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  • Print publication year: 2014
  • Online publication date: June 2014

Chapter 44 - Neurorehabilitation in epilepsy

from Section 7 - Disease-specific neurorehabilitation systems

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1. Morrell F, Whisler WW, Smith MC, et al. Landau-Kleffner Syndrome: a treatment with subpial transcortical transections. Brain 1995; 118: 1529–46.
2. Vickrey BG, Hays RD, Graber J, et al. A health related quality of life instrument for patients evaluated for epilepsy surgery. Med Care 1992; 30: 299–319.
3. Stavem K, Bjornaes H, Lossius MI. Reliability and validity of a Norwegian version of the quality of life in epilepsy inventory (QOLIE-89). Epilepsia 2000; 41: 91–7.
4. Vickrey BG, Hays RD, Rausch R, et al. Outcomes in 248 patients who had diagnostic evaluations for epilepsy surgery. Lancet 1995; 346: 1445–9.
5. Meador KJ. (1993). Research use of the new quality-of-life in epilepsy inventory. Epilepsia 1993; 34: S34–8.
6. Sillanpaa M, Jalava M, Kaleva D, et al. Long-term prognosis of seizures with onset in childhood. N Engl J Med 1998; 338: 1715–22.
7. Camfield C, Camfield P. Social outcome of children with epilepsy and normal intelligence: long-term follow-up of a population based cohort. In Tuxhorn I, Holthausen H, Boenigk H, eds. Pediatric Epilepsy Syndromes and their Surgical Treatment. John Libbey: London, 1997; 44–7.
8. Sillanpaa M. Social adjustment and functioning of chronically ill and impaired children and adolescents. Acta Paediatr Scand 1987; 340: 1–70.
9. Schachter SC, Shafer PO, Murphy W. The personal impact of seizures: correlations with seizure frequency, employment, cost of medical care, and satisfaction with physician care. J Epilepsy 1993; 6: 224–7.
10. Austin JK, Risinger MW, Beckett LA. Correlates of behavior problems in children with epilepsy. Epilepsia 1992; 33: 1115–22.
11. Hoare P, Kerley S. Psychosocial adjustment of children with chronic epilepsy and their families. Dev Med Child Neurol 1991; 33: 201–15.
12. Austin JK, Smith MS, Risinger MW, et al. Childhood epilepsy and asthma: comparison of quality of life. Epilepsia 1994; 35: 608–15.
13. Margalit M, Heiman T. Anxiety and self-dissatisfaction in epileptic children. Int J Soc Psychiatr 1983; 29: 220–4.
14. Matthews WS, Barabas G, Ferrari M. Emotional concomitants of childhood epilepsy. Epilepsia 1982; 23: 671–81.
15. Tellez-Zenteno JF, Patten SB, Jetté N, et al. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 2007; 48: 2336–44.
16. Perrine K, Hermann BP, Meador KJ, et al. The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol 1995; 52: 997–1003.
17. Lehrner J, Kalchmayr R, Serles R, et al. Health-related quality of life (HRQOL), activity of daily living (ADL) and depressive mood disorder in temporal lobe epilepsy patients. Seizure 1999; 8: 88–92.
18. Gilliam F, Kuzniecky R, Meador K, et al. Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsy. Neurology 1999; 53: 687–94.
19. Gilliam F. Optimizing health outcomes in active epilepsy. Neurology 2002; 58: S9–19.
20. Kanner AM, Barry JJ, Gilliam F, et al. Anxiety disorders, sub-syndromic depressive episodes and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy? Epilepsia 2010; 51: 1152–8.
21. Devinsky O, Westbrook L, Cramer J, et al. Risk factors for poor health-related quality of life in adolescents with epilepsy. Epilepsia 1990; 40: 1715–20.
22. Dodrill CB. Neuropsychological effects of seizures. Epilepsy Behav 2004; 5:S21–4.
23. Bolton PF, Park RJ, Higgins JN, et al. Neuroepileptic determinants of autism spectrum disorders in tuberous sclerosis complex. Brain 2002; 125: 1247–55.
24. Dodrill CB, Wilensky AJ. Intellectual impairment as an outcome of status epilepticus. Neurology 1990; 40: 23–7.
25. Dodrill CB. Progressive cognitive decline in adolescents and adults with epilepsy. Prog Brain Res 2002; 135: 399–407.
26. Aarts JHP, Binnie CD, Smit AM, et al. Selective cognitive impairment during focal and generalized epileptiform EEG activity. Brain 1984; 107: 293–308.
27. Binnie C.D. Seizures, EEG discharges and cognition. In Trimble MR, Reynolds EH, eds. Epilepsy, Behavior and Cognitive Function. New York, NY: Wylie, 1987; 45–51.
28. Kateleijn-Nolst Trenite DGA, Smit AM, Velis DN, et al. On-line detection of transient neuropsychological disturbances during EEG discharges in children with epilepsy. Dev Med Child Neurol 1990; 32: 46–50.
29. Meador KJ, Loring DW, Allen ME, et al. Comparative of carbamazepine and phenytoin in healthy adults. Neurology 1991; 41: 1537–40.
30. Meador KJ, Loring DW, Abney OL, et al. Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia 1993; 34: 153–7.
31. Meador KJ, Loring DW, Moore EE, et al. Comparative cognitive effects of carbamazepine and phenytoin, and valproate in healthy adults. Neurology 1995; 45: 1494–9.
32. Vining EPG, Mellitis ED, Dorsen MM, et al. Psychologic and behavioral effects of antiepileptic drugs in children: a double-blind comparison between phenobarbital and valproic acid. Pediatrics 1987; 80: 165–74.
33. Martin R, Kuzniecky R, Ho S, et al. Cognitive effects of topiramate, gabapentin and lamotrigine in healthy young adults. Neurology 1990; 52: 321–7.
34. Kanner AM, Barry JJ, Gilliam F, et al. Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events? Epilepsia 2012; 53: 1104–8.
35. Lewis A. Melancholia: a historical review. J Mental Sci 1934; 80: 1–42.
36. Jacoby A, Baker GA, Steen N, et al, The clinical course of epilepsy and its psychosocial correlates: findings from a U.K. Community study. Epilepsia 1996; 37: 148–61.
37. O'Donoghue MF, Goodridge DM, Redhead K, et al. Assessing the psychosocial consequences of epilepsy: a community-based study. Br J Gen Pract 1999; 49: 211–14.
38. Edeh J, Toone B. Relationship between interictal psychopathology and the type of epilepsy. Results of a survey in general practice. Br J Psychiatry 1987; 151: 95–101.
39. Rutter M, Graham P, Yule WA. Neuropsychiatric Study in Childhood. Philadelphia, PA: J. B. Lippincott Co, 1970.
40. McDermott S, Mani S, Krishnaswami S. A population-based analysis of specific behavior problems associated with childhood seizures. J Epilepsy 1995; 8: 110–18.
41. Carlton-Ford S, Miller R, Brown M, et al. Epilepsy and children's social and psychological adjustment. J Health Soc Behav 1995; 36: 285–301.
42. Hempel AM, Frost MD, Ritter FJ, et al. Factors influencing the incidence of ADHD in pediatric epilepsy patients. Epilepsia 1995; 36: 122.
43. Semrud-Clikeman M, Wical B. Components of attention in children with complex partial seizures with and without ADHD. Epilepsia 1999; 40: 211–15.
44. Dunn D. Attention Deficit Disorder in Epilepsy In A Ettinger A, Kanner AM, eds. Psychiatric Issues in Epilepsy: A Practical Guide to Diagnosis and Treatment. Philadelphia, PA: Lippincott Williams and Wilkins, 2001.
45. Adelow C, Anderson T, Ahlbom A, et al. Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy. Neurology 2012; 78: 396–401.
46. Hesdorffer DC, Ishihara L, Mynepalli L, et al. Epilepsy, suicidality and psychiatric disorders: a bidirectional association. Ann Neurol 2012; 72: 184–91.
47. McAfee AT, Chilcott KE, Johannes CB, et al. The incidence of first unprovoked seizure in pediatric patients with and without psychiatric diagnoses. Epilepsia 2007; 48: 1075–82.
48. Hesdorffer DC, Ludvigsson P, Olafsson E, et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry 2004; 61: 731–6.
49. Jones JE, Watson R, Sheth J, et al. Psychiatric comorbidity in patients with epilepsy. Dev Med Child Neurol 2007; 49: 493–7.
50. Berg AT, Smith SN, Frobish D, et al. Special education needs of children with newly diagnosed epilepsy. Dev Med Child Neurol 2005; 47: 749–53.
51. Forsgren L, Nystrom L. An incident case referent study of epileptic seizures in adults. Epilepsy Res 1990; 6: 66–81.
52. Hesdorffer DC, Hauser WA, Annegers JF, et al. Major depression is a risk factor for seizures in older adults. Ann Neurol 2000; 47: 246–9.
53. Hesdorffer DC, Hauser WA, Ludvigsson P, et al. Depression and attempted suicide as risk factors for incident unprovoked seizures and epilepsy. Ann Neurol 2006; 59: 35–41.
54. Alper KR, Schwartz KA, Kolts RL, et al. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry 2007; 62: 345–54.
55. Blanchet P, Frommer GP. Mood change preceding epileptic seizures. J Nerv Ment Dis 1986; 174: 471–6.
56. Williams D. The structure of emotions reflected in epileptic experiences. Brain 1956; 79: 29–67.
57. Vazquez B, Devinsky O. Epilepsy and anxiety. Epilepsy Behav 2003; 4: S20–5.
58. Trimble MR. Psychosis of Epilepsy. New York, NY: Raven Press, 1991.
59. Devinsky O, Kelly K, Porter RG, et al. Clinical and electroencephalographic features of simple partial seizures. Neurology 1988; 43: 1347–52.
60. Kanner AM, Soto A, Gross-Kanner HR. Prevalence and clinical characteristics of postictal psychiatric symptoms. Neurology 2004; 62: 708–13.
61. Onuma T, Adachi N, Ishida S, et al. Prevalence and annual incidence of psychosis in patients with epilepsy. Psychiatry Clin Neuros 1995; 49: S267–8.
62. Kanner AM, Stagno S, Kotagal P, et al. Postictal psychiatric events during prolonged video-electroencephalographic monitoring studies. Arch Neurol 1996; 53: 258–63.
63. Devinsky O, Abrahmson H, Alper K. et al. Postictal psychosis: a case control study of 20 patients and 150 controls. Epilepsy Res 1995; 20: 247–53.
64. Kanemoto K, Kawasaki J, Kawai J. Postictal psychosis: a comparison with acute interictal and chronic psychoses. Epilepsia 1996; 37: 551–6.
65. Logsdail SJ, Toone BK. Postictal psychosis. A clinical and phenomenological description. Br J Psychiatry 1988; 152: 246–52.
66. So NK, Savard G, Andermann F, et al. Acute postictal psychosis: a stereo-EEG study. Epilepsia 1990; 31: 188–93.
67. Kanner AM, Ostrovskaya A. Long-term significance of postictal psychotic episodes II. Are they predictive of interictal psychotic episodes? Epilepsy Behav 2008; 12: 154–6.
68. Anthony JC, Eaton WW, Henderson AS. Looking in the future of psychiatric etiology. Epidemiol Rev 1995; 17: 240–2.
69. Costello EJ. Developments in child psychiatric epidemiology. J Am Acad Child Adolesc Psychiatry 1989; 28: 836–41.
70. Kanner AM, Palac S. Depression in epilepsy: a common but often unrecognized comorbid malady. Epilepsy Behav 2000; 1: 37–51.
71. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1995; 51: 8–19.
72. Mendez MF, Cummings J, Benson D, et al. Depression in epilepsy. Significance and phenomenology. Arch Neurol 1986; 43: 766–70.
73. Wiegartz P, Siedenberg M, Woodard A, et al. Co-morbid psychiatric disorders in chronic epilepsy: recognition and etiology of depression. Neurology 1999; 53: 2–8.
74. Kanner AM, Kozak AM, Frey M. The use of sertraline in patients with epilepsy: is it safe? Epilepsy Behav 2000; 1: 100–5.
75. Kraepelin E. Psychiatrie. Leipzig: Johann Ambrosius Barth, 1923.
76. Bleuler E. Lehrbuch der Psychiatrie. 8th edn. Berlin: Springer, 1949.
77. Gastaut H, Morin G, Lesèvre N. Étude du comportement des épileptiques psychomoteurs dans l'intervalle de leurs crises: les troubles de l'activité globale et de la sociabilité. Ann Med Psychol 1955; 113: 1–27.
78. Blumer D, Altshuler LL. Affective disorders. In Engel J, Pedley TA, eds. Epilepsy: A Comprehensive Textbook. Philadelphia, PA: Lippincott–Raven, 1998; 2083–99.
79. Mula M, Jauch R, Cavanna A, et al. Clinical and psychopathological definition of the interictal dysphoric disorder of epilepsy. Epilepsia 2008; 49: 650–6.
80. Sherman EM, Slick DJ, Connolly MB, et al. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia 2007; 48: 1083–91.
81. Barkley RA. Attention-Deficit/Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. 3rd edn. New York, NY: Guilford, 2006.
82. Jacoby A. Felt versus enacted stigma: a concept revisited. Soc Sci Med 1994; 38: 269–74.
83. Scambler G, Hopkins A. Being epileptic: coming to terms with stigma. Sociol Health Ill 1986; 8: 26–43.
84. Gil-Nagel A, Garcia Damberre P. The social impact of epilepsy: keeping our patients in the closet. In Ettinger A, Kanner AM, eds. Psychiatric Issues in Epilepsy: A Practical Guide to Diagnosis and Treatment. Philadelphia, PA: Lippincott Williams and Wilkins, 2001; 289–96.
85. Edwards VE. Social problems confronting a person with epilepsy in modern society. Proc Aust Assoc Neurol 1974; 11: 239–43.
86. Baker GA, Brooks J, Buck D, et al. The stigma of epilepsy: a European perspective. Epilepsia 2000; 41: 98–104.
87. Trostle JA. Social aspects: stigma, beliefs and measurement. In Engel J, Pedley TA, eds. Epilepsy: A Comprehensive Textbook. Philadelphia, PA: Lippincott–Raven, 1997; 2183–9.
88. Gilliam F, Kuzniecky R, Faught E. Patient-validated content of epilepsy-specific quality of life measurement. Epilepsia 1997; 38: 233–6.
89. Fisher RS, Bortz JJ, Blum DE, et al. A pilot study of donepezil for memory problems in epilepsy. Epilepsy Behav 2001; 2: 330–4.
90. Chelune GL, Najm RI, Luders H, et al. Individual change after epilepsy surgery: practice effects and base rate information. Neuropsychology 1993; 1: 41–52.
91. Gilliam FG, Black KJ, Carter J, et al. Depression and Health Outcomes in Epilepsy: A Randomized Trial. Proc 61st Ann Meet Am Acad Neurol Seattle, WA, 2009.
92. Wiebe S, Blume WT, Girvin JP, et al. Effectiveness and efficiency of surgery for temporal-lobe epilepsy. N Engl J Med 2001; 345: 311–18.
93. Engel J, Wiebe J, French J, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy. Neurology 2003; 60: 538–47.
94. Burg AT. Understanding the delay before the epilepsy surgery: Who develops intractable epilepsy and when? CNS Spectr 2004; 2: 136–44.
95. Kanner AM, Byrne R, Chicharro A, et al. A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy. Neurology 2009; 72: 793–9.
96. Engel J, Van Nes P, Rasmussen TB, et al. Outcome with respect to epileptic seizures. In Engel J, ed. 2nd ed. New York, NY: Raven Press, 1993; 609–621.
97. Anhoury S, Brown RJ, Krishnamoorthy ES, et al. Psychiatric outcome after temporal lobectomy: a predictive study. Epilepsia 2000; 41: 1608–15.
98. Martin RC, Sawrie SM, Roth DL, et al. Individual memory change after anterior temporal lobectomy: a base rate analysis using registration based outcome methodology. Epilepsia 1998; 39: 1075–82.
99. Novelly RA, Augustine EA, Mattson RH, et al. Selective memory improvement and impairment in temporal lobectomy in epilepsy. Ann Neurol 1984; 15: 64–7.
100. Ojieman G, Dodrill CB. Verbal memory deficits after left temporal lobectomy for epilepsy. J Neurosurg 1985; 62: 101–7.
101. Rausch R, Crandal PH. Psychological status related to surgical control of temporal lobe seizures. Epilepsia 1982; 23: 191–202.
102. Saykin AJ, Gur RC, Sussman NM, et al. Memory before and after temporal lobectomy: effects of laterality and age of onset. Brain Cogn 1989; 9: 191–200.
103. Herman BP, Wyler AR, Somes G, et al. Declarative memory following anterior temporal lobectomy in humans. Behav Neurosci 1984; 108: 3–10.
104. Herman BP, Wyler AR, Somes G. Memory loss following left anterior temporal lobectomy is associated with hippocampal pathology and not extend of hippocampal resection. J Clin Exp Neurophysiol 1993; 6: 350.
105. Kneebone AC, Chelune GJ, Dinner D, et al. Use of intracarotid amobarbital procedure to predict material specific memory change following anterior temporal lobectomy. Epilepsia 1995; 36: 857–65.
106. Sass KJ, Westerveld M, Bachanan CP, et al. Degree of hippocampal neuron loss determines severity of verbal memory decrease after anteromesiotemporal lobectomy. Epilepsia 1994; 35: 1179–86.
107. Seidenberg M, Hermann B, Wyler AR, et al. Neuropsychological outcome following anterior temporal lobectomy in patients with and without the syndrome of mesial temporal epilepsy. Neuropsychology 1998; 22: 303–16.
108. Popovic EA, Fabinyi GCA, Brazenor GA, et al. Temporal lobectomy for epilepsy: complications in 200 patients. J Clin Neurosci 1995; 2: 238–44
109. Tillwally S, Kanner AM, Leurgans S, et al. Postsurgical psychiatric complications of temporal lobectomy: a study of risk factors. Neurology 2003; 60: A118.
110. Ring HA, Moriarity J, Trimble MR. A prospective study of the early postsurgical psychiatric associations of epilepsy surgery. J Neurol Neurosurg Psychiatry 1998; 64: 601–4.
111. Blumer D, Wakhlu S, Davies K, et al. Psychiatric outcome of temporal lobectomy for epilepsy: incidence and treatment of psychiatric complications. Epilepsia 1998; 39: 478–86.
112. Bruton CJ. The Neuropathology of Temporal Lobe Epilepsy. Oxford: Oxford University Press, 1988.
113. Sperling M, Saykin A, Roberts F, et al. Occupational outcome after temporal lobectomy for refractory epilepsy. Neurology 1995; 45: 970–6.
114. Augustine E, Novelly RA, Mattson RH, et al. Occupational adjustment following neurosurgical treatment of epilepsy. Ann Neurol 1984; 15: 68–72.
115. Reeves AL, So EL, Evans RW, et al. Factors associated with work outcome after anterior temporal lobectomy for intractable epilepsy. Epilepsia 1997; 38: 689–95.
116. Lendth M, Helmstaedter C, Elger CE. Pre-and postoperative socio-economic development of 151 patients with focal epilepsies. Epilepsia 1997; 38: 1330–7.
117. Williams KL, Roth DL, Kuzniecky R, et al. Psychosocial outcome following temporal lobe surgery. J Epilepsy 1994; 7: 144–51.
118. Katz A, Award IA, Kong AK, et al. Extent of resection in temporal lobectomy for epilepsy II: memory changes and neurological complications. Epilepsia 1989; 30: 763–71.