1. , , , et al. Chronic insomnia: clinical and research challenges–an agenda. Pharmacopsychiatry. 2011;44:1–14.
2. , , , et al. Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135:10–19.
3. . A two process model of sleep regulation. Hum Neurobiol. 1982;1:195–204.
4. , , . Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol. 1984;246:R161–83.
5. , . Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci. 1995;15:3526–38.
6. . Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus. Brain Res Rev. 2005;49:429–54.
7. , , . Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437:1257–63.
8. , , , , . The relationship between insomnia and body temperatures. Sleep Med Rev. 2008;12:307–17.
9. , , . The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res. 1985;342:37–44.
10. , . Live to the rhythm, slave to the rhythm. Sleep Med Rev. 2007;11:465–84.
11. , , , et al. Dorsomedial scn neuronal subpopulations subserve different functions in human dementia. Brain. 2008;131:1609–17.
12. , , , . Reduction of scale invariance of activity fluctuations with aging and Alzheimer’s disease: involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009;106:2490–4.
13. , , , et al. Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day. Eur J Neurosci. 2009;29:399–410.
14. , , , et al. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science. 2009;324:516–19.
15. , , , . A model of human sleep homeostasis based on eeg slow-wave activity: quantitative comparison of data and simulations. Brain Res Bull. 1993;31:97–113.
16. , , , et al. Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A.2010;107:15939–44.
17. . Doing with less sleep remains a dream. Proc Natl Acad Sci U S A.2010;107:16003–4.
18. , . Sleep function and synaptic homeostasis. Sleep Med Rev. 2006;10:49–62.
19. , , , et al. Involvement of cytokines in slow wave sleep. Prog Brain Res. 2011;193:39–47.
20. , , , et al. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 1997;276:1265–8.
21. , , , et al. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A.2005;102:15676–81.
22. , , , et al. Sleep, vigilance and thermosensitivity. Pflügers Arch. 2012;463:169–76.
23. , , , . Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev. 2011;16:83–94.
24. . Sleep loss and “divergent” thinking ability. Sleep. 1988;11:528–36.
25. , . A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull. 2010;136:375–89.
26. , . Fast track to the medial prefrontal cortex. Proc Natl Acad Sci U S A. 2006;103:509–10.
27. , , , et al. Declarative memory consolidation in humans: a prospective functional magnetic resonance imaging study. Proc Natl Acad Sci U S A. 2006;103:756–61.
28. , , , . Sleep, cognition and behavioral problems in school-aged children: a century of research meta-analyzed. Psychol bull. 2012; (in press).
29. , , , et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep. 2007;30:955–8.
30. , . Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry. 2004;161:1957–66.
31. . Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus. 2005;15:798–807.
32. , , , . Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry. 1998;55:433–40.
33. , , , . Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49:651–68; discussion 669–70.
34. , , , et al. Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med. 2010;11:576–82.
35. , , , et al. The relationship between hippocampal volume and cognition in patients with chronic primary insomnia. J Clin Neurol. 2012;8:130–8.
36. , . Gray matter changes in brains of primary insomnia. Sleep Biol Rhythms. 2011;9:255.
37. , , , , . Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry. 2010;67:182–5.
38. , , , et al. Abnormal amygdala connectivity in patients with primary insomnia: evidence from resting state fMRI. Eur J Radiol. 2012;81(6):1288–95.
39. , , , et al. Insomnia severity is associated with a decreased volume of the ca3/dentate gyrus hippocampal subfield. Biol Psychiatry. 2010;68:494–6.
40. , , , , . Reported sleep duration and hippocampal gray matter volume in healthy women. Sleep. 2009;32:A3.
41. , , , et al. Sleep-wake rhythm fragmentation predicts age-related medial temporal lobe atrophy. J Sleep Res. 2008;17:S71.
42. , , , et al. Impaired declarative memory consolidation during sleep in patients with primary insomnia: influence of sleep architecture and nocturnal cortisol release. Biol Psychiatry. 2006;60:1324–30.
43. , , , et al. Fragmentation of the rest-activity rhythm predicts age-related cognitive deficits. J Sleep Res. 2009;18:129–35.
44. , . Severity of insomnia correlates with cognitive impairment. Acta Neurobiol Exp (Warsz). 2000;60:373.
45. , , , et al. Prospective reports of chronic life stress predict decreased gray matter volume in the hippocampus. Neuroimage. 2007;35:795–803.
46. , , , , . A deficit in the ability to form new human memories without sleep. Nat Neurosci. 2007;10:385–92.
47. , , , et al. Sleep benefits subsequent hippocampal functioning. Nat Neurosci. 2009;12:122–3.
48. , , , et al. Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats. J Physiol. 2003;549:563–71.
49. , , , . Effects of sleep deprivation and recovery sleep upon cell proliferation in adult rat dentate gyrus. Neurosci. 2005;134:721–3.
50. , , . Cognitive neuroscience of sleep. Prog Brain Res. 2010;185:1–19.
51. , , , et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008;31:1499–506.
52. , , , et al. Prefrontal hypoactivation and recovery in insomnia. Sleep. 2008;31:1271–6.
53. , . Hyperarousal and insomnia. Sleep Med Rev. 1997;1:97–108.
54. , . Perfectionism and chronic insomnia. J Psychosom Res. 2000;49:349–54.
55. , , , et al. Self-reported hyperarousal traits among insomnia patients. J Psychosom Res. 2001;51:435–41.
56. , , , . Perfectionism and insomnia. Scand J Behav Ther. 1994;23:3–18.
57. , . The development of insomnia within the first year: a focus on worry. Br J Health Psychol. 2006;11:501–11.
58. , . Event-related current density in primary insomnia. Acta Neurobiol Exp (Warsz). 2001;61:299–308.
59. . Studies of human motor physiology with transcranial magnetic stimulation. Muscle Nerve suppl. 2000;9:S26–32.
60. , . Transcranial magnetic stimulation in neurology. Lancet Neurol. 2003;2:145–56.
61. , , , et al. Corticocortical inhibition in human motor cortex. J Physiol. 1993;471:501–19.
62. , , , et al. Is disturbed intracortical excitability a stable trait of chronic insomnia? A study using transcranial magnetic stimulation before and after multimodal sleep therapy. Biol Psychiatry. 2010;68:950–5.
63. , , , . Left dorsomedial frontal brain damage is associated with insomnia. J Neurosci. 2010;30:16041–3.
64. , , . Neuropsychiatric effects of insular stroke. J Nerv Mental Dis. 1999;187:707–12.
65. . The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005;6:691–702.
66. , . Towards a functional neuroanatomy of pleasure and happiness. Trends Cogn Sci. 2009;13:479–87.
67. , , , et al. Hedonic valuation during thermal alliesthesia. Proceedings of the 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain,2010.
68. , , . Warm pleasant feelings in the brain. Neuroimage. 2008;41:1504–13.
69. , . Diminished capability to recognize the optimal temperature for sleep initiation may contribute to poor sleep in elderly people. Sleep. 2008;31:1301–9.
70. , , , et al. Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study. Sleep. 2002;25:325–35.
71. , , , et al. Cerebral blood flow and personality: a positron emission tomography study. Am J Psychiatry. 1999;156:252–7.
72. , , , et al. Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cogn Affect Behav Neurosci. 2005;5:156–68.
73. , , , , . Neural correlates of rumination in depression. Cogn Affect Behav Neurosci. 2010;10:470–8.
74. , , . Role of stress, arousal, and coping skills in primary insomnia. Psychosom Med. 2003;65:259–67.
75. , , , Jr., . Sleep reactivity and insomnia: genetic and environmental influences. Sleep. 2011;34:1179–88.
76. , , , et al. Insomnia in a displaced population is related to war-associated remembered stress. Stress Health. 2012;28:186–92.DOI: 10.1002/smi.1421.
77. , , , et al. Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. Physiol Behav. 2009;98:44–52.
78. , , , et al. Large-amplitude, spatially correlated fluctuations in bold fMRI signals during extended rest and early sleep stages. Magn Reson Imaging. 2006;24:979–92.
79. , , , et al. Cognitive performance and sleep quality in the elderly suffering from chronic insomnia. Relationship between objective and subjective measures. J Psychosom Res. 2003;54:39–49.
80. . Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol. 2004;29:437–44.
81. . Mechanisms and functions of coupling between sleep and temperature rhythms. Prog Brain Res. 2006;153:309–24.
82. , . Time-on-task impairment of psychomotor vigilance is affected by mild skin warming and changes with aging and insomnia. Sleep. 2007;30:96–103.
83. , , . Skin deep: cutaneous temperature determines sleep depth. Brain. 2008;131:500–13.
84. , . Diminished capability to recognize the optimal temperature for sleep initiation may contribute to poor sleep in elderly people. Sleep. 2008;31:1301–9.
85. , , , et al. The European insomnia network. Front Neurosci. 2009;3:436.