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Associations of plasma phospholipid fatty acids with plasma homocysteine in Chinese vegetarians

  • Tao Huang (a1) (a2), Xiaomei Yu (a3), Tianxing Shou (a1) (a2), Mark L. Wahlqvist (a1) (a2) (a4) and Duo Li (a1) (a2) (a5)...

Abstract

The association of plasma phospholipid (PL) fatty acid composition with plasma homocysteine (Hcy) in Chinese vegetarians is not understood. The main aim of the present study was to investigate the plasma PL fatty acid status, and its association with plasma Hcy in Chinese vegetarians and omnivores. A total of 103 male vegetarians and 128 male omnivores were recruited in Linyin Temple, Hangzhou. Plasma Hcy and PL fatty acid concentrations were determined by standard methods. Compared with omnivores, plasma PL n-3 PUFA (P< 0·001), 22 : 6n-3 (P< 0·001), 22 : 5n-6 (P= 0·021), 22 : 2n-6 (P< 0·001) and SFA (P= 0·017) were significantly lower, while plasma PL n-6 PUFA (P= 0·007) and total PUFA (P< 0·001) were significantly higher in vegetarians. The prevalence of hyperhomocysteinaemia (HHcy) in vegetarians (26·47 %) was significantly higher than that in omnivores (13·28 %). In vegetarians, plasma PL 22 : 6n-3 (r − 0·257, P= 0·046) was significantly negatively associated with plasma Hcy. In omnivores, plasma PL 18 : 1n-7 (r 0·237, P= 0·030) was significantly positively associated with plasma Hcy. Plasma PL 22 : 6n-3 (r − 0·217, P= 0·048) was negatively associated with plasma Hcy in omnivores. Plasma PL SFA were positively associated with the prevalence of HHcy. It would seem appropriate for vegetarians to increase their dietary n-3 PUFA and decrease dietary SFA, and thus reduce the risk of HHcy.

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Corresponding author

*Corresponding author: X. Yu, email yuxiaomei_1@hotmail.com; D. Li, fax +86 571 86971024, email duoli@zju.edu.cn

References

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1Messina, VK & Burke, KI (1997) Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc 97, 13171321.
2Davis, BC & Kris-Etherton, PM (2003) Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am J Clin Nutr 78, 640S646S.
3Janelle, KC & Barr, SI (1995) Nutrient intakes and eating behavior scores of vegetarian and nonvegetarian women. J Am Diet Assoc 95, 180186, 189 (quiz 187–188).
4Li, D (2011) Chemistry behind vegetarianism. J Agric Food Chem 59, 777784.
5Mann, NJ, Li, D, Sinclair, AJ, et al. (1999) The effect of diet on plasma homocysteine concentrations in healthy male subjects. Eur J Clin Nutr 53, 895899.
6Lee, HY, Woo, J, Chen, ZY, et al. (2000) Serum fatty acid, lipid profile and dietary intake of Hong Kong Chinese omnivores and vegetarians. Eur J Clin Nutr 54, 768773.
7Li, D, Yu, XM, Xie, HB, et al. (2007) Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients. Prostaglandins Leukot Essent Fatty Acids 76, 293297.
8Li, D, Mann, NJ & Sinclair, AJ (2006) A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids 41, 8589.
9Huang, T, Wahlqvist, ML & Li, D (2010) Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism. Nutrition 26, 112119.
10Huang, T, Tucker, K, Lee, Y, et al. (2012) MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations. Nutr Metab Cardiovasc Dis 22, 362368.
11Huang, T, Tucker, KL, Lee, YC, et al. (2011) Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in Puerto Rican adults. J Nutr 141, 654659.
12Sanders, TA (2009) DHA status of vegetarians. Prostaglandins Leukot Essent Fatty Acids 81, 137141.
13Li, D, Ball, M, Bartlett, M, et al. (1999) Lipoprotein(a), essential fatty acid status and lipoprotein lipids in female Australian vegetarians. Clin Sci (Lond) 97, 175181.
14Vizcaino, G, Diez-Ewald, M, Herrmann, FH, et al. (2005) [Homocysteinemia and its relationship with the methylentetrahydrofolate reductase polymorphism in various ethnic groups from western Venezuela]. Invest Clin 46, 347355.
15Cattaneo, M, Martinelli, I & Mannucci, PM (1996) Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 335, 974975.
16Li, D, Xu, T, Takase, H, et al. (2008) Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: a long-term randomized, double-blind controlled study. Clin Nutr 27, 203211.
17James, AT (1960) Qualitative and quantitative determination of the fatty acids by gas–liquid chromatography. Methods Biochem Anal 8, 159.
18Kris-Etherton, PM, Harris, WS & Appel, LJ (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.
19Leaf, A, Kang, JX, Xiao, YF, et al. (2003) Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107, 26462652.
20Harris, WS, Sands, SA, Windsor, SL, et al. (2004) Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation 110, 16451649.
21Harris, WS & Von Schacky, C (2004) The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 39, 212220.
22Huang, T, Bhulaidok, S, Cai, ZZ, et al. (2010) Plasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndrome. Mol Nutr Food Res 54, 16281635.
23Kornsteiner, M, Singer, I & Elmadfa, I (2008) Very low n-3 long-chain polyunsaturated fatty acid status in Austrian vegetarians and vegans. Ann Nutr Metab 52, 3747.
24Fokkema, MR, Brouwer, DA, Hasperhoven, MB, et al. (2000) Polyunsaturated fatty acid status of Dutch vegans and omnivores. Prostaglandins Leukot Essent Fatty Acids 63, 279285.
25Rosell, MS, Lloyd-Wright, Z, Appleby, PN, et al. (2005) Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. Am J Clin Nutr 82, 327334.
26Sanders, TA, Ellis, FR & Dickerson, JW (1978) Studies of vegans: the fatty acid composition of plasma choline phosphoglycerides, erythrocytes, adipose tissue, and breast milk, and some indicators of susceptibility to ischemic heart disease in vegans and omnivore controls. Am J Clin Nutr 31, 805813.
27Huang, T, Sinclair, AJ, Shen, LR, et al. (2009) Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats. J Food Lipids 16, 436451.
28Burdge, GC & Wootton, SA (2002) Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88, 411420.
29Hussein, N, Ah-Sing, E, Wilkinson, P, et al. (2005) Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. J Lipid Res 46, 269280.
30Simopoulos, AP (1999) Essential fatty acids in health and chronic disease. Am J Clin Nutr 70, 560S569S.
31Huang, T, Wahlqvist, ML & Li, D (2012) Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. Nutr J 11, 6.
32Zeman, M, Zak, A, Vecka, M, et al. (2006) N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J Nutr Biochem 17, 379384.
33Carrero, JJ, Lopez-Huertas, E, Salmeron, LM, et al. (2005) Daily supplementation with (n-3) PUFAs, oleic acid, folic acid, and vitamins B-6 and E increases pain-free walking distance and improves risk factors in men with peripheral vascular disease. J Nutr 135, 13931399.
34Beavers, KM, Beavers, DP, Bowden, RG, et al. (2008) Omega-3 fatty acid supplementation and total homocysteine levels in end-stage renal disease patients. Nephrology (Carlton) 13, 284288.
35Piolot, A, Blache, D, Boulet, L, et al. (2003) Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health. J Lab Clin Med 141, 4149.
36Carrero, JJ, Fonolla, J, Marti, JL, et al. (2007) Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. J Nutr 137, 384390.
37Pooya, S, Jalali, MD, Jazayery, AD, et al. (2010) The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis 20, 326331.
38Huang, T, Zheng, J, Chen, Y, et al. (2011) High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials. Nutrition 27, 863867.

Keywords

Associations of plasma phospholipid fatty acids with plasma homocysteine in Chinese vegetarians

  • Tao Huang (a1) (a2), Xiaomei Yu (a3), Tianxing Shou (a1) (a2), Mark L. Wahlqvist (a1) (a2) (a4) and Duo Li (a1) (a2) (a5)...

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