Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Chapter 29 Neuronal Death
- Chapter 30 Macroglial Reactions
- Chapter 31 Inflammatory Responses
- Gray Matter
- White Matter
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 31 - Inflammatory Responses
from Cellular Responses
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Chapter 29 Neuronal Death
- Chapter 30 Macroglial Reactions
- Chapter 31 Inflammatory Responses
- Gray Matter
- White Matter
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
The development of the human immune system and responses have been reviewed in detail by others (1–3). Monocytes/macrophages, the earliest circulating immune cells, appear at the beginning of the fetal period. They are followed by neutrophils, lymphocyte precursors, and natural killer (NK) cells by gestational week 8–10, and then naïve T and B lymphocytes at week 12. The thymus (the source of T cells) grows rapidly during gestational weeks 7–14 and continues to grow, reaching its maximum size by the end of the first year of life, after which it involutes eventually replaced by fat at puberty (4).
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- Perinatal Neuropathology , pp. 159 - 164Publisher: Cambridge University PressPrint publication year: 2021