Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Neural Tube Defects and Patterning Defects
- Hydrocephalus
- Neuronal Migration Disorders
- Chapter 40 Cerebral Cortical Migration Disorders
- Genetic Syndromes and Phakomatoses
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 40 - Cerebral Cortical Migration Disorders
from Neuronal Migration Disorders
Published online by Cambridge University Press: 07 August 2021
Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Neural Tube Defects and Patterning Defects
- Hydrocephalus
- Neuronal Migration Disorders
- Chapter 40 Cerebral Cortical Migration Disorders
- Genetic Syndromes and Phakomatoses
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
Neuronal migration disorders (NMDs) constitute a group of cerebral disorders caused by early developmental disturbances of or by primary genetic defects in the migration of newly born neurons to their final location where they settle into their proper neural circuits. Neuronal migration begins in the second gestational month and is driven by a cascade of complex chemical signals. When these signaling pathways are deficient or interrupted (e.g., by a hypoxic-ischemic event), the neurons do not migrate to the proper areas of the brain. This failure of normal signaling results in structurally abnormal or completely absent brain regions, including in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. NMDs involving the cerebral cortex are characterized by abnormal lamination and folding.
- Type
- Chapter
- Information
- Perinatal Neuropathology , pp. 243 - 254Publisher: Cambridge University PressPrint publication year: 2021
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