B6 sur la teneur en acides tauro-conjugués et glyco-conjugués de la bile du rat. Biochimica et Biophysica Acta 22, 273–277.CrossRefGoogle Scholar
Darling, P.B., Lepage, G. & Leroy, C. (1985). Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatric Research 19, 578–582.CrossRefGoogle ScholarPubMed
Duncan, D.B. (1957). Multiple range tests for correlated and heteroscedastic means. Biometrics 13, 164–176.CrossRefGoogle Scholar
Elliott, W.E. (1984). Metabolism of bile acid in liver and extrahepatic tissues. In Sterols and Bile Acids, pp. 303–329 [Danielsson, H. and Sjövall, J., editors]. Amsterdam: Elsevier Science Publishers B.V.Google Scholar
Folch, J., Lee, M. & Sloane-Stanley, G.H. (1957). A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Garbutt, J.T., Lack, L. & Tyor, M.P. (1971). Physiological basis of alterations in the relative conjugation of bile acids with glycine and taurine. American Journal of Clinical Nutrition 24, 218–228.CrossRefGoogle ScholarPubMed
Griffith, O.W. (1985). Glutathione and glutathione disulphide. In Methods of Enzymatic Analysis, 3rd English ed., pp. 521–529 [Bergmeyer, H.U., Bergmeyer, J. and Grabl, M., editors]. Deerfield Beach, FL: VCH Publishers.Google Scholar
Hardison, W.G.M. & Proffitt, J.H. (1977). Influence of hepatic taurine concentration on bile acid conjugation with taurine. American Journal of Physiology 232, E75–E79.Google ScholarPubMed
Haslewood, G.A.D. & Wooton, V. (1950). Comparative studies of ‘bile salts’. 1. Preliminary survey. Biochemical Journal 47, 584–597.CrossRefGoogle Scholar
Herrmann, R.G. (1959). Effect of taurine, glycine and β-sitosterol on serum and tissue cholesterol in the rat and rabbit. Circulation Research 7, 224–227.CrossRefGoogle Scholar
Higashi, T., Tateishi, N., Naruse, A. & Sakamoto, Y. (1977). A novel physiological role of liver glutathione as a reservoir of L-cysteine. Journal of Biochemistry 82, 117–124.CrossRefGoogle ScholarPubMed
Hosokawa, Y., Niizeki, S., Tojo, H., Sato, I. & Yamaguchi, K. (1988). Hepatic cysteine dioxygenase activity and sulfur amino acid metabolism in rats: possible indicators in the evaluation of protein quality. Journal of Nutrition 118, 456–461.CrossRefGoogle ScholarPubMed
Ide, T. & Horii, M. (1987). A simple method for the extraction and determination of non-conjugated and conjugated luminal bile acids in rats. Agricultural and Biological Chemistry 51, 3155–3157.Google Scholar
Ide, T. & Horii, M. (1989). Predominant conjugation with glycine of biliary and luminal bile acids in rats fed on pectin. British Journal of Nutrition 61, 545–557.CrossRefGoogle Scholar
Ide, T., Okamatsu, H. & Sugano, M. (1978). Regulation by dietary fats of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver. Journal of Nutrition 108, 601–612.CrossRefGoogle Scholar
Ide, T., Oku, H. & Sugano, M. (1982). Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver. Metabolism 31, 1065–1072.CrossRefGoogle ScholarPubMed
Jacobsen, J.G. & Smith, L.H. Jr (1968). Biochemistry and physiology of taurine and taurine derivatives. Physiological Reviews 48, 424–511.CrossRefGoogle ScholarPubMed
Killenberg, P.G. (1978). Measurement and subcellular distribution of choloyl-CoA synthetase and bile acid-CoA: amino acid N-acyltransferase activities in rat liver. Journal of Lipid Research 19, 24–31.CrossRefGoogle ScholarPubMed
Killenberg, P.G. & Jordan, J.T. (1978). Purification and characterization of bile acid-CoA: amino acid N− acyltransferase from rat liver. Journal of Biological Chemistry 235, 1005–1010.CrossRefGoogle Scholar
Kohashi, N., Yamaguchi, K., Hosokawa, Y., Kori, Y., Fujii, O. & Ueda, I. (1978). Dietary control of cysteine dioxygenase in rat liver. Journal of Biochemistry 84, 159–168.CrossRefGoogle ScholarPubMed
Kuriyama, K., Ban, Y. & Nakashima, T. (1979). Simultaneous determination of biliary bile acids in rat:Electron impact and ammonia chemical ionization mass spectrometric analyses of bile acids. Steroids 34, 717–728.Google ScholarPubMed
Larsen, B.R., Grosso, D.S. & Chang, S.Y. (1980). A rapid method for taurine quantitation using high performance liquid chromatography. Journal of Chromatographic Sciences 18, 233–236.CrossRefGoogle ScholarPubMed
Sjövall, J. (1959). Effects of dietary glycine and taurine on bile acid conjugation in man. Proceedings of the Society for Experimental Biology and Medicine 100, 676–678.CrossRefGoogle ScholarPubMed
Spaeth, D.G. & Schneider, D.L. (1974). Taurine synthesis. concentration, and bile salt conjugation in rat, guinea pig, and rabbit. Proceedings of the Society for Experimental Biology and Medicine 147, 855–858.CrossRefGoogle Scholar
Stephan, Z.F., Armstrong, M.J. & Hayes, K.C. (1981). Bile lipid alterations in taurine-depleted monkeys. American Journal of Clinical Nutrition 34, 204–210.CrossRefGoogle ScholarPubMed
Stephan, Z.F., Lindsey, S. & Hayes, K.C. (1987). Taurine enhances low density lipoprotein binding. Internalization and regulation by cultured Hep G2 cells. Journal of Biological Chemistry 262, 6069–6073.CrossRefGoogle Scholar
Sturman, J.A. (1973). Taurine pool sizes in the rat: Effects of vitamin B-6 deficiency and high taurine diet. Journal of Nutrition 103, 1566–1580.CrossRefGoogle ScholarPubMed
Sugano, M., Ide, T., Kohno, M., Cho, Y.-J. & Nagata, Y. (1983). Biliary and fecal steroid excretion in rats fed partially hydrogenated soybean oil. Lipids 18, 186–192.CrossRefGoogle ScholarPubMed
Tamesue, N., Inoue, T. & Juniper, K. (1973). Solubility of cholesterol in bile salt–lecithin model systems. Digestive Disease 18, 670–678.CrossRefGoogle ScholarPubMed
Tateishi, N., Higashi, T., Naruse, A., Nakashima, K., Shiozaki, H. & Sakamoto, Y. (1977). Rat liver glutathione: possible role as a reservoir of cysteine. Journal of Nutrition 107, 51–60.CrossRefGoogle ScholarPubMed
Thompson, G.N., Robb, T.A. & Davidson, G.P. (1987). Taurine supplementation, fat absorption, and growth in cystic fibrosis. Journal of Pediatrics 111, 501–506.CrossRefGoogle ScholarPubMed
Truswell, A.S., McVeigh, S., Mitchell, W.D. & Bronte-Stewart, B. (1965). Effect in man of feeding taurine on bile acid conjugation and serum cholesterol levels. Journal of Atherosclerosis Research 5, 526–533.CrossRefGoogle ScholarPubMed
Uchida, K., Nomura, Y., Kadowaki, M., Takeuchi, N. & Yamamura, Y. (1977). Effect of dietary cholesterol on cholesterol and bile acid metabolism in rats. Japanese Journal of Pharmacology 27, 193–204.CrossRefGoogle ScholarPubMed
Vessey, D.A. (1978). The biochemical basis for the conjugation of bile acid with either glycine or taurine. Biochemical Journal 174, 621–626.CrossRefGoogle ScholarPubMed
Vessey, D.A. (1979). The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N−acyltransferase activities from bovine liver. Journal of Biological Chemistry 254, 2059–2063.CrossRefGoogle ScholarPubMed
Weinstein, C.L., Haschemeyer, R.H. & Griffith, O.W. (1988). In vivo studies of cysteine metabolism: use of d− cysteinesulfinate, a novel cysteinesulfinate decarboxylase inhibitor to probe taurine and pyruvate synthesis. Journal of Biological Chemistry 263, 16568–16579.CrossRefGoogle ScholarPubMed
Yamanaka, Y., Tsuji, K. & Ichikawa, T. (1986). Stimulation of chenodeoxycholic acid excretion in hypercholesterolemic mice by dietary taurine. Journal of Nutritional Science and Vitaminology 32, 287–296.CrossRefGoogle ScholarPubMed
Yamanaka, Y., Tsuji, K., Ichikawa, T., Nakgawa, Y. & Kawamura, M. (1985). Effect of dietary taurine and taurocyamine on biliary glycine/taurine ratio and cholesterol and bile acid metabolisms. Sulfur Amino Acids 8, 209–214.Google Scholar