Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-18T01:34:15.969Z Has data issue: false hasContentIssue false

Chapter 51 - Functional neuroimaging: sedating medication effects

from Section 5 - Neuroimaging of sleep disorders

Published online by Cambridge University Press:  05 March 2013

By
Hans-Peter Landolt  and
Emily Urry
Edited by
Eric Nofzinger ,
Pierre Maquet  and
Michael J. Thorpy
Eric Nofzinger
Affiliation:
University of Pittsburgh
Pierre Maquet
Affiliation:
Université de Liège, Belgium
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Montefiore Medical Center, New York
Get access

Summary

This chapter focuses on neuroimaging studies investigating the effects of benzodiazepines (BDZ) and z-drugs on regional glucose metabolism and brain perfusion as measured with 15O-water (H215O)-position emission tomography (PET) and blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in wakefulness and non-rapid eye movement (NREM) sleep. The clinical effects of ligands at BDZ binding sites not only consist of sedation and sleep induction, but also include anxiolysis, seizure suppression, and muscle relaxation. The effects of pharmacological agents on regional brain activity during sleep can be investigated by employing neuroimaging and polysomnography simultaneously. Imaging findings support the concept that persistent activity in distinct arousal networks, particularly continuous activation of the precuneus, is linked to impaired sleep quality in patients with insomnia. With regards to pharmacological interventions, sedative-hypnotics may provide an antidote to the proposed central nervous system (CNS) hyperarousal seen in these patients during sleep.

Keywords

rapid eye movement sleep behavior disorderrestless legs syndromeneurochemical pathwaysParkinson's diseaseperiodic limb movementssleep disordered breathingmultiple system atrophyexcessive daytime sleepinessfunctional neuroimaging
Type
Chapter
Information
Neuroimaging of Sleep and Sleep Disorders , pp. 396 - 405
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×