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    Kalmbach, David A. Anderson, Jason R. and Drake, Christopher L. 2018. The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders. Journal of Sleep Research, Vol. 27, Issue. 6, p. e12710.

  • Print publication year: 2013
  • Online publication date: March 2013

Chapter 23 - Imaging causes and consequences of insomnia and sleep complaints

from Section 5 - Neuroimaging of sleep disorders


This chapter reviews functional neuroimaging studies in animals and humans aimed at better understanding the peculiar cerebral mode. It presents evidence that brain activity during rapid eye movement (REM) sleep is influenced by previous experience, suggesting the participation of REM sleep in memory consolidation. Functional neuroimaging research specifically devoted to the characterization of dream correlates has been conducted only during REM sleep. Indeed, mentation during REM sleep is more abundant, vivid, and story-like and hence more detailed dream reports can be obtained from REM than from slow-wave sleep. Motor behavior and movements probably activate motor-related brain areas during REM sleep. A growing body of data indicates that patterns of neural activity prevailing during sleep support offline processing of newly acquired information. The chapter concludes with comments on the difficulty in interpreting functional imaging of REM sleep in terms of neural correlates of dreaming.
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Neuroimaging of Sleep and Sleep Disorders
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1. RiemannD, SpiegelhalderK, EspieC, et al. Chronic insomnia: clinical and research challenges–an agenda. Pharmacopsychiatry. 2011;44:1–14.
2. BaglioniC, BattaglieseG, FeigeB, et al. Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135:10–19.
3. BorbélyAA. A two process model of sleep regulation. Hum Neurobiol. 1982;1:195–204.
4. DaanS, BeersmaDG, BorbelyAA. Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol. 1984;246:R161–83.
5. DijkDJ, CzeislerCA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci. 1995;15:3526–38.
6. MistlbergerRE. Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus. Brain Res Rev. 2005;49:429–54.
7. SaperCB, ScammellTE, LuJ. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437:1257–63.
8. LackLC, GradisarM, Van SomerenEJW, WrightHR, LushingtonK. The relationship between insomnia and body temperatures. Sleep Med Rev. 2008;12:307–17.
9. SwaabDF, FliersE, PartimanTS. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res. 1985;342:37–44.
10. Van SomerenEJW, Riemersma-Van Der LekRF. Live to the rhythm, slave to the rhythm. Sleep Med Rev. 2007;11:465–84.
11. HarperDG, StopaEG, Kuo-LeblancV, et al. Dorsomedial scn neuronal subpopulations subserve different functions in human dementia. Brain. 2008;131:1609–17.
12. HuK, Van SomerenEJW, SheaSA, ScheerFA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer’s disease: involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009;106:2490–4.
13. VimalRL, Pandey-VimalMU, VimalLS, et al. Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day. Eur J Neurosci. 2009;29:399–410.
14. SchmidtC, ColletteF, LeclercqY, et al. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science. 2009;324:516–19.
15. AchermannP, DijkDJ, BrunnerDP, BorbelyAA. A model of human sleep homeostasis based on eeg slow-wave activity: quantitative comparison of data and simulations. Brain Res Bull. 1993;31:97–113.
16. LeemburgS, VyazovskiyVV, OlceseU, et al. Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A.2010;107:15939–44.
17. Van SomerenEJW. Doing with less sleep remains a dream. Proc Natl Acad Sci U S A.2010;107:16003–4.
18. TononiG, CirelliC. Sleep function and synaptic homeostasis. Sleep Med Rev. 2006;10:49–62.
19. KruegerJM, ClintonJM, WintersBD, et al. Involvement of cytokines in slow wave sleep. Prog Brain Res. 2011;193:39–47.
20. Porkka-HeiskanenT, StreckerRE, ThakkarM, et al. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 1997;276:1265–8.
21. ReteyJV, AdamM, HoneggerE, et al. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A.2005;102:15676–81.
22. RomeijnN, RaymannRJEM, MøstE, et al. Sleep, vigilance and thermosensitivity. Pflügers Arch. 2012;463:169–76.
23. Fortier-BrochuE, Beaulieu-BonneauS, IversH, MorinCM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev. 2011;16:83–94.
24. HorneJA. Sleep loss and “divergent” thinking ability. Sleep. 1988;11:528–36.
25. LimJ, DingesDF. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull. 2010;136:375–89.
26. FranklandPW, BontempiB. Fast track to the medial prefrontal cortex. Proc Natl Acad Sci U S A. 2006;103:509–10.
27. TakashimaA, PeterssonKM, RuttersF, et al. Declarative memory consolidation in humans: a prospective functional magnetic resonance imaging study. Proc Natl Acad Sci U S A. 2006;103:756–61.
28. AstillRG, van der HeijdenKB, van IjzendoornMH, Van SomerenEJW. Sleep, cognition and behavioral problems in school-aged children: a century of research meta-analyzed. Psychol bull. 2012; (in press).
29. RiemannD, VoderholzerU, SpiegelhalderK, et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep. 2007;30:955–8.
30. VidebechP, RavnkildeB. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry. 2004;161:1957–66.
31. SmithME. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus. 2005;15:798–807.
32. NelsonMD, SaykinAJ, FlashmanLA, RiordanHJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry. 1998;55:433–40.
33. BencaRM, ObermeyerWH, ThistedRA, GillinJC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49:651–68; discussion 669–70.
34. WinkelmanJW, BensonKL, BuxtonOM, et al. Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med. 2010;11:576–82.
35. NohHJ, JooEY, KimST, et al. The relationship between hippocampal volume and cognition in patients with chronic primary insomnia. J Clin Neurol. 2012;8:130–8.
36. JooE, HongSB. Gray matter changes in brains of primary insomnia. Sleep Biol Rhythms. 2011;9:255.
37. AltenaE, VrenkenH, Van Der WerfYD, Van Den HeuvelOAV, Van SomerenEJW. Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry. 2010;67:182–5.
38. HuangZ, LiangP, JiaX, et al. Abnormal amygdala connectivity in patients with primary insomnia: evidence from resting state fMRI. Eur J Radiol. 2012;81(6):1288–95.
39. NeylanTC, MuellerSG, WangZ, et al. Insomnia severity is associated with a decreased volume of the ca3/dentate gyrus hippocampal subfield. Biol Psychiatry. 2010;68:494–6.
40. HallMH, SorecaI, MatthewsKA, KullerLH, GianarosPJ. Reported sleep duration and hippocampal gray matter volume in healthy women. Sleep. 2009;32:A3.
41. Van SomerenEJW, OostermanJ, van HartenB, et al. Sleep-wake rhythm fragmentation predicts age-related medial temporal lobe atrophy. J Sleep Res. 2008;17:S71.
42. BackhausJ, JunghannsK, BornJ, et al. Impaired declarative memory consolidation during sleep in patients with primary insomnia: influence of sleep architecture and nocturnal cortisol release. Biol Psychiatry. 2006;60:1324–30.
43. OostermanJ, Van SomerenEJW, VogelsR, et al. Fragmentation of the rest-activity rhythm predicts age-related cognitive deficits. J Sleep Res. 2009;18:129–35.
44. SzelenbergerW, NiemcewiczS. Severity of insomnia correlates with cognitive impairment. Acta Neurobiol Exp (Warsz). 2000;60:373.
45. GianarosPJ, JenningsJR, SheuLK, et al. Prospective reports of chronic life stress predict decreased gray matter volume in the hippocampus. Neuroimage. 2007;35:795–803.
46. YooSS, HuPT, GujarN, JoleszFA, WalkerMP. A deficit in the ability to form new human memories without sleep. Nat Neurosci. 2007;10:385–92.
47. Van Der WerfYD, AltenaE, SchoonheimMM, et al. Sleep benefits subsequent hippocampal functioning. Nat Neurosci. 2009;12:122–3.
48. Guzman-MarinR, SuntsovaN, StewartDR, et al. Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats. J Physiol. 2003;549:563–71.
49. TungA, TakaseL, FornalC, JacobsB. Effects of sleep deprivation and recovery sleep upon cell proliferation in adult rat dentate gyrus. Neurosci. 2005;134:721–3.
50. PoeGR, WalshCM, BjornessTE. Cognitive neuroscience of sleep. Prog Brain Res. 2010;185:1–19.
51. WinkelmanJW, BuxtonOM, JensenJE, et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008;31:1499–506.
52. AltenaE, Van Der WerfYD, Sanz-ArigitaEJ, et al. Prefrontal hypoactivation and recovery in insomnia. Sleep. 2008;31:1271–6.
53. BonnetMH, ArandDL. Hyperarousal and insomnia. Sleep Med Rev. 1997;1:97–108.
54. VincentNK, WalkerJR. Perfectionism and chronic insomnia. J Psychosom Res. 2000;49:349–54.
55. PavlovaM, BergO, GleasonR, et al. Self-reported hyperarousal traits among insomnia patients. J Psychosom Res. 2001;51:435–41.
56. LundhL-G, BromanJ-E, HettaJ, SanoonchiF. Perfectionism and insomnia. Scand J Behav Ther. 1994;23:3–18.
57. JanssonM, LintonSJ. The development of insomnia within the first year: a focus on worry. Br J Health Psychol. 2006;11:501–11.
58. SzelenbergerW, NiemcewiczS. Event-related current density in primary insomnia. Acta Neurobiol Exp (Warsz). 2001;61:299–308.
59. ChenR. Studies of human motor physiology with transcranial magnetic stimulation. Muscle Nerve suppl. 2000;9:S26–32.
60. KobayashiM, Pascual-LeoneA. Transcranial magnetic stimulation in neurology. Lancet Neurol. 2003;2:145–56.
61. KujiraiT, CaramiaMD, RothwellJC, et al. Corticocortical inhibition in human motor cortex. J Physiol. 1993;471:501–19.
62. Van Der WerfYD, AltenaE, Van DijkKD, et al. Is disturbed intracortical excitability a stable trait of chronic insomnia? A study using transcranial magnetic stimulation before and after multimodal sleep therapy. Biol Psychiatry. 2010;68:950–5.
63. KoenigsM, HollidayJ, SolomonJ, GrafmanJ. Left dorsomedial frontal brain damage is associated with insomnia. J Neurosci. 2010;30:16041–3.
64. ManesF, ParadisoS, RobinsonRG. Neuropsychiatric effects of insular stroke. J Nerv Mental Dis. 1999;187:707–12.
65. KringelbachML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005;6:691–702.
66. KringelbachML, BerridgeKC. Towards a functional neuroanatomy of pleasure and happiness. Trends Cogn Sci. 2009;13:479–87.
67. DunnBJ, ConoverK, PlourdeG, et al. Hedonic valuation during thermal alliesthesia. Proceedings of the 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain,2010.
68. RollsET, GrabenhorstF, ParrisBA. Warm pleasant feelings in the brain. Neuroimage. 2008;41:1504–13.
69. RaymannRJ, Van SomerenEJ. Diminished capability to recognize the optimal temperature for sleep initiation may contribute to poor sleep in elderly people. Sleep. 2008;31:1301–9.
70. SmithMT, PerlisML, ChengaziVU, et al. Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study. Sleep. 2002;25:325–35.
71. JohnsonDL, WiebeJS, GoldSM, et al. Cerebral blood flow and personality: a positron emission tomography study. Am J Psychiatry. 1999;156:252–7.
72. RayRD, OchsnerKN, CooperJC, et al. Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cogn Affect Behav Neurosci. 2005;5:156–68.
73. CooneyRE, JoormannJ, EugeneF, DennisEL, GotlibIH. Neural correlates of rumination in depression. Cogn Affect Behav Neurosci. 2010;10:470–8.
74. MorinCM, RodrigueS, IversH. Role of stress, arousal, and coping skills in primary insomnia. Psychosom Med. 2003;65:259–67.
75. DrakeCL, FriedmanNP, WrightKP, Jr., RothT. Sleep reactivity and insomnia: genetic and environmental influences. Sleep. 2011;34:1179–88.
76. BasishviliT, EliozishviliM, MaisuradzeL, et al. Insomnia in a displaced population is related to war-associated remembered stress. Stress Health. 2012;28:186–92.DOI: 10.1002/smi.1421.
77. Romcy-PereiraRN, Erraji-BenchekrounL, SmyrniotopoulosP, et al. Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. Physiol Behav. 2009;98:44–52.
78. FukunagaM, HorovitzSG, van GelderenP, et al. Large-amplitude, spatially correlated fluctuations in bold fMRI signals during extended rest and early sleep stages. Magn Reson Imaging. 2006;24:979–92.
79. BastienCH, Fortier-BrochuE, RiouxI, et al. Cognitive performance and sleep quality in the elderly suffering from chronic insomnia. Relationship between objective and subjective measures. J Psychosom Res. 2003;54:39–49.
80. Van SomerenEJW. Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol. 2004;29:437–44.
81. Van SomerenEJW. Mechanisms and functions of coupling between sleep and temperature rhythms. Prog Brain Res. 2006;153:309–24.
82. RaymannRJEM, Van SomerenEJW. Time-on-task impairment of psychomotor vigilance is affected by mild skin warming and changes with aging and insomnia. Sleep. 2007;30:96–103.
83. RaymannRJEM, SwaabDF, Van SomerenEJW. Skin deep: cutaneous temperature determines sleep depth. Brain. 2008;131:500–13.
84. RaymannRJEM, Van SomerenEJW. Diminished capability to recognize the optimal temperature for sleep initiation may contribute to poor sleep in elderly people. Sleep. 2008;31:1301–9.
85. Van SomerenEJW, PollmächerT, LegerD, et al. The European insomnia network. Front Neurosci. 2009;3:436.