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Analyses of reaction norms reveal new chromosome regions associated with tick resistance in cattle

Published online by Cambridge University Press:  13 July 2017

R. R. Mota ,
F. F. Silva ,
P. S. Lopes ,
R. J. Tempelman ,
B. P. Sollero ,
I. Aguilar  and
F. F. Cardoso
R. R. Mota*
Affiliation:
Gembloux Agro-Bio Tech Faculty, TERRA Teaching and Research Centre, University of Liège, B-5030 Gembloux, Belgium
F. F. Silva
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-900 Viçosa, Minas Gerais, Brazil
P. S. Lopes
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-900 Viçosa, Minas Gerais, Brazil
R. J. Tempelman
Affiliation:
Department of Animal Science, Michigan State University, 48824 East Lansing, MI, USA
B. P. Sollero
Affiliation:
Embrapa Pecuária Sul, 96401-970 Bagé, Rio Grande do Sul, Brazil
I. Aguilar
Affiliation:
Instituto Nacional de Investigación Agropecuaria – INIA Las Brujas-Canelones, Ruta 48 km 10, Rincon del Colorado, Departamento de Canelones, Uruguay
F. F. Cardoso
Affiliation:
Embrapa Pecuária Sul, 96401-970 Bagé, Rio Grande do Sul, Brazil Programa de Pós-graduação em Zootecnia, Universidade Federal de Pelotas, 96010-610 Pelotas, Rio Grande do Sul, Brazil
*
†E-mail: rrmota@ulg.ac.be
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Abstract

Despite single nucleotide polymorphism (SNP) availability and frequent cost reduction has allowed genome-wide association studies even in complex traits as tick resistance, the use of this information source in SNP by environment interaction context is unknown for many economically important traits in cattle. We aimed at identifying putative genomic regions explaining differences in tick resistance in Hereford and Braford cattle under SNP by environment point of view as well as to identify candidate genes derived from outliers/significant markers. The environment was defined as contemporary group means of tick counts, since they seemed to be the most appropriate entities to describe the environmental gradient in beef cattle. A total of 4363 animals having tick counts (n=10 673) originated from 197 sires and 3966 dams were used. Genotypes were acquired on 3591 of these cattle. From top 1% SNPs (410) having the greatest effects in each environment, 75 were consistently relevant in all environments, which indicated SNP by environment interaction. The outliers/significant SNPs were mapped on chromosomes 1, 2, 5, 6, 7, 9, 11, 13, 14, 15, 16, 18, 21, 23, 24, 26 and 28, and potential candidate genes were detected across environments. The presence of SNP by environment interaction for tick resistance indicates that genetic expression of resistance depends upon tick burden. Markers with major portion of genetic variance explained across environments appeared to be close to genes with different direct or indirect functions related to immune system, inflammatory process and mechanisms of tissue destruction/repair, such as energy metabolism and cell differentiation.

Keywords

beef cattlecandidate genesenvironmental gradientgene functionsingle-step
Type
Research Article
Information
animal , Volume 12 , Issue 2 , February 2018 , pp. 205 - 214
Copyright
© The Animal Consortium 2017 

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