An online survey of adult women living in Australia with an acquired or congenital disability was conducted to explore the needs and challenges experienced by this population. Data for 116 respondents with a primary mobility (n = 92), sensory-related (n = 12), psychiatric (n = 6), or neurocognitive impairment (n = 6) were collected. Word clouds and content analysis were utilised to examine the data. Barriers to achieving vocational, health and relationship goals were identified, including systemic (e.g. financial resources, accessibility issues, societal attitudes), physical (e.g. medical sequalae), and psychological (e.g. self-concept, assertiveness) issues. Strategies to overcome these barriers included increased availability of peer support networks and opportunities for personal development. It follows that disability services require a multi-faceted approach, with a focus on biopsychosocial factors that include, but are not limited to, mobility, self-care and communication needs.