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Prospection of genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line

Published online by Cambridge University Press:  17 July 2014

C. T. Meira ,
R. A. Curi ,
M. M. Farah ,
H. N. de Oliveira ,
N. A. R. Béltran ,
J. A. II V. Silva  and
M. D. S. da Mota
C. T. Meira*
Affiliation:
Department of Animal Science, College of Agriculture and Veterinary Science, São Paulo State University (UNESP), Access Route Paulo Donato Castellane, 14884-900 Jaboticabal, São Paulo, Brazil
R. A. Curi
Affiliation:
Department of Animal Breeding and Nutrition, College of Veterinary and Animal Science, São Paulo State University (UNESP), Rubião Junior District, 18618-970 Botucatu, São Paulo, Brazil
M. M. Farah
Affiliation:
Department of Animal Science, College of Agriculture and Veterinary Science, São Paulo State University (UNESP), Access Route Paulo Donato Castellane, 14884-900 Jaboticabal, São Paulo, Brazil
H. N. de Oliveira
Affiliation:
Department of Animal Science, College of Agriculture and Veterinary Science, São Paulo State University (UNESP), Access Route Paulo Donato Castellane, 14884-900 Jaboticabal, São Paulo, Brazil
N. A. R. Béltran
Affiliation:
Department of Animal Science, College of Agriculture and Veterinary Science, São Paulo State University (UNESP), Access Route Paulo Donato Castellane, 14884-900 Jaboticabal, São Paulo, Brazil
J. A. II V. Silva
Affiliation:
Department of Animal Breeding and Nutrition, College of Veterinary and Animal Science, São Paulo State University (UNESP), Rubião Junior District, 18618-970 Botucatu, São Paulo, Brazil
M. D. S. da Mota
Affiliation:
Department of Animal Breeding and Nutrition, College of Veterinary and Animal Science, São Paulo State University (UNESP), Rubião Junior District, 18618-970 Botucatu, São Paulo, Brazil
*
†E-mail: camilatangari@zootecnista.com.br
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Abstract

Selection of Quarter Horses for different purposes has led to the formation of lines, including racing and cutting horses. The objective of this study was to identify genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line applying relative extended haplotype homozygosity (REHH) analysis, an extension of extended haplotype homozygosity (EHH) analysis, and the fixation index (FST) statistic. A total of 188 horses of both sexes, born between 1985 and 2009 and registered at the Brazilian Association of Quarter Horse Breeders, including 120 of the racing line and 68 of the cutting line, were genotyped using single nucleotide polymorphism arrays. On the basis of 27 genomic regions identified as selection signatures by REHH and FST statistics, functional annotations of genes were made in order to identify those that could have been important during formation of the racing line and that could be used subsequently for the development of selection tools. Genes involved in muscle growth (n=8), skeletal growth (n=10), muscle energy metabolism (n=15), cardiovascular system (n=14) and nervous system (n=23) were identified, including the FKTN, INSR, GYS1, CLCN1, MYLK, SYK, ANG, CNTFR and HTR2B.

Keywords

equinefixation indexextended haplotype homozygosityselection signatureSNP array
Type
Research Article
Information
animal , Volume 8 , Issue 11 , November 2014 , pp. 1754 - 1764
Copyright
© The Animal Consortium 2014 

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