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Chapter 13 - Perioperative Monitoring for Congenital Heart Disease Surgery

from Part IV - Practice of Neuromonitoring: Cardiac Intensive Care Unit

Published online by Cambridge University Press:  08 September 2022

Cecil D. Hahn
Affiliation:
The Hospital for Sick Children, University of Toronto
Courtney J. Wusthoff
Affiliation:
Lucile Packard Children’s Hospital, Stanford University
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Summary

Congenital heart disease (CHD) encompasses a large collection of cardiac malformations discovered at or before birth. CHD has an incidence of 4 – 50/1000 live births annually. One quarter of these require surgery shortly after birth. Newborn heart surgery has substantially changed since the modern era began with the adaptation of adult cardiopulmonary bypass (CPB) circuitry for infants. After decades of progress, the center of focus has now shifted from survival to the quality of life following newborn heart surgery (NBHS). Indeed, neurodevelopmental disabilities are now considered the single most common sequela of NBHS. Clinical management in the peri-operative period has a significant impact on the infants’ long-term outcomes. Consequently, neurological monitoring in the congenital heart disease population is increasing worldwide. With so many infants undergoing NBHS, the field of neuromonitoring for these patients is wide. In this chapter, we first review the neurological effects of hypothermia and the actual conduct of newborn heart surgery. We then discuss the indications for neuromonitoring and summarize its findings and outcomes in this unique population.

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Publisher: Cambridge University Press
Print publication year: 2022

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References

Hoffman, JI, Kaplan, S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–900.Google Scholar
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention. Congenital heart defects. 2015. www.cdc.gov/ncbddd/heartdefects/data.htmlGoogle Scholar
Rosomoff, HL. Pathophysiology of the central nervous system during hypothermia. Acta Neurochir Suppl. 1964;14(Suppl 13):1122.Google ScholarPubMed
Nakagawa, TA, Ashawal, S, Mathur, M, et al. Guidelines for the determination of brain death in infants and children: an update of the 1987 Task Force recommendations. Crit Care Med. 2011;39(9):2139–55.Google Scholar
Follis, MW. Neurologic/myocardial protection during pediatric cardiac surgery. Medscape. 2015. http://emedicine.medscape.com/article/902765-overviewGoogle Scholar
Newburger, JW, Jones, RA, Wernovsky, G, et al. A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med. 1993;329(15):1057–64.CrossRefGoogle ScholarPubMed
Helmers, SL, Wypij, D, Constantinou, JE, et al. Perioperative electroencephalographic seizures in infants undergoing repair of complex congenital cardiac defects. Electroencephalogr Clin Neurophysiol. 1997;102(1):2736.Google Scholar
Wang, H, Wang, B, Normoyle, KP, et al. Brain temperature and its fundamental properties: a review for clinical neuroscientists. Front Neurosci. 2014; 8: 307.CrossRefGoogle ScholarPubMed
Vossough, A, Limperopoulos, C, Putt, ME, et al. Development and validation of a semiquantitative brain maturation score on fetal MR images: initial results. Radiology. 2013;268(1):200–7.CrossRefGoogle ScholarPubMed
Licht, DJ, Shera, DM, Clancy, RR, et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg. 2009;137(3):529–36; discussion 536–7.CrossRefGoogle ScholarPubMed
Abdel Raheem, MM, Mohamed, WA. Impact of congenital heart disease on brain development in newborn infants. Ann Pediatr Cardiol. 2012;5(1):21–6.Google Scholar
Miller, SP, McQuillen, PS, Hamrick, S, et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med. 2007;357(19): 1928–38.Google Scholar
Harden, A, Pampiglione, G, Waterston, DJ. Circulatory arrest during hypothermia in cardiac surgery: an E.E.G. study in children. Br Med J. 1966;2(5522):1105–8.CrossRefGoogle ScholarPubMed
Stecker, MM, Cheung, AT, Pochettino, A, et al. Deep hypothermic circulatory arrest: II. Changes in electroencephalogram and evoked potentials during rewarming. Ann Thorac Surg. 2001;71(1):22–8.Google Scholar
Seltzer, LE, Swartz, M, Kwon, JM, et al. Intraoperative electroencephalography predicts postoperative seizures in infants with congenital heart disease. Pediatr Neurol. 2014;50(4):313–7.CrossRefGoogle ScholarPubMed
Schmitt, B, Finckh, B, Christen, S, et al. Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable? Pediatr Res. 2005; 58(4):771–8.CrossRefGoogle ScholarPubMed
Massey, SL, Abend, NS, Gaynor, JW, et al. Electroencephalographic patterns preceding cardiac arrest in neonates following cardiac surgery. Resuscitation. 2019;144:6774.Google Scholar
Murray, DM, Boylan, B, Ali, I, et al. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93(3):F187–91.Google Scholar
Scher, MS. Neonatal seizures and brain damage. Pediatr Neurol. 2003;29(5):381–90.Google Scholar
Scher, MS, Alvin, J, Gaus, L, Minnigh, B, Painter, MJ. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol. 2003;28(4):277–80.Google Scholar
Glass, HC, Shellhaas, RA, Wusthoff, CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr. 2016;174:98103.CrossRefGoogle ScholarPubMed
Connell, J, Oozeer, R, De Vries, L, et al. Clinical and EEG response to anticonvulsants in neonatal seizures. Arch Dis Child. 1989;64(4 Spec No):459–64.CrossRefGoogle ScholarPubMed
Naim, MY, Gaynor, JW, Chen, J, et al. Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2015;150(1):169–78; discussion 178–80.CrossRefGoogle ScholarPubMed
Hahn, JS, Vaucher, Y, Bejar, R, Coen, RW. Electroencephalographic and neuroimaging findings in neonates undergoing extracorporeal membrane oxygenation. Neuropediatrics. 1993;24(1):1924.Google Scholar
Malone, A, Ryan, CA, Fitzgerald, A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia. 2009;50(9):2097–101.Google Scholar
Abend, NS, Dlugos, DJ, Clancy, RR. A review of long-term EEG monitoring in critically ill children with hypoxic-ischemic encephalopathy, congenital heart disease, ECMO, and stroke. J Clin Neurophysiol. 2013;30(2):134–42.Google Scholar
Glauser, TA, Rorke, LB, Weinberg, PM, Clancy, RR. Acquired neuropathologic lesions associated with the hypoplastic left heart syndrome. Pediatrics. 1990;85(6):9911000.CrossRefGoogle ScholarPubMed
Clancy, RR, McGaurn, SA, Goin, JE, et al. Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. Pediatrics. 2001 108(1):6170.CrossRefGoogle ScholarPubMed
Clancy, RR, McGaurn, SA, Wernovsky, G, et al. Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest. Pediatrics. 2003;111(3):592601.Google Scholar
Clancy, RR, Sharif, U, Ichord, R, et al. Electrographic neonatal seizures after infant heart surgery. Epilepsia. 2005;46(1):8490.Google Scholar
Shellhaas, RA, Chang, T, Tsuchida, T, et al. The American Clinical Neurophysiology Society’s Guideline on Continuous Electroencephalography Monitoring in Neonates. J Clin Neurophysiol. 2011;28(6):611–17.CrossRefGoogle ScholarPubMed
Backer, CL, Marino, BS. Protecting the neonatal brain: finding, treating, and preventing seizures. J Thorac Cardiovasc Surg. 2015;150(1):67.CrossRefGoogle ScholarPubMed
du Plessis, AJ, Jonas, RA, Wypij, D, et al. Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Cardiovasc Surg. 1997;114(6):9911000; discussion 1000–1.Google Scholar
Gaynor, JW, Nicolson, SC, Jarvik, GP, et al. Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures. J Thorac Cardiovasc Surg. 2005;130(5):1278–86.Google Scholar
Andropoulos, DB, Mizrahi, EM, Hrachovy, RA, et al. Electroencephalographic seizures after neonatal cardiac surgery with high-flow cardiopulmonary bypass. Anesth Analg. 2010;110(6):1680–5.Google Scholar
Gunn, JK, Beca, J, Penny, DJ, et al. Amplitude-integrated electroencephalography and brain injury in infants undergoing Norwood-type operations. Ann Thorac Surg. 2012;93(1):170–6.CrossRefGoogle ScholarPubMed
Frenkel, N, Friger, M, Meledin, I, et al. Neonatal seizure recognition–comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings. Clin Neurophysiol. 2011;122(6):1091–7.CrossRefGoogle ScholarPubMed
Rennie, JM, Chorley, G, Boylan, GB, et al. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed. 2004;89(1):F3740.CrossRefGoogle ScholarPubMed
Shah, DK, Mackay, MT, Lavery, S, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146–54.Google Scholar
Shellhaas, RA, Clancy, RR. Characterization of neonatal seizures by conventional EEG and single-channel EEG. Clin Neurophysiol. 2007;118(10):2156–61.CrossRefGoogle ScholarPubMed
Shellhaas, RA, Soaita, AI, Clancy, RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics. 2007;120(4):770–7.Google Scholar
Shellhaas, RA, Gallagher, PR, Clancy, RR. Assessment of neonatal electroencephalography (EEG) background by conventional and two amplitude-integrated EEG classification systems. J Pediatr. 2008;153(3):369–74.Google Scholar
Boylan, G, Burgoyne, L, Moore, C, O’Flaherty, B, Rennie, JM. An international survey of EEG use in the neonatal intensive care unit. Acta Paediatr. 2010;99(8):1150–5.CrossRefGoogle ScholarPubMed
Clancy, RR, Bergqvist, AGC, Dlugos, DJ, Nordli, DR, Jr. Normal pediatric EEG: neonates and children. In Ebersole, JS, Nordli, D, Jr., editors. Current Practice of Clinical Electroencephalography. Philadelphia: Wolters Kluwer Health; 2014, pp. 125212.Google Scholar
Clancy, RR, Dicker, L, Cho, S, et al. Agreement between long-term neonatal background classification by conventional and amplitude-integrated EEG. J Clin Neurophysiol. 2011;28(1):19.Google Scholar
Clancy, RR. Summary proceedings from the neurology group on neonatal seizures. Pediatrics. 2006;117(3 Pt 2):S23–7.Google Scholar
Painter, MJ, Scher, MS, Stein, AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341(7):485–9.Google Scholar
Boylan, GB, Rennie, JM, Chorley, G, et al. Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study. Neurology. 2004;62(3):486–8.Google Scholar
Shany, E, Benzaqen, O, Watemberg, N. Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. J Child Neurol. 2007;22(3):255–9.CrossRefGoogle ScholarPubMed
Castro Conde, JR, Hernández Borges, A, Doménech Martinez, E, et al. Midazolam in neonatal seizures with no response to phenobarbital. Neurology. 2005;64(5):876–9.Google Scholar
Sirsi, D, Nangia, S, LaMothe, J, et al. Successful management of refractory neonatal seizures with midazolam. J Child Neurol. 2008;23(6):706–9.Google Scholar
Abend, NS, Gutierrez-Colina, AM, Monk, HM, et al. Levetiracetam for treatment of neonatal seizures. J Child Neurol. 2011;26(4):465–70.Google Scholar
Khan, O, Chang, E, Cipriani, C, et al. Use of intravenous levetiracetam for management of acute seizures in neonates. Pediatr Neurol. 2011;44(4):265–9.CrossRefGoogle ScholarPubMed
Khan, O, Cipriani, C, Wright, C, et al. Role of intravenous levetiracetam for acute seizure management in preterm neonates. Pediatr Neurol. 2013;49(5):340–3.Google Scholar
Glass, HC, Poulin, C, Shevell, MI. Topiramate for the treatment of neonatal seizures. Pediatr Neurol. 2011; 44(6):439–42.CrossRefGoogle ScholarPubMed
Riesgo, R., Winckler, MI, Ohlweiler, L, et al. Treatment of refractory neonatal seizures with topiramate. Neuropediatrics. 2012;43(6):353–6.Google ScholarPubMed
Booth, D, Evans, DJ. Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev. 2004(4):CD004218.Google Scholar
Sicca, F, Contaldo, A, Rey, E, Dulac, O. Phenytoin administration in the newborn and infant. Brain Dev. 2000;22(1):3540.Google Scholar
Thibault, C, Naim, MY, Abend, NS, et al. A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. Epilepsia. 2020;61(4):627635.CrossRefGoogle ScholarPubMed
McQuillen, PS, Goff, DA, Licht, DJ. Effects of congenital heart disease on brain development. Prog Pediatr Cardiol. 2010;29(2):7985.CrossRefGoogle ScholarPubMed
Clancy, RR. The neurology of hypoplastic left heart syndrome. In Rychik, JW, Wernovsky, G, editors. Hypoplastic Left Heart Syndrome. New York:Springer;2003, pp. 251–72.Google Scholar
Fountain, DM, Schaer, M, Mutlu, AK, et al. Congenital heart disease is associated with reduced cortical and hippocampal volume in patients with 22q11.2 deletion syndrome. Cortex. 2014;57:128–42.Google Scholar
Mulkey, SB, OU, X, Ramakrishnaiah, RH, et al. White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study. Pediatr Neurol. 2014;51(3):377–83.Google Scholar
Cheong, JL, Thompson, DK, Spittle, AJ, et al. Brain volumes at term-equivalent age are associated with 2-year neurodevelopment in moderate and late preterm children. J Pediatr. 2016;174:91–7.CrossRefGoogle ScholarPubMed
Birca, A, Vakorin, FA, Porayette, P, et al. Interplay of brain structure and function in neonatal congenital heart disease. Ann Clin Transl Neurol. 2016;3(9):708–22.CrossRefGoogle ScholarPubMed
Andropoulos, DB, Hunter, JV, Nelson, DP, et al. Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg. 2010;139(3):543–56.Google Scholar
Seltzer, L, Swartz, MF, Kwon, J, et al. Neurodevelopmental outcomes after neonatal cardiac surgery: Role of cortical isoelectric activity. J Thorac Cardiovasc Surg. 2016;151(4):1137–42.Google Scholar
Gaynor, JW, Jarvik, GP, Bernbaum, J, et al. The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg. 2006;131(1):181–9.Google Scholar
Gaynor, JW, Jarvik, GP, Gerdes, M, et al. Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy. J Thorac Cardiovasc Surg. 2013;146(1):132–7.CrossRefGoogle ScholarPubMed
Rappaport, LA, Wypij, D, Bellinger, DC, et al. Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group. Circulation. 1998;97(8):773–9.Google Scholar
Bellinger, DC, Wypij, D, Kuban, KC, et al. Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation. 1999;100(5):526–32.Google Scholar
Bellinger, DC, Wypij, D, Rivkin, MJ, et al. Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure: neuropsychological assessment and structural brain imaging. Circulation. 2011;124(12):1361–9.Google Scholar
Kansy, A, Tobota, A, Maruszewski, P, Maruxzewski, B. Analysis of 14,843 neonatal congenital heart surgical procedures in the European Association for Cardiothoracic Surgery Congenital Database. Ann Thorac Surg. 2010;89(4):1255–9.CrossRefGoogle Scholar
Hirsch, JC, Jacobs, ML, Andropoulos, D, et al. Protecting the infant brain during cardiac surgery: a systematic review. Ann Thorac Surg. 2012;94(4):1365–73; discussion 1373.CrossRefGoogle ScholarPubMed
Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH; NEOLEV2 INVESTIGATORS. Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. Pediatrics. 2020 Jun;145(6):e20193182. doi: 10.1542/peds.2019-3182. Epub 2020 May 8. Erratum in: Pediatrics. 2021 Jan;147(1): PMID: 32385134; PMCID: PMC7263056.CrossRefGoogle Scholar

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