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Chapter 30 - Schizophrenia in Pregnancy

from Section 5 - Psychiatric Disorders in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi  and
Nicolas Beaulieu
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 30-year-old primigravida with schizophrenia is referred by her primary care provider to your high-risk obstetrics unit at a tertiary center. Her mental illness is controlled by clozapine, and she takes routine prenatal vitamins. The patient is at 12+2 weeks’ gestation by dating sonography; first-trimester fetal anatomy was normal with a low risk of aneuploidy. Results of routine prenatal investigations are unremarkable. The patient does not have any obstetric complaints.

Keywords

Schizophrenia, pregnancyAntipsychoticsInvestigationsClozapine, maternal and fetal risksAntenatal managementAcute psychosisInformed consentPostpartum care
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 397 - 406
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

ACOG Committee on Practice Bulletins – Obstetrics. ACOG Practice Bulletin: Clinical management guidelines for obstetrician-gynecologists No. 92. Use of psychiatric medications during pregnancy and lactation. Obstet Gynecol. 2008;111(4):1001–1020.Google Scholar
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Jones, I, Chandra, PS, Dazzan, P, et al. Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period. The Lancet. 2014 Nov 15;384(9956):1789–1799.Google Scholar
Poo, SX, Agius, M. Atypical antipsychotics for schizophrenia and/or bipolar disorder in pregnancy: current recommendations and updates in the NICE guidelines. Psychiatr Danub. 2015;27(Suppl 1):S255–S260.Google Scholar
Rasic, D, Hajek, T, Alda, M, et al. Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. Schizophr Bull. 2014;40(1):28–38.CrossRefGoogle ScholarPubMed
Robinson, GE. Treatment of schizophrenia in pregnancy and postpartum. J Popul Ther Clin Pharmacol. 2012;19(3):e380–e386.Google Scholar

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