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The interaction effect of dietary selenium intake and the IL10 rs1800871 polymorphism on the risk of colorectal cancer: a case–control study in Korea

Published online by Cambridge University Press:  21 March 2024

Tao Thi Tran
Affiliation:
Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
Madhawa Gunathilake
Affiliation:
Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
Jeonghee Lee
Affiliation:
Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
Jae Hwan Oh
Affiliation:
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
Hee Jin Chang
Affiliation:
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
Dae Kyung Sohn
Affiliation:
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
Aesun Shin
Affiliation:
Department of Preventive Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea
Jeongseon Kim*
Affiliation:
Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
*
*Corresponding author: Jeongseon Kim, email jskim@ncc.re.kr

Abstract

The importance of Se in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of Se was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary Se. Our study aimed to explore whether Se potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effect on this association. We designed a case–control study with 1420 cases and 2840 controls. A semi-quantitative FFQ was used to obtain information on Se intake. We determined IL10 rs1800871 through genetic analysis. Different models were developed to explore Se intake related to CRC risk by calculating OR and 95 % CI using unconditional logistic regression. A reduced risk of CRC was found as Se intake increased, with an OR (95 % CI) of 0·44 (0·35, 0·55) (Pfor trend < 0·001). However, this association seems to be allele-specific and only present among risk variant allele carriers (GA/GG) with a significant interaction between dietary Se and IL10 rs1800871 (Pfor interaction = 0·043). We emphasised that a reduction in CRC risk is associated with appropriate Se intake. However, the IL10 rs1800871 polymorphism has an impact on this reduction, with a greater effect on variant allele carriers. These findings suggest the importance of considering an individual’s genetic characteristics when developing nutritional strategies for CRC prevention.

Type
Research Article
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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References

GBD 2019 Colorectal Cancer Collaborators (2022) Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Hepatol 7, 627647.CrossRefGoogle Scholar
Sung, H, Ferlay, J, Siegel, RL, et al. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71, 209249.CrossRefGoogle ScholarPubMed
Xi, Y & Xu, P (2021) Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol 14, 101174.CrossRefGoogle ScholarPubMed
Pourhoseingholi, MA (2014) Epidemiology and burden of colorectal cancer in Asia-Pacific region: what shall we do now? Transl Gastrointest Cancer 3, 169173.Google Scholar
Kang, MJ, Won, YJ, Lee, JJ, et al. (2022) Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2019. Cancer Res Treat 54, 330344.CrossRefGoogle ScholarPubMed
Myles, IA (2014) Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J 13, 61.CrossRefGoogle ScholarPubMed
Huang, Z, Rose, AH & Hoffmann, PR (2012) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 16, 705743.CrossRefGoogle ScholarPubMed
Duntas, LH (2009) Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res 41, 443447.CrossRefGoogle ScholarPubMed
Fagbohun, OF, Gillies, CR, Murphy, KPJ, et al. (2023) Role of antioxidant vitamins and other micronutrients on regulations of specific genes and signaling pathways in the prevention and treatment of cancer. Int J Mol Sci 24, 6092.CrossRefGoogle ScholarPubMed
Lener, MR, Gupta, S, Scott, RJ, et al. (2013) Can selenium levels act as a marker of colorectal cancer risk? BMC Cancer 13, 214.CrossRefGoogle ScholarPubMed
Combs, GF Jr (2015) Biomarkers of selenium status. Nutrients 7, 22092236.CrossRefGoogle ScholarPubMed
Luo, H, Fang, YJ, Zhang, X, et al. (2021) Association between dietary zinc and selenium intake, oxidative stress-related gene polymorphism, and colorectal cancer risk in Chinese population - a case-control study. Nutr Cancer 73, 16211630.CrossRefGoogle ScholarPubMed
Augustyniak, M & Galas, A (2022) Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland. BMC Nutr 8, 22.CrossRefGoogle ScholarPubMed
Cai, X, Wang, C, Yu, W, et al. (2016) Selenium exposure and cancer risk: an updated meta-analysis and meta-regression. Sci Rep 6, 19213.CrossRefGoogle ScholarPubMed
Vinceti, M, Filippini, T, Del Giovane, C, et al. (2018) Selenium for preventing cancer. Cochrane Database Syst Rev 2018 issue 1, CD005195.CrossRefGoogle Scholar
Zhao, H, Wu, L, Yan, G, et al. (2021) Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther 6, 263.CrossRefGoogle ScholarPubMed
Abtahi, S, Davani, F, Mojtahedi, Z, et al. (2017) Dual association of serum interleukin-10 levels with colorectal cancer. J Cancer Res Ther 13, 252256.Google ScholarPubMed
Kawamura, K, Bahar, R, Natsume, W, et al. (2002) Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors. Cancer Gene Ther 9, 109115.CrossRefGoogle ScholarPubMed
Banday, MZ, Sameer, AS, Chowdri, N, et al. (2017) Interleukin-10 -592C/A, but not -1082A/G promoter single nucleotide polymorphism, is associated with a decreased risk of colorectal cancer in an ethnic Kashmiri population: a case-control study. Eur J Cancer Prev 26, 476490.CrossRefGoogle ScholarPubMed
Stanilov, N, Miteva, L, Deliysky, T, et al. (2010) Advanced colorectal cancer is associated with enhanced Interleukin-23 and Interleukin-10 serum level. Lab Med 41, 159163.CrossRefGoogle Scholar
Li, B, Wang, F, Ma, C, et al. (2019) Predictive value of IL-18 and IL-10 in the prognosis of patients with colorectal cancer. Oncol Lett 18, 713719.Google ScholarPubMed
Moghimi, M, Ahrar, H, Karimi-Zarchi, M, et al. (2018) Association of IL-10 rs1800871 and rs1800872 Polymorphisms with breast cancer risk: a systematic review and meta-analysis. Asian Pac J Cancer Prev 19, 33533359.CrossRefGoogle Scholar
Tsilidis, KK, Helzlsouer, KJ, Smith, MW, et al. (2009) Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control 20, 17391751.CrossRefGoogle ScholarPubMed
Kim, J, Cho, YA, Choi, WJ, et al. (2014) Gene–diet interactions in gastric cancer risk: a systematic review. World J Gastroenterol 20, 96009610.CrossRefGoogle ScholarPubMed
Zhang, X, Zhang, L, Xia, K, et al. (2022) Effects of dietary selenium on immune function of spleen in mice. J Funct Foods 89, 104914.CrossRefGoogle Scholar
Zhou, Y, Yuan, S, Xiao, F, et al. (2023) Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity. Chem Sci 14, 1057010579.CrossRefGoogle ScholarPubMed
Rafferty, TS, Walker, C, Hunter, JA, et al. (2002) Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds. Br J Dermatol 146, 485489.CrossRefGoogle ScholarPubMed
Ahn, Y, Kwon, E, Shim, JE, et al. (2007) Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study. Eur J Clin Nutr 61, 14351441.CrossRefGoogle ScholarPubMed
Lu, Y, Kweon, SS, Cai, Q, et al. (2020) Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians. Cancer Epidemiol Biomarkers Prev 29, 477486.CrossRefGoogle ScholarPubMed
Willett, W & Stampfer, MJ (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124, 1727.CrossRefGoogle ScholarPubMed
Hughes, DJ, Fedirko, V, Jenab, M, et al. (2015) Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer 136, 11491161.CrossRefGoogle ScholarPubMed
Björnstedt, M & Fernandes, AP (2010) Selenium in the prevention of human cancers. EPMA J 1, 389395.CrossRefGoogle ScholarPubMed
Rayman, MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64, 527542 CrossRefGoogle ScholarPubMed
Mirjalili, SR, Moghimi, M, Aghili, K, et al. (2018) Association of promoter region polymorphisms of interleukin-10 gene with susceptibility to colorectal cancer: a systematic review and meta-analysis. Arq Gastroenterol 55, 306313.CrossRefGoogle ScholarPubMed
Cacev, T, Radosević, S, Krizanac, S, et al. (2008) Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinog 29, 15721580.CrossRefGoogle ScholarPubMed
Gunter, MJ, Canzian, F, Landi, S, et al. (2006) Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev 15, 11261131.CrossRefGoogle ScholarPubMed
Li, S, Zhao, Q, Zhang, K, et al. (2020) Se deficiency induces renal pathological changes by regulating selenoprotein expression, disrupting redox balance, and activating inflammation. Metallomics 12, 15761584.CrossRefGoogle ScholarPubMed
Zhang, YH, Xing, YQ, Chen, Z, et al. (2019) Association between interleukin-10 genetic polymorphisms and risk of primary open angle glaucoma in a Chinese Han population: a case-control study. Int J Ophthalmol 12, 16051611.CrossRefGoogle Scholar
Yu, Y, Zheng, S, Zhang, S, et al. (2014) Polymorphisms of inflammation-related genes and colorectal cancer risk: a population-based case-control study in China. Int J Immunogenet 41, 289297.CrossRefGoogle Scholar
Kim, SE, Paik, HY, Yoon, H, et al. (2015) Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 21, 51675175.CrossRefGoogle ScholarPubMed
Park, Y, Lee, J, Oh, JH, et al. (2016) Dietary patterns and colorectal cancer risk in a Korean population: a case-control study. Medicine (Baltimore) 95, e3759.CrossRefGoogle Scholar
Wei, EK, Giovannucci, E, Wu, K, et al. (2004) Comparison of risk factors for colon and rectal cancer. Int J Cancer 108, 433442.CrossRefGoogle ScholarPubMed
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