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Chapter 1 - Development of Hematopoiesis in the Fetus, at Birth, and after Birth

from Section I - General Hematology and Hematopathology

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Hematopoiesis is a complex process encompassing the continuous generation of specialized, mature blood cells from pluripotent hematopoietic stem cells (HSCs). The hematopoietic system is not fully developed at birth. The proportion of bone marrow (BM) components and normal hematologic values for neonates, infants, older children, and adults are different as a result of the unique characteristics of embryonal and fetal development of the hematopoietic system, which continues to evolve after birth [1]. Knowledge of these differences is essential to distinguish normal development from a pathologic process when evaluating blood and BM in pediatric patients.

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 1 - 4
Publisher: Cambridge University Press
Print publication year: 2024

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References

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