Three-dimensional structure of the ATPse fragment of a 70K heat-shock cognate protein. Nature 1990, 346: 623–628, and
Structure of a new crystal form of human hsp70 ATPse domain. D. Biol. Crystallogr. 1999, D55: 1105–1107, , , and .
Structural analysis of substrate binding by the molecular chaperone DnaK. Science 1996, 272: 1606–1614, , , , , and .
Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J Immunol 2000, 164: 13–17, , , and .
Hsp70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000, 6: 435–442, , , , , , and .
CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 2001, 15: 971–983, , , , , , , , , , , and .
Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70. J Immunol 2002, 169: 2422–2429, , , , , and .
Identification of stimulating and inhibitory epitopes within the Hsp70 molecule which modulate cytokine production and maturation of dendritic cells. J Immunology 2005, 174: 3306–3316, , , , , , ,
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol 2002, 158: 1277–1285, and .
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat Med 2003, 9: 1469–1476, , , , , and .
CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity 2003, 19: 823–835, , and .
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activates the NF-κB pathway. Int Immunol 2000, 12: 1539–1546, , , and .
CD91: a receptor for heat shock protein gp96. Nat Immunol 2000, 1: 151–155, and .
Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J Immunol 2000, 164: 558–561, , and .
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001, 276: 31332–31339, , , , , and .
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 2002, 277: 15107–15112, , , , and .
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chem 2002, 277: 20847–20853, , , , , , , , , and .
The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin. Biochem Pharmacol 1999, 57: 383–386, and .
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 2002, 17: 353–362, , , , , , , , , and .
Heat shock proteins generate β-chemokines which function as innate adjuvants enhancing adaptive immunity. Eur J Immunol 2000, 30: 594–603, , , , , and .
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infect Immun 1994, 62: 5689–5693, , , and .
Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct pathways. J Exp Med 2000, 191: 1957–1964, , , , , and .
Intranuclear targeted delivery of functional NF-κB by 70kDa heat shock protein. EMBO J 1999, 18: 411–419 and .
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990, 249: 1431–1433, , , and .
Signalling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol 1999, 163: 639–643, , and .
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. J Biol Chem 2001, 276: 21129–21135, , , and .
A CD14-independent LPS receptor cluster. Nat Immunol 2001, 2: 338–344, and .
Novel signal transduction pathway utilized by extracellular HSP70. Role of Toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002, 277: 15028–15034, , , , , , and .
Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells. Eur J Immunol 2002, 32: 322–332, , , , , , , , , , , and .
Functions of CD40 on B cells, dendritic cells and other cells. Cur Opin Immunol 1997, 9: 330–337 and .
CD40 and epithelial cells: across the great divide. Immunol Today 1998, 19: 502–506, , and .
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 2002, 297: 2060–2063, and .
Help for cytotoxic-T cell responses is mediated by CD40 signalling. Nature 1998, 393: 478–480, , , , and .
T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998, 393: 480–483, , , and .
Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 1997, 159: 4150–4153, , , , , and .
CD40 ligand (CD154) stimulation of macrophages to produce HIV-1 suppressive chemokines. Proc Natl Acad Sci USA 1998, 99: 5205–5210, and .
Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms. J Immunol 1999, 162: 3711–3717, , , , , , and .
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 2002, 14: 319–329, , , , , , , , and .
Innate immune recognition. Ann Rev Immunol 2002, 20: 197–216 and .
Toll-like receptors and innate immunity. Nat Rev Immunol 2001, 1: 135–145.
Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 2004, 111: 173–178, , , and .
α2 Macroglobulin: an evolutionary conserved arm of the innate immune system. Dev Comp Immunol 1999, 23: 375–390 and .
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70 and calreticulin. Immunity 2001, 14: 303–313, , and .
Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002, 2: 185–194.
The other side of scavenger receptors: pattern recognition for host defense. Cur Opin Lipidol 1997, 8: 275–280.
The role of scavenger receptors in the innate immune system. Microbes Infect 2000, 2: 305–311 and .
Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J Immunol 2002, 168: 2997–3003, and .
HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. Immunity 2004, 20: 95–106, , , , and .
Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics 1978, 7: 17–24 and .
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (TLR4). J Exp Med 1999, 189: 615–625, , , , , and .
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol 2001, 3: 891–896 and .
Subsets of human dendritic cell precursors express different toll-like receptor and respond to different microbial antigens. J Exp Med 2001, 163: 5786–5795, , , W, and .
Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-κB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci USA 1999, 96: 1421–1426, , , , and .
CD40/CD154 interactions at the interface of tolerance and immunity. Ann Rev Immunol 2004, 22: 307–328, , and .
Heat shock proteins as ligands of Toll-like receptors. Cur Topics Microbiol Immunol 2002, 270: 169–184, and .
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation 1997, 64: 329–335, , , , , and .
Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999, 11: 1249–1255, and .
N. Consequences of cell death: exposure to necrotic tumour cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000, 191: 423–433, , , , and
Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur J Immunol 2002, 32: 155–162 and .
Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci USA 2000, 97: 14590–14595, and .
The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000, 191: 411–416, , and .
Tolerogenic dendritic cells. Ann Rev Immunol 2003, 21: 685–711, and .
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity. Trends Immunol 2002, 23: 445–449 and .
Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J Exp Med 2002, 195: 15–21, , , , , , , and .
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001, 193: 233–238, , , and .
On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity. J Exp Med 2002, 196: 217–227, , , , , and .
Uptake of apoptotic cells by lymphoid dendritic cells and cross-priming of CD8+ T cells produce active immune unresponsiveness. J Immunol 2002, 168: 5589–5595, , , , and .
Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions. Eur J Immunol 2001, 31: 959–965, , , , , , , and .
CD40 ligation abrogates the tolerogenic potential of lymphoid dendritic cells. J Immunol 2001, 166: 277–283, , , , , , , and .
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II. J Immunol 2004, 172: 202–213, , , , , , , and .
Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 2002, 99: 351–358 and .
A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci USA 1999, 96: 185–190.
Major differences in antigen-processing correlate with a single Arg71↔Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones. J Immunol 2002, 169: 3015–3020, , , and .
Mycobacterial heat-shock proteins as carrier molecules. Eur J Immunol 1991, 21: 2297–2302, , , , , , , and Del .
Mycobacterial heat-shock proteins as carrier molecules. II. The use of the 70kDa mycobacterial carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur J Immunol 1992, 22: 1365–1372, , , , , , , and Del .
Successful primate immunization with peptide conjugated to purified protein derrivative or mycobacterial heat shock proteins in the absence of adjuvants. Clin Exp Immunol 1993, 93: 382–386, , , , , , , , , and Del .
Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol 1996, 156: 873–879 and .
Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med 1993, 178: 1391–1396 and .
Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94. Proc Natl Acad Sci USA 1996, 93: 6135–6139, , , , and .
Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes. J Exp Med 1998, 187: 685–691, , , , , and .
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990, 347: 669–671, , and .
Human RANTES induces the migration of human T lymphocytes into the peripheral tissues of mice with severe combined immune deficiency. Eur J Immunol 1994, 24: 1823–1827, , , , , and .
Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 α, or human interleukin 8. J Exp Med 1993, 178: 1913–1921, , , , , , and .
CD8 positive influence antigen-specific immune responses through the expression of chemokines. J Clin Invest 1998, 102: 1112–1124, , , , , , , , , , , , , , and .
Human macrophage inflammatory protein alpha (MIP-1α) and MIP-1β chemokines attract distinct populations of lymphocytes. J Exp Med 1993, 177: 1821–1826, , , and .
Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998, 188: 373–386, , , , , , , , and .
Interleukin-12: a cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994, 84: 4008–4027.
Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG. Infect Immun 1988, 56: 1633–1640, , , , , , and .
Immunological study of defined constituents of mycobacteria. Springer Semin Immunopathol 1988, 10: 279–300, , and .
Innate immunity: impact on the adaptive immune response. Cur Opin Immunol 1997, 9: 4–9 and .
The instructive role of innate immunity in the acquired immune response. Science 1996, 272: 50–53 and .
Tolerance, danger, and the extended family. Ann Rev Immunol 1994, 12: 991–1045.
Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection. Nat Med 2001, 7: 732–737, , , , , , , , and .
A novel HIV-CCR5 receptor vaccine strategy in the control of mucosal SIV/HIV infection. AIDS 2004, 18: 25–36, , , , , , , , and .
Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol 1999, 27: 1627–1636, , , , , , , and .
The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J Immunol 2004, 172: 972–980, , , , and .
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med 2002, 196: 1403–1414, Teixeira , , , and .
The role of γδ T cells in generating antiviral factors and β-chemokines in protection against mucosal simian immunodeficiency virus infection. Eur J Immunol 2000, 30: 2245–2256, , , , , , , , and