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Chapter 8 - Simplified models of neurons

Published online by Cambridge University Press:  05 June 2012

David Sterratt
Affiliation:
University of Edinburgh
Bruce Graham
Affiliation:
University of Stirling
Andrew Gillies
Affiliation:
Psymetrix Limited, Edinburgh
David Willshaw
Affiliation:
University of Edinburgh
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Summary

In this chapter a range of models with fewer details than in previous chapters is considered. These simplified neuron models are particularly useful for incorporating into networks since they are computationally more efficient, and sometimes they can be analysed mathematically. Reduced compartmental models can be derived from large compartmental models by lumping together compartments. Additionally, the number of gating variables can be reduced while retaining much of the dynamical flavour of a model. These approaches make it easier to analyse the function of the model using the mathematics of dynamical systems. In the yet simpler integrate-and-fire model, there are no gating variables, action potentials being produced when the membrane potential crosses a threshold. At the simplest end of the spectrum, rate-based models communicate via firing rates rather than individual spikes.

Up until this point, the focus has been on adding details to our neuron models. In this chapter we take the apparently paradoxical step of throwing away a lot of what is known about neurons. Given all the painstaking work that goes into building detailed models of neurons, why do this? There are at least two reasons:

  1. (1) We wish to explain how a complicated neural model works by stripping it down to its bare essentials. This gives an explanatory model in which the core mechanisms have been exposed and so are easier to understand.

  2. […]

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Publisher: Cambridge University Press
Print publication year: 2011

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