A within-participant multiple baseline experiment evaluated effects of in-home neurobehavioural interventions on functional behaviour of 3 persons with brain injury, and their spouses' burden of care. The 6-week individualised interventions included in-home and telephone consultations. Measures consisted of functional behaviour of the injured persons, spouses' burden of care using the QRS-SF at preand postintervention and at 1 month follow-up, and social validity. Results show interventions were efficacious in improving functional behaviour, but effects on burden of care and social validity were mixed. One caregiver who presented with high levels of burden at preintervention reported reduced burden, while the other 2 who presented with low to moderate burden reported no changes.