In the late-sixteenth century, a spate of violent incidents brought disrepute upon the mission enterprise in New Spain.Spanish churchmen lamented that some of their peers were inciting natives to disobey, resist, and even burn the churches of their ecclesiastical rivals.Spaniards spilled much ink in reporting these unseemly clashes in their correspondence and chronicles.Less reported are the many similar confrontations that occurred simultaneously in indigenous communities.Such was the worldly power of the mission enterprise that those Spanish churchmen and native rulers who did not have access to it jostled, often violently, to possess it.This chapter situates these curious episodes in the broader context of a series of political crises that shook the mendicant-indigenous mission enterprise to its very foundations in the 1570s and 1580s.It examines the politics of secularization, conflicts among indigenous jurisdictions for control of the mission Church, and the many points of cross-influence between Spanish and indigenous rivalries.As a result this chapter finds a mission enterprise that began to decline not solely due to Spanish political changes that undercut mendicant power, but rather because this weakening of mendicant power in the Spanish realm interacted with the on-going fragmentation and atomization of indigenous polities.