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Effects of Gene-Environment Interactions on Cardiovascular Risk Factors in Chinese Adolescent Twins

Published online by Cambridge University Press:  01 August 2014

C.J. Chen ,
B.H. Cohen ,
E.L. Diamond ,
T.M. Lin  and
J.S. Chen
C.J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan
B.H. Cohen
Affiliation:
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
E.L. Diamond
Affiliation:
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
T.M. Lin
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan
J.S. Chen
Affiliation:
Department of Clinical Pathology, National Taiwan University Hospital, Taipei, Taiwan
*
Institute of Public Health National Taiwan University College of Medicine, Taipei, Taiwan 100

Abstract

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A population-based sample of 73 male and 77 female monozygotic (MZ), and 41 male and 33 female dizygotic (DZ) Chinese adolescent twin pairs were studied to assess effects of gene-environment interactions of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels. Intrapair concordance in BP levels was found to be significantly associated with the interaction of zygosity and salty foods preference and also with that of zygosity and vegetable preference. A consistently positive and statistically significant association was observed between the intrapair difference in serum cholesterol and the interaction of zygosity and animal organ preference; while intrapair concordance in serum cholesterol was associated with the interaction of zygosity and milk consumption. Intrapair difference in serum triglycerides was associated with the interaction of zygosity and fish preference, and a significant association was also found between the intrapair concordance in serum triglycerides and the interaction of zygosity and sweets preference. These observations suggest that the impact of these environmental agents may be influenced by the genotype.

Keywords

Blood pressureCholesterolTriglyceridesDietGene-environment interactionTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 3 , July 1984 , pp. 383 - 396
Copyright
Copyright © The International Society for Twin Studies 1984

References

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