Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-19T19:26:30.240Z Has data issue: false hasContentIssue false

Chapter 3 - Postoperative Cognitive Dysfunction

An Overview

from Section 1 - Cognitive Function in Perioperative Care

Published online by Cambridge University Press:  11 April 2019

Roderic G. Eckenhoff
Affiliation:
University of Pennsylvania
Niccolò Terrando
Affiliation:
Duke University, North Carolina
Get access
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bedford, PD. Adverse cerebral effects of anaesthesia on old people. The Lancet 1955;266:259263.CrossRefGoogle Scholar
Moller, JT, Cluitmans, P, Rasmussen, LS, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. The Lancet 1998;351:857861.Google Scholar
Nadelson, MR, Sanders, RD, Avidan, MS. Perioperative cognitive trajectory in adults. British Journal of Anaesthesiology 2014;112:440451.CrossRefGoogle ScholarPubMed
Dijkstra, JB, Jolles, J. Postoperative cognitive dysfunction versus complaints: a discrepancy in long-term findings. Neuropsychology Review 2002;12:114.CrossRefGoogle ScholarPubMed
Johnson, T, Monk, T, Rasmussen, LS, et al. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology 2002;96:13511357.CrossRefGoogle ScholarPubMed
Evered, LA, Silbert, B, Knopman, D, et al. Recommended nomenclature for perioperative cognitive disorders. British Journal of Anesthesiology 2018;121:10051012.Google Scholar
Price, CC, Garvan, CW, Monk, TG. Type and severity of cognitive decline in older adults after noncardiac surgery. Anesthesiology 2008;108:817.CrossRefGoogle ScholarPubMed
Price, CC, Tanner, JJ, Schmalfuss, I, et al. A pilot study evaluating presurgery neuroanatomical biomarkers for postoperative cognitive decline after total knee arthroplasty in older adults. Anesthesiology 2014;120:601613.Google Scholar
Monk, TG, Weldon, BC, Garvan, CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 2008;108:1830.Google Scholar
Abildstrom, H, Rasmussen, LS, Rentowl, P, et al. Cognitive dysfunction 1–2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiologica Scandinavica 2000;44:12461251.Google Scholar
Avidan, MS, Evers, AS. The fallacy of persistent postoperative cognitive decline. Anesthesiology 2016;124:255258.CrossRefGoogle ScholarPubMed
Eckenhoff, RG, Hogan, KJ, Evered, L. Fallacy … really? Anesthesiology 2016;125:426428.Google Scholar
Steinmetz, J, Christensen, KB, Lund, T, Lohse, N, Rasmussen, L, ISPOCD Group. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology 2009;110:548555.Google Scholar
Schupf, N, Tang, MX, Albert, SM, et al. Decline in cognitive and functional skills increases mortality risk in nondemented elderly. Neurology 2005;65:12181226.Google Scholar
Vutskits, L, Xie, Z. Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nature Reviews Neuroscience 2016;17:705717.Google Scholar
O’Brien, H, Mohan, H, Hare, CO, Reynolds, JV, Kenny, RA. Mind over matter? The hidden epidemic of cognitive dysfunction in the older surgical patient. Annals of Surgery 2016;265:1.Google Scholar
Newman, MF, Croughwell, ND, Blumenthal, JA, et al. Predictors of cognitive decline after cardiac operation. Annals of Thoracic Surgery 1995;59:13261330.CrossRefGoogle ScholarPubMed
McDonagh, DL, Mathew, JP, White, WD, et al. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology 2010;112:852859.CrossRefGoogle ScholarPubMed
Martucci, KT, Mackey, SC. Imaging pain. Anesthesiology Clinics 2016;34:255269.CrossRefGoogle ScholarPubMed
Vaurio, LE, Sands, LP, Wang, Y, Mullen, EA, Leung, JM. Postoperative delirium: the importance of pain and pain management. Anesthesia & Analgesia 2006;102:12671273.CrossRefGoogle ScholarPubMed
Culley, DJ, Flaherty, D, Reddy, S, et al. Preoperative cognitive stratification of older elective surgical patients: a cross-sectional study. Anesthesia & Analgesia 2016;123:186192.Google Scholar
Culley, DJ, Flaherty, D, Fahey, MC, et al. Poor performance on a preoperative cognitive screening test predicts postoperative complications in older orthopedic surgical patients. Anesthesiology 2017;127:765774.Google Scholar
Leslie, M. The post-op brain. Science 2017;356:898900.Google Scholar
Sprung, J, Roberts, RO, Weingarten, TN, et al. Postoperative delirium in elderly patients is associated with subsequent cognitive impairment. British Journal of Anaesthesiology 2017;119:316323.CrossRefGoogle ScholarPubMed
Franck, M, Nerlich, K, Neuner, B, et al. No convincing association between post-operative delirium and post-operative cognitive dysfunction: a secondary analysis. Acta Anaesthesiologica Scandinavica 2016;60:14041414.Google Scholar
Culley, DJ, Crosby, G. Prehabilitation for prevention of postoperative cognitive dysfunction? Anesthesiology 2015;123:1.CrossRefGoogle ScholarPubMed
McDonald, SR, Heflin, MT, Whitson, HE, et al. Association of integrated care coordination with postsurgical outcomes in high-risk older adults: the Perioperative Optimization of Senior Health (POSH) initiative. JAMA Surgery 2018;153:454462.CrossRefGoogle ScholarPubMed
Cibelli, M, Fidalgo, AR, Terrando, N, et al. Role of interleukin-1beta in postoperative cognitive dysfunction. Annals of Neurology 2010;68:360368.Google Scholar
Fidalgo, AR, Cibelli, M, White, JPM, Nagy, I, Maze, M, Ma, D. Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neuroscience Letters 2011;498:6366.CrossRefGoogle ScholarPubMed
Terrando, N, Monaco, C, Ma, D, Foxwell, BMJ, Feldmann, M, Maze, M. Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline. Proceedings of the National Academy of Sciences of the United States of America 2010;107:2051820522.Google Scholar
Fidalgo, AR, Cibelli, M, White, JPM, et al. Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse. Neuroscience 2011;190:194199.Google Scholar
Canet, J, Raeder, J, Rasmussen, LS, et al. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiologica Scandinavica 2003;47:12041210.CrossRefGoogle ScholarPubMed
Evered, L, Scott, DA, Silbert, B, Maruff, P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesthesia & Analgesia 2011;112:11791185.CrossRefGoogle ScholarPubMed
Newman, MF, Kirchner, JL, Phillips-Bute, B, et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. New England Journal of Medicine 2001;344:395402.Google Scholar
van Dijk, D, Spoor, M, Hijman, R, et al. Cognitive and cardiac outcomes 5 years after off-pump vs. on-pump coronary artery bypass graft surgery. JAMA 2007;297:701708.Google Scholar
Abdul-Jawad Altisent, O, Ferreira-Gonzalez, I, Marsal, JR, et al. Neurological damage after transcatheter aortic valve implantation compared with surgical aortic valve replacement in intermediate risk patients. Clinical Research in Cardiology 2016;105:508517.Google Scholar
Selnes, OA, Grega, MA, Borowicz, LM, Royall, RM, McKhann, GM, Baumgartner, WA. Cognitive changes with coronary artery disease: a prospective study of coronary artery bypass graft patients and nonsurgical controls. Annals of Thoracic Surgery 2003;75:137784.Google Scholar
Selnes, OA, Grega, MA, Bailey, MM, et al. Do management strategies for coronary artery disease influence 6-year cognitive outcomes? Annals of Thoracic Surgery 2009;88:445454.Google Scholar
Forsberg, A, Cervenka, S, Jonsson Fagerlund, M, et al. The immune response of the human brain to abdominal surgery. Annals of Neurology 2017;81:572582.Google Scholar
Choi, HA. The brain’s immune system hibernates in response to systemic injury. Science Translational Medicine 2017;9:eaan2771.Google Scholar
Culley, DJ, Baxter, M, Yukhananov, R, Crosby, G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesthesia & Analgesia 2003;96:10041009.Google Scholar
Xie, Z, Culley, DJ, Dong, Y, et al. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid-beta protein level in vivo. Annals of Neurology 2008;64:618627.Google Scholar
Planel, E, Bretteville, A, Liu, L, et al. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB Journal 2009;23:25952604.Google Scholar
Futterer, CD, Maurer, MH, Schmitt, A, Feldmann, RE Jr., Kuschinsky, W, Waschke, KF. Alterations in rat brain proteins after desflurane anesthesia. Anesthesiology 2004;100:302308.CrossRefGoogle ScholarPubMed
Rasmussen, LS, Johnson, T, Kuipers, HM, et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiologica Scandinavica 2003;47:260266.CrossRefGoogle ScholarPubMed
Sieber, FE, Gottshalk, A, Zakriya, KJ, Mears, SC, Lee, H. General anesthesia occurs frequently in elderly patients during propofol-based sedation and spinal anesthesia. Journal of Clinical Anesthesiology 2010;22:179183.Google Scholar
Purdon, PL, Pavone, KJ, Akeju, O, et al. The ageing brain: age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. British Journal of Anaesthesiology 2015;115:4657.Google Scholar
Silbert, BS, Evered, LA, Scott, DA. Incidence of postoperative cognitive dysfunction after general or spinal anaesthesia for extracorporeal shock wave lithotripsy. British Journal of Anaesthesiology 2014;113:784791.CrossRefGoogle ScholarPubMed
Chan, MT, Cheng, BC, Lee, TM, Gin, T, CODA Trial Group. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. Journal of Neurosurgery & Anesthesiology 2013;25:3342.Google Scholar
Sprung, J, Roberts, RO, Knopman, DS, et al. Association of mild cognitive impairment with exposure to general anesthesia for surgical and nonsurgical procedures: a population-based study. Mayo Clinic Proceedings 2016;91:208217.Google Scholar
Sprung, J, Jankowski, CJ, Roberts, RO, et al. Anesthesia and incident dementia: a population-based, nested, case-control study. Mayo Clinic Proceedings 2013;88:552561.Google Scholar
Sprung, J, Roberts, RO, Knopman, DS, et al. Mild cognitive impairment and exposure to general anesthesia for surgeries and procedures: a population-based case-control study. Anesthesia & Analgesia 2017;124:12771290.Google Scholar
Hughes, CG, Patel, MB, Jackson, JC, et al. Surgery and anesthesia exposure is not a risk factor for cognitive impairment after major noncardiac surgery and critical illness. Annals of Surgery 2016;265:11261133.Google Scholar
Aiello Bowles, EJ, Larson, EB, Pong, RP, et al. Anesthesia exposure and risk of dementia and Alzheimer’s disease: a prospective study. Journal of the American Geriatrics Society 2016;64:602607.Google Scholar
Seitz, DP, Shah, PS, Herrmann, N, Beyene, J, Siddiqui, N. Exposure to general anesthesia and risk of Alzheimer’s disease: a systematic review and meta-analysis. BMC Geriatrics 2011;11:83.Google Scholar
Dokkedal, U, Hansen, TG, Rasmussen, LS, Mengel-From, J, Christensen, K. Cognitive functioning after surgery in middle-aged and elderly Danish twins. Anesthesiology 2016;124:312321.Google Scholar
Hogan, KJ, Bratzke, LC, Hogan, KL. Informed consent and cognitive dysfunction after noncardiac surgery in the elderly. Anesthesia & Analgesia 2018;126:629631.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×