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21 - A Meaningful Outcome

Published online by Cambridge University Press:  12 November 2022

Daniel Gibbs
Affiliation:
Emeritus of Oregon Health and Science University
Teresa H. Barker
Affiliation:
Freelance journalist and author of scientific non-fiction
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Summary

Memory loss is the familiar headliner, but one of the most insidious symptoms of Alzheimer’s disease is apathy. Not as in a casual indifference or uncaring attitude that might change if you understood more about a thing at hand. For someone with Alzheimer’s, apathy is biological, intrinsic to the disease as it affects the brain’s executive function and diminishes motivation and the capacity to make plans and follow through. It’s as if your brain has gotten the kit for caring and empathy, but with no way to assemble it – the anatomical structures and mechanisms in the brain that would do that are damaged. Apathy is considered the most common neuropsychiatric symptom of those with Alzheimer’s.

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Chapter
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A Tattoo on my Brain
A Neurologist's Personal Battle against Alzheimer's Disease
, pp. 178 - 187
Publisher: Cambridge University Press
Print publication year: 2023

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References

Chapter-references

Nobis, L, Husain, M. Apathy in Alzheimer’s disease. Current Opinion in Behavioral Sciences 2018; 22:713; https://doi.org/10.1016/j.cobeha.2017.12.007 (public access version available at www.ncbi.nlm.nih.gov/pmc/articles/PMC6095925).CrossRefGoogle ScholarPubMed
Rowland, C. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? The Washington Post June 4, 2019; www.washingtonpost.com/business/economy/pfizer-had-clues-its-blockbuster-drug-could-prevent-alzheimers-why-didnt-it-tell-the-world/2019/06/04/9092e08a-7a61-11e9-8bb7-0fc796cf2ec0_story.html.Google Scholar
Roses, AD. Apolipoprotein E alleles as risk factors in Alzheimer’s disease. Annual Review of Medicine 1996; 47:387400; https://doi.org/10.1146/annurev.med.47.1.387.CrossRefGoogle ScholarPubMed
Roses, Allen, who upset common wisdom on cause of Alzheimer’s, dies at 73. New York Times October 5, 2016; www.nytimes.com/2016/10/06/science/allen-roses-who-upset-common-wisdom-on-cause-of-alzheimers-dies-at-73.html.Google Scholar
Gibbs, DM. Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine. American Journal of Psychiatry 1992; 149(11):15891591; https://doi.org/10.1176/ajp.149.11.1589.Google ScholarPubMed

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  • A Meaningful Outcome
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.023
Available formats
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Save book to Dropbox

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  • A Meaningful Outcome
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.023
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • A Meaningful Outcome
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.023
Available formats
×