Objective: This exploratory study applied a biopsychosocial perspective to investigate cognitive and psychosocial factors related to emotional adjustment and QoL after brain tumour. Methods: Participants included 30 adults with a brain tumour (60% benign and 40% malignant) who were aged 28 to 71 years (M = 51.5, SD = 12.3) and on average 5.4 years post-diagnosis (SD = 5.6 years). Participants completed a brief battery of cognitive tests and self-report measures of emotional status (Depression, Anxiety Stress Scale), subjective impairment (Patient Competency Rating Scale), coping (COPE), social support (Brief Social Support Questionnaire), and QoL (Functional Assessment of Cancer Therapy — Brain Tumour [FACT-Br]). Results: QoL was significantly associated with global cognitive ability (r = .49, p < .01), subjective impairment (r = .66, p < .01), and satisfaction with support (r = .50, p < .05). Level of depressive symptoms was significantly correlated with premorbid IQ (r = -.49, p < .01), use of planning to cope (r = -.48, p < .01), and satisfaction with support (r = -.47, p < .01). Conclusions: Overall, these exploratory findings indicate that emotional adjustment and QoL after brain tumour is related to a slightly different pattern of neuropsychological, psychological (self-perceptions and coping) and social factors. The clinical implications for interventions with individuals with brain tumour are discussed.