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Chapter 7 - Are Some Cases of Sudden Infant Death Syndrome Incorrectly Diagnosed as Shaken Baby Syndrome?

from Section 2 - Medicine

Published online by Cambridge University Press:  07 June 2023

By
Marta Cohen
Edited by
Keith A. Findley ,
Cyrille Rossant ,
Kana Sasakura ,
Leila Schneps ,
Waney Squier  and
Knut Wester
Keith A. Findley
Affiliation:
University of Wisconsin, Madison
Cyrille Rossant
Affiliation:
University College London
Kana Sasakura
Affiliation:
Konan University, Japan
Leila Schneps
Affiliation:
Sorbonne Université, Paris
Waney Squier
Affiliation:
John Radcliffe Hospital, Oxford
Knut Wester
Affiliation:
Universitetet i Bergen, Norway
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Summary

Sudden infant death syndrome (SIDS) is multifactorial, associated with inadequate cardiac, breathing, autonomic and/or arousal control. Although cases are usually found collapsed in the early hours of the morning, collapse can occur in daytime. If resuscitation is successful, these infants may die later (delayed SIDS). In these circumstances, hypoxic ischaemic injury to vital organs, including the central nervous system will likely develop: haemorrhages (subdural (SDH), intradural, subgaleal, subarachnoid and/or brain), oedema, spinal and/or retinal haemorrhages (RH). The SDH and encephalopathy are well described in young infants dying of natural causes, especially following successful advanced resuscitation. Infants who develop the triad of SDH, RH, and encephalopathy share many epidemiological features with infants dying of SIDS: age, male sex, prematurity, small for gestational age, young mothers, multiple births, high parity, low socioeconomic status, smoking during pregnancy, minor respiratory infections. Hence, it seems reasonable to hypothesise that there is an overlap between some features in SIDS and SBS, and that the latter may correspond to a resuscitated SIDS.

Keywords

epidemiologyrisk factorssudden infant death syndromedelayed SIDStriadALTE/BRUEgastro-oesophageal refluxhypoxia
Type
Chapter
Information
Shaken Baby Syndrome
Investigating the Abusive Head Trauma Controversy
 , pp. 129 - 137
Publisher: Cambridge University Press
Print publication year: 2023

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References

Willinger, M, James, LS, Catz, C. Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatric Pathology. 1991;11(5):677–84.CrossRefGoogle Scholar
Filiano, JJ, Kinney, HC. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: The triple-risk model. Biology of the Neonate. 1994;65:194–7.Google Scholar
Kahn, A, Sawaguchib, T, Sawaguchib, A et al. Sudden infant deaths: From epidemiology to physiology. Forensic Science International. 2002;130S:S8–S20.Google Scholar
Byard, RW, Krous, HF. Sudden infant death syndrome: Overview and update. Pediatric Developmental Pathology. 2003;6:112–27.Google Scholar
Shapiro-Mendoza, CK, Parks, S, Lambert, AE et al. The epidemiology of sudden infant death syndrome and sudden unexpected infant deaths: Diagnostic shift and other temporal changes. In SIDS sudden infant and early childhood death: The past, the present and the future. Duncan, JR, Byard, RW, eds. University of Adelaide Press, 2018, chapter 13. www.ncbi.nlm.nih.gov/books/NBK513373.Google Scholar
Her Majesty’s Stationery Office. Report of the Chief Medical Officer’s Expert Group on the Sleeping Position of Infants and Cot Death. Her Majesty’s Stationery Office, 1993Google Scholar
www.cdc.gov/sids/data.htm.Google Scholar
Shapiro-Mendoza, CK, Tomashek, KM, Anderson, RN, Wingo, J. Recent national trends in sudden, unexpected infant deaths: More evidence supporting a change in classification or reporting. American Journal of Epidemiology. 2006;163(8):762–9.CrossRefGoogle ScholarPubMed
Mehanni, M, Cullen, A, Kiberd, B et al. The current epidemiology of SIDS in Ireland. Irish Medical Journal. 2000;93(9):264–8.Google Scholar
Heron, M. Deaths: Leading causes for 2014. National vital statistics reports from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. National Vital Statistics Reports. 2016;65(5):1–96.Google Scholar
Machaalani, R, Waters, KA. Neuronal cell death in the sudden infant death syndrome brainstem and associations with risk factors. Brain. 2008;131(Pt 1):218–28.Google Scholar
Stonebridge, R, Taliano, RJ, Velilla, TD, Anthony, DC. Hypertrophy of the anterior external arcuate fasciculus: A rare variant with implications for the development of the arcuate nucleus. Front Neuroanatomy. 2020;14:595500.CrossRefGoogle ScholarPubMed
Matthews, TJ, MacDorman, MF, Thoma, ME. Infant mortality statistics from the 2013 period linked birth/infant death data set. National Vital Statistics Report. 2015;64(9):1–30.Google ScholarPubMed
Malloy, MH. Prematurity and sudden infant death syndrome: United States 2005–2007. Journal of Perinatology. 2013;33(6):470–5.Google Scholar
Sanghavi, DM. Epidemiology of sudden infant death syndrome (SIDS) for Kentucky infants born in 1990: Maternal, prenatal, and perinatal risk factors. Journal of the Kentucky Medical Association. 1995;93(7):286–90.Google Scholar
Spencer, N, Logan, S. Sudden unexpected death in infancy and socioeconomic status: A systematic review. Journal of Epidemiology and Community Health. 2004;58(5):366–73.Google Scholar
www.apa.org/pi/ses/resources/publications/children-families.Google Scholar
Haider, S. J. Racial and ethnic infant mortality gaps and socioeconomic status. Focus. 2014;31:18–20.Google Scholar
Elder, TE, Goddeeris, JH, Haider, SJ. Racial and ethnic infant mortality gaps and the role of socio-economic status. Labour Economics. 2016;43:42–54.Google Scholar
Prtak, L, Al-Adnani, M, Fenton, P et al. Contribution of bacteriology and virology in sudden unexpected death in infancy. Archive of Diseases in Childhood. 2010;95(5):371–6.Google Scholar
Krous, HF, Haas, EA, Chadwick, AE et al. Delayed death in sudden infant death syndrome: A San Diego SIDS/SUDC Research Project 15-year population-based report. Forensic Science International. 2008;176(2–3):209–16.Google Scholar
Krous, HF, Chadwick, AE, Haas, E et al. Sudden infant death while awake. Forensic Science, Medicine and Pathology. 2008;4(1):40–6.Google Scholar
Kahn, A, Blum, D, Hennart, P et al. A critical comparison of the history of sudden-death infants and infants hospitalised for near-miss for SIDS. European Journal of Pediatrics. 1984;143(2):103–7.Google Scholar
Page, M, Jeffrey, H. The role of gastro-oesophageal reflux in the aetiology of SIDS. Early Human Development. 2000;59:127–49.CrossRefGoogle ScholarPubMed
Thach, BT. Sudden infant death syndrome: Can gastroesophageal reflux cause sudden infant death? American Journal of Medicine. 2000;108:S144–S148.Google Scholar
Krous, HF, Masoumi, H, Haas, EA et al. Aspiration of gastric contents in sudden infant death syndrome without cardiopulmonary resuscitation. Journal of Pediatrics. 2007;150:241–6.Google Scholar
Alex, N, Thompson, JMD, Becroft, DMO, Mitchell, EA. Pulmonary aspiration of gastric contents and the sudden infant death syndrome. Journal of Paediatrics and Child Health. 2005;41:428–31.Google Scholar
Al-Adnani, M, Cohen, MC, Scheimberg, I. Gastroesophageal reflux disease and sudden infant death: Mechanisms behind an under-recognized association. Pediatric Development and Pathology. 2011;14(1):53–6.Google Scholar
Davies, F, Gupta, R. Apparent life threatening events in infants presenting to an emergency department. Emergency Medicine Journal. 2002;19:11–16.Google Scholar
https://bit.ly/3V83gdp.Google Scholar
https://mayocl.in/3SW5zhM.Google Scholar
Elinder, G, Eriksson, A, Hallberg, B et al. Traumatic shaking: The role of the triad in medical investigations of suspected traumatic shaking. Acta Paediatrica. 2018;107:3–23.Google Scholar
https://bit.ly/3fIYdQJ.Google Scholar
Hobbs, C, Childs, AM, Wynne, J et al. Subdural haematoma and effusion in infancy: An epidemiological study. Archive of Diseases in Childhood. 2005;90(9):952–5.CrossRefGoogle ScholarPubMed
Högberg, U, Andersson, J, Squier, W et al. Epidemiology of subdural haemorrhage during infancy: A population-based register study. PLoS One. 2018;13(10):e0206340.Google Scholar
Squier, W, Mack, J, Jansen, AC. Infants dying suddenly and unexpectedly share demographic features with infants who die with retinal and dural bleeding: A review of neural mechanisms. Developmental Medicine and Child Neurology. 2016;58(12):1223–34.CrossRefGoogle ScholarPubMed
Duhaime, AC, Christian, CW, Rorke, LB, Zimmerman, RA. Nonaccidental head injury in infants: The ‘shaken baby syndrome’. New England Journal of Medicine. 1998;338:1822–9.Google Scholar
Gerber, P, Coffman, K. Nonaccidental head trauma in infants. Child’s Nervous System 2007;23:499–507.Google Scholar
Keenan, HT, Runyan, DK, Marshall, SW et al. A population-based study of inflicted traumatic brain injury in young children. JAMA. 2003;290:621–6.Google Scholar
Oehmichen, M, Schleiss, D, Pedal, I et al. Shaken baby syndrome: Re-examination of diffuse axonal injury as cause of death. Acta Neuropathologica. 2008;116:317–29.Google Scholar
Blair, PS, Sidebotham, P, Evason-Coombe, C et al. Hazardous cosleeping environments and risk factors amenable to change: Case-control study of SIDS in south west England. BMJ.2009;13(339):b3666.Google Scholar
Mage, D, Donner, E, Vennemann, M et al. All sudden unexplained infant respiratory deaths may result from the same underlying mechanism. Scandinavian Journal of Forensic Science. 2012;18(1):1–9.Google Scholar
Moon, RY, Horne, RSC, Hauck, FR. Sudden infant death syndrome. Lancet. 2007;370:1578–87.CrossRefGoogle ScholarPubMed
Kato, I, Franco, P, Groswasser, J et al. Incomplete arousal processes in infants who were victims of sudden death. American Journal of Respiratory and Critical Care Medicine. 2003;168:1298–1303.Google Scholar
Benarroch, EE. Brainstem respiratory chemosensitivity. New insights and clinical implications. Neurology. 2007:2140–3.Google Scholar
Leiter, JC, Böhm, I. Mechanisms of pathogenesis in the sudden infant death syndrome. Respiratory Physiology and Neurobiology. 2007;159:127–38.Google Scholar
Naeye, RL. Sudden death in infants. In Potter’s pathology of the fetus, infant and child, vol. 1. Gilbert-Barness, E, ed. Elsevier, 2007, pp. 857–69.Google Scholar
Cohen, MC, Yong, CY, Evans, C et al. Release of erythroblasts to the peripheral blood suggests higher exposure to hypoxia in cases of SIDS with co-sleeping compared to SIDS non-co-sleeping. Forensic Science International. 2010;197(1–3):54–8.Google Scholar
Cohen, MC, Sprigg, A, Whitby, EH. Subdural hemorrhage, intradural hemorrhage and hypoxia in the pediatric and perinatal post mortem: Are they related? An observational study combining the use of post mortem pathology and magnetic resonance imaging. Forensic Science International. 2010;200(1–3):100–7.Google Scholar
Cohen, MC, Scheimberg, I. Evidence of occurrence of intradural and subdural hemorrhage in the perinatal and neonatal period in the context of hypoxic ischemic encephalopathy. An observational study from two referral institutions in the United Kingdom. Pediatric Development Pathology. 2009;12:169–76.Google Scholar
Scheimberg, I, Cohen, MC, Zapata Vazquez, RE et al. Nontraumatic intradural and subdural hemorrhage and hypoxic ischemic encephalopathy in fetuses, infants, and children up to three years of age: Analysis of two audits of 636 cases from two referral centers in the United Kingdom. Pediatric Developmental Pathology. 2013;16(3):149–59.Google Scholar

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