Historically, the boundaries between neurology, neuropathology and psychiatry were somewhat blurred as clinicians were encouraged to see disorders of brain and mind as arising from a common organic denominator. It was not uncommon to see psychiatrists at the microscope making landmark discoveries (Alois Alzheimer and Solomon Carter-Fuller, to name just two of them), yet the twentieth century saw these three disciplines fractionate. Neurology and neuropathology retained collaborative threads as neurology became established as the speciality of organic brain disease, while psychiatry did not regain traction as a credible medico-scientific discipline for several decades. Thankfully, the boundaries between the three disciplines are once again blurred as it has become clear that many neurological conditions include symptoms commonly recognised and treated by psychiatrists. This chapter outlines how to approach assessment and diagnosis and gives an overview of psychiatric presentations in several core neurology topics including stroke, epilepsy, Parkinson’s disease and autoimmune disorders.