Book contents
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap 1 OVERVIEW OF SOFT TISSUE TUMORS
- Chap 2 RADIOLOGIC EVALUATION OF SOFT TISSUE TUMORS
- Chap 3 IMMUNOHISTOCHEMISTRY OF SOFT TISSUE TUMORS
- Chap 4 GENETICS OF SOFT TISSUE TUMORS
- Chap 5 MOLECULAR GENETICS OF SOFT TISSUE TUMORS
- Chap 6 FIBROBLAST BIOLOGY, FASCIITIS, RETROPERITONEAL FIBROSIS, AND KELOIDS
- Chap 7 FIBROMAS AND BENIGN FIBROUS HISTIOCYTOMAS
- Chap 8 FIBROMATOSES
- Chap 9 BENIGN FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS IN CHILDREN
- Chap 10 CHILDHOOD FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS OF VARIABLE BIOLOGIC POTENTIAL
- Chap 11 MYXOMAS AND OSSIFYING FIBROMYXOID TUMOR
- Chap 12 SOLITARY FIBROUS TUMOR, HEMANGIOPERICYTOMA, AND RELATED TUMORS
- Chap 13 FIBROBLASTIC AND MYOFIBROBLASTIC NEOPLASMS WITH MALIGNANT POTENTIAL
- Chap 14 LIPOMA VARIANTS AND CONDITIONS SIMULATING LIPOMATOUS TUMORS
- Chap 15 ATYPICAL LIPOMATOUS TUMOR AND LIPOSARCOMAS
- Chap 16 SMOOTH MUSCLE TUMORS
- Chap 17 GASTROINTESTINAL STROMAL TUMOR
- Chap 18 STROMAL TUMORS AND TUMOR-LIKE LESIONS OF THE FEMALE GENITAL TRACT
- Chap 19 ANGIOMYOLIPOMA AND RELATED TUMORS (PERIVASCULAR EPITHELIOID CELL TUMORS)
- Chap 20 RHABDOMYOMAS AND RHABDOMYOSARCOMAS
- Chap 21 HEMANGIOMAS, LYMPHANGIOMAS, AND REACTIVE VASCULAR PROLIFERATIONS
- Chap 22 HEMANGIOENDOTHELIOMAS, ANGIOSARCOMAS, AND KAPOSI'S SARCOMA
- Chap 23 GLOMUS TUMOR, SINONASAL HEMANGIOPERICYTOMA, AND MYOPERICYTOMA
- Chap 24 NERVE SHEATH TUMORS
- Chap 25 NEUROECTODERMAL TUMORS: MELANOCYTIC, GLIAL, AND MENINGEAL NEOPLASMS
- Chap 26 PARAGANGLIOMAS
- Chap 27 PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION
- Chap 28 MALIGNANT MESOTHELIOMA AND OTHER MESOTHELIAL PROLIFERATIONS
- Chap 29 MERKEL CELL CARCINOMA AND METASTATIC AND SARCOMATOID CARCINOMAS INVOLVING SOFT TISSUE
- Chap 30 CARTILAGE- AND BONE-FORMING TUMORS AND TUMOR-LIKE LESIONS
- Chap 31 SMALL ROUND CELL TUMORS
- Chap 32 ALVEOLAR SOFT PART SARCOMA
- Chap 33 PATHOLOGY OF SYNOVIA AND TENDONS
- Chap 34 MISCELLANEOUS TUMOR-LIKE LESIONS, AND HISTIOCYTIC AND FOREIGN BODY REACTIONS
- Chap 35 LYMPHOID, MYELOID, HISTIOCYTIC, AND DENDRITIC CELL PROLIFERATIONS IN SOFT TISSUES
- Chap 36 CYTOLOGY OF SOFT TISSUE LESIONS
- Chap 37 SURGICAL MANAGEMENT OF SOFT TISSUE SARCOMA: HISTOLOGIC TYPE AND GRADE GUIDE SURGICAL PLANNING AND INTEGRATION OF MULTIMODALITY THERAPY
- Chap 38 MEDICAL ONCOLOGY OF SOFT TISSUE SARCOMAS
- Index
- References
Chap 27 - PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION
Published online by Cambridge University Press: 01 March 2011
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap 1 OVERVIEW OF SOFT TISSUE TUMORS
- Chap 2 RADIOLOGIC EVALUATION OF SOFT TISSUE TUMORS
- Chap 3 IMMUNOHISTOCHEMISTRY OF SOFT TISSUE TUMORS
- Chap 4 GENETICS OF SOFT TISSUE TUMORS
- Chap 5 MOLECULAR GENETICS OF SOFT TISSUE TUMORS
- Chap 6 FIBROBLAST BIOLOGY, FASCIITIS, RETROPERITONEAL FIBROSIS, AND KELOIDS
- Chap 7 FIBROMAS AND BENIGN FIBROUS HISTIOCYTOMAS
- Chap 8 FIBROMATOSES
- Chap 9 BENIGN FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS IN CHILDREN
- Chap 10 CHILDHOOD FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS OF VARIABLE BIOLOGIC POTENTIAL
- Chap 11 MYXOMAS AND OSSIFYING FIBROMYXOID TUMOR
- Chap 12 SOLITARY FIBROUS TUMOR, HEMANGIOPERICYTOMA, AND RELATED TUMORS
- Chap 13 FIBROBLASTIC AND MYOFIBROBLASTIC NEOPLASMS WITH MALIGNANT POTENTIAL
- Chap 14 LIPOMA VARIANTS AND CONDITIONS SIMULATING LIPOMATOUS TUMORS
- Chap 15 ATYPICAL LIPOMATOUS TUMOR AND LIPOSARCOMAS
- Chap 16 SMOOTH MUSCLE TUMORS
- Chap 17 GASTROINTESTINAL STROMAL TUMOR
- Chap 18 STROMAL TUMORS AND TUMOR-LIKE LESIONS OF THE FEMALE GENITAL TRACT
- Chap 19 ANGIOMYOLIPOMA AND RELATED TUMORS (PERIVASCULAR EPITHELIOID CELL TUMORS)
- Chap 20 RHABDOMYOMAS AND RHABDOMYOSARCOMAS
- Chap 21 HEMANGIOMAS, LYMPHANGIOMAS, AND REACTIVE VASCULAR PROLIFERATIONS
- Chap 22 HEMANGIOENDOTHELIOMAS, ANGIOSARCOMAS, AND KAPOSI'S SARCOMA
- Chap 23 GLOMUS TUMOR, SINONASAL HEMANGIOPERICYTOMA, AND MYOPERICYTOMA
- Chap 24 NERVE SHEATH TUMORS
- Chap 25 NEUROECTODERMAL TUMORS: MELANOCYTIC, GLIAL, AND MENINGEAL NEOPLASMS
- Chap 26 PARAGANGLIOMAS
- Chap 27 PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION
- Chap 28 MALIGNANT MESOTHELIOMA AND OTHER MESOTHELIAL PROLIFERATIONS
- Chap 29 MERKEL CELL CARCINOMA AND METASTATIC AND SARCOMATOID CARCINOMAS INVOLVING SOFT TISSUE
- Chap 30 CARTILAGE- AND BONE-FORMING TUMORS AND TUMOR-LIKE LESIONS
- Chap 31 SMALL ROUND CELL TUMORS
- Chap 32 ALVEOLAR SOFT PART SARCOMA
- Chap 33 PATHOLOGY OF SYNOVIA AND TENDONS
- Chap 34 MISCELLANEOUS TUMOR-LIKE LESIONS, AND HISTIOCYTIC AND FOREIGN BODY REACTIONS
- Chap 35 LYMPHOID, MYELOID, HISTIOCYTIC, AND DENDRITIC CELL PROLIFERATIONS IN SOFT TISSUES
- Chap 36 CYTOLOGY OF SOFT TISSUE LESIONS
- Chap 37 SURGICAL MANAGEMENT OF SOFT TISSUE SARCOMA: HISTOLOGIC TYPE AND GRADE GUIDE SURGICAL PLANNING AND INTEGRATION OF MULTIMODALITY THERAPY
- Chap 38 MEDICAL ONCOLOGY OF SOFT TISSUE SARCOMAS
- Index
- References
Summary
Epithelial differentiation is often easily detected histologically and is almost always highlighted with immunohistochemical markers (i.e., keratins, epithelial membrane antigen [EMA], and others). Mesothelial proliferations and tumors are discussed in Chapter 28, and Merkel cell carcinoma and metastatic carcinomas in Chapter 29.
Some other nonepithelial cells and tumors also can express keratins and other epithelial markers. Examples of normal varyingly keratin-positive mesenchymal cells include endothelial and smooth muscle cells and some myofibroblasts. Many nonepithelial tumors, such as melanomas and many sarcomas, occasionally are keratin positive. These are discussed in the appropriate chapters.
Synovial sarcoma and epithelioid sarcoma are epithelial tumors of soft tissue of unknown histogenesis. These tumors are not thought to be closely related.
Mixed tumors and related skin adnexal tumors, and chordoma, a tumor mimicking the features of notochord cells, are also reviewed here.
SYNOVIAL SARCOMA
A synovial sarcoma is a specific soft tissue sarcoma with dual epithelial and mesenchymal differentiation. The tumor is not related to synovial lining cells, and its association with synovia, if any, is only incidental. The name is based on historical reasons, because the epithelial component of the biphasic tumors was once thought to replicate synovial slits. The typical t(X;18) translocation with SS18-SSX gene fusion is a useful diagnostic marker.
Demographics of Synovial Sarcoma
Synovial sarcomas are relatively common sarcomas, constituting from 7% to 10% of all soft tissue sarcomas. This tumor typically presents in young adults, with a median age of approximately 30 years and a mild male predominance.
- Type
- Chapter
- Information
- Modern Soft Tissue PathologyTumors and Non-Neoplastic Conditions, pp. 777 - 810Publisher: Cambridge University PressPrint publication year: 2010
References
- 1
- Cited by