The creative sector has emerged as a critical driver of digital trade and generates significant opportunities for economic diversification and competitiveness in developed and developing economies. The expansion of the digital creative economy creates not just new and alternative business models, it also generates new markets, which make creative industries a critical resource for economic development. This chapter assesses the challenges and opportunities for creative industries in developing countries, especially as it relates to making the transition to a digital creative economy and to the adoption of blockchain technologies which have the potential to address structural challenges such as big data management, financial inclusion and integration into global value chains.