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2.04 - Loxapine

from First-Generation (Typical) Antipsychotics

Published online by Cambridge University Press:  19 October 2021

Edited by
Michael Cummings  and
Stephen Stahl
Michael Cummings
Affiliation:
University of California, Los Angeles
Stephen Stahl
Affiliation:
University of California, San Diego
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Summary

Typical or first-generation antipsychotic (FGA)

Type
Chapter
Information
Management of Complex Treatment-resistant Psychotic Disorders , pp. 117 - 120
Publisher: Cambridge University Press
Print publication year: 2021

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References

Meyer, J. M. (2018). Pharmacotherapy of psychosis and mania. In Brunton, L. L., Hilal-Dandan, R. and Knollmann, B. C. (eds.). Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th ed. Chicago, IL: McGraw-Hill, pp. 279–302.Google Scholar
Simpson, G. M., Cooper, T. B., Lee, J. H., et al. (1978). Clinical and plasma level characteristics of intramuscular and oral loxapine. Psychopharmacology (Berl), 56, 225–232.CrossRefGoogle ScholarPubMed
Kapur, S., Zipursky, R. B., Jones, C., et al. (1996). The D2 receptor occupancy profile of loxapine determined using PET. Neuropsychopharmacol, 15, 562–566.CrossRefGoogle ScholarPubMed
Kapur, S., Zipursky, R., Remington, G., et al. (1997). PET evidence that loxapine is an equipotent blocker of 5-HT2 and D2 receptors: implications for the therapeutics of schizophrenia. Am J Psychiatry, 154, 1525–1529.CrossRefGoogle ScholarPubMed
Alexza Pharmaceuticals Inc. (2011). Adasuve (loxapine) inhalation powder NDA 022549 – Psychopharmacologic Drug Advisory Committee briefing document, December 12, 2011. Food and Drug Administration.Google Scholar
Luo, J. P., Vashishtha, S. C., Hawes, E. M., et al. (2011). In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos, 32, 398–407.CrossRefGoogle ScholarPubMed
Galen US Inc. (2019). Adasuve Package Insert. Souderton, Pennsylvania.Google Scholar

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  • Loxapine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
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  • Loxapine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Loxapine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×