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  • Print publication year: 2016
  • Online publication date: March 2016

Chapter 11 - Combination antiemetics

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5.Apfel, CC, Korttila, K, Abdalla, M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350: 2441–51.
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16.Habib, AS, El-Moalem, HE, Gan, TJ. The efficacy of the 5-HT(3) receptor antagonists combined with droperidol for PONV prophylaxis is similar to their combination with dexamethasone. A meta-analysis of randomized controlled trials. Can J Anesth 2004; 51: 311–9.
17.Shen, YD, Chen, CY, Wu, CH, et al. Dexamethasone, ondansetron, and their combination and postoperative nausea and vomiting in children undergoing strabismus surgery: a meta-analysis of randomized controlled trials. Paediatr Anaesth 2014; 24: 490–8.
18.Gralla, R, Lichinitser, M, Van Der Vegt, S, et al. Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol 2003; 14: 1570–7.
19.Kovac, AL, Eberhart, L, Kotarski, J, et al. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg 2008; 107: 439–44.
20.Bala, I, Bharti, N, Murugesan, S, et al. Comparison of palonosetron with palonosetron–dexamethasone combination for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Minerva Anestesiol 2014; 80: 779–84.
21.Park, JW, Jun, JW, Lim, YH, et al. The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting. Korean J Anesthesiol 2012; 63: 334–9.
22.Blitz, JD, Haile, M, Kline, R, et al. A randomized double blind study to evaluate efficacy of palonosetron with dexamethasone versus palonosetron alone for prevention of postoperative and postdischarge nausea and vomiting in subjects undergoing laparoscopic surgeries with high emetogenic risk. Am J Ther 2012; 19: 324–9.
23.Kazemi-Kjellberg, F, Henzi, I, Tramer, MR. Treatment of established postoperative nausea and vomiting: a quantitative systematic review. BMC Anesthesiol 2001; 1: 2.
24.Feng, PH, Chu, KS, Lu, IC, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan 2009; 47: 39.
25.Chu, CC, Shieh, JP, Tzeng, JI, et al. The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. Anesth Analg 2008; 106: 1402–6.
26.Gan, TJ, Sinha, AC, Kovac, AL, et al. A randomized, double-blind, multicenter trial comparing transdermal scopolamine plus ondansetron to ondansetron alone for the prevention of postoperative nausea and vomiting in the outpatient setting. Anesth Analg 2009; 108: 1498–504.
27.Sah, N, Ramesh, V, Kaul, B, et al. Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. J Clin Anesth 2009; 21: 249–52.
28.Jones, S, Strobl, R, Crosby, D, et al. The effect of transdermal scopolamine on the incidence and severity of postoperative nausea and vomiting in a group of high-risk patients given prophylactic intravenous ondansetron. Aana j 2006; 74: 127–32.
29.Nesek-Adam, V, Grizelj-Stojcic, E, Mrsic, V, et al. Prophylactic antiemetics for laparoscopic cholecystectomy: droperidol, metoclopramide, and droperidol plus metoclopramide. J Laparoendosc Adv Surg Tech A 2004; 14: 212–8.
30.Nesek-Adam, V, Grizelj-Stojcic, E, Rasic, Z, et al. Comparison of dexamethasone, metoclopramide, and their combination in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. Surg Endosc 2007; 21: 607–12.
31.De Oliveira, GS Jr, Castro-Alves, LJ, Chang, R, et al. Systemic metoclopramide to prevent postoperative nausea and vomiting: a meta-analysis without Fujii’s studies. Br J Anaesth 2012; 109: 688–97.
32.Wallenborn, J, Gelbrich, G, Bulst, D, et al. Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone: randomised double blind multicentre trial. BMJ 2006; 333: 324.
33.Gesztesi, Z, Scuderi, PE, White, PF, et al. Substance P (neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures. Anesthesiology 2000; 93: 931–7.
34.Altorjay, A, Melson, T, Chinachoit, T, et al. Casopitant and ondansetron for postoperative nausea and vomiting prevention in women at high risk for emesis: a phase 3 study. Arch Surg 2011; 146: 201–6.
35.Singla, NK, Singla, SK, Chung, F, et al. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and postdischarge nausea and vomiting in high-risk patients. Anesthesiology 2010; 113: 7482.
36.Lim, CS, Ko, YK, Kim, YH, et al. Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting. Korean J Anesthesiol 2013; 64: 212–7.
37.Sinha, AC, Singh, PM, Williams, NW, et al. Aprepitant’s prophylactic efficacy in decreasing postoperative nausea and vomiting in morbidly obese patients undergoing bariatric surgery. Obes Surg 2014; 24: 225–31.
38.Vallejo, MC, Phelps, AL, Ibinson, JW, et al. Aprepitant plus ondansetron compared with ondansetron alone in reducing postoperative nausea and vomiting in ambulatory patients undergoing plastic surgery. Plast Reconstr Surg 2012; 129: 519–26.
39.Lee, SJ, Lee, SM, Kim, SI, et al. The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone. Korean J Anesthesiol 2012; 63: 221–6.
40.Kawano, H, Matsumoto, T, Hamaguchi, E, et al. Antiemetic efficacy of combined aprepitant and dexamethasone in patients at high-risk of postoperative nausea and vomiting from epidural fentanyl analgesia. Minerva Anestesiol 2014
41.Green, MS, Green, P, Malayaman, SN, et al. Randomized, double-blind comparison of oral aprepitant alone compared with aprepitant and transdermal scopolamine for prevention of postoperative nausea and vomiting. Br J Anaesth 2012; 109: 716–22.
42.Lee, HK, Lee, JH, Chon, SS, et al. The effect of transdermal scopolamine plus intravenous dexamethasone for the prevention of postoperative nausea and vomiting in patients with epidural PCA after major orthopedic surgery. Korean J Anesthesiol 2010; 58: 50–5.
43.Ahmed, AB, Hobbs, GJ, Curran, JP. Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery. Br J Anaesth 2000; 85: 678–82.
44.Khalil, S, Philbrook, L, Rabb, M, et al. Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery. J Clin Anesth 1999; 11: 596600.
45.Gan, TJ, Candiotti, KA, Klein, SM, et al. Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. Can J Anaesth 2009; 56: 829–36.
46.Scuderi, PE, James, RL, Harris, L, et al. Multimodal antiemetic management prevents early postoperative vomiting after outpatient laparoscopy. Anesth Analg 2000; 91: 1408–14.
47.Habib, AS, White, WD, Eubanks, S, et al. A randomized comparison of a multimodal management strategy versus combination antiemetics for the prevention of postoperative nausea and vomiting. Anesth Analg 2004; 99: 7781.
48.Gan, TJ, Coop, A, Philip, BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondansetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesth Analg 2005; 101: 1323–9.
49.Leslie, JB, Gan, TJ. Meta-analysis of the safety of 5-HT3 antagonists with dexamethasone or droperidol for prevention of PONV. Ann Pharmacother 2006; 40: 856–72.
50.Charbit, B, Alvarez, JC, Dasque, E, et al. Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study. Anesthesiology 2008; 109: 206–12.
51.Chan, MT, Choi, KC, Gin, T, et al. The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. Anesth Analg 2006; 103: 1155–62.
52.Gupta, A, Wu, CL, Elkassabany, N, et al. Does the routine prophylactic use of antiemetics affect the incidence of postdischarge nausea and vomiting following ambulatory surgery?: A systematic review of randomized controlled trials. Anesthesiology 2003; 99: 488–95.
53.Pan, PH, Lee, SC, Harris, LC. Antiemetic prophylaxis for postdischarge nausea and vomiting and impact on functional quality of living during recovery in patients with high emetic risks: a prospective, randomized, double-blind comparison of two prophylactic antiemetic regimens. Anesth Analg 2008; 107: 429–38.
54.Rusch, D, Arndt, C, Martin, H, et al. The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting. Anaesthesia 2007; 62: 810–7.
55.Ormel, G, Romundstad, L, Lambert-Jensen, P, et al. Dexamethasone has additive effect when combined with ondansetron and droperidol for treatment of established PONV. Acta Anaesthesiol Scand 2011; 55: 1196–205.