Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-75dct Total loading time: 0 Render date: 2024-06-04T16:36:08.939Z Has data issue: false hasContentIssue false

2.44 - Amitriptyline

from Tricyclic Antidepressants

Published online by Cambridge University Press:  19 October 2021

Michael Cummings
Affiliation:
University of California, Los Angeles
Stephen Stahl
Affiliation:
University of California, San Diego
Get access

Summary

Typical or first-generation antipsychotic (FGA)

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Trinkley, K. E., Nahata, M. C. (2014). Medication management of irritable bowel syndrome. Digestion, 89, 253267.CrossRefGoogle ScholarPubMed
Moore, R. A., Derry, S., Aldington, D., et al. (2015). Amitriptyline for neuropathic pain in adults. Cochrane Database Syst Rev, 2015, CD008242.Google ScholarPubMed
Scheiner, D. A., Perucchini, D., Fink, D., et al. (2015). Interstitial cystitis/bladder pain syndrome (IC/BPS). Praxis (Bern 1994), 104, 909918.CrossRefGoogle ScholarPubMed
Gillman, P. K. (2007). Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol, 151, 737748.CrossRefGoogle ScholarPubMed
Rheker, J., Rief, W., Doering, B. K., et al. (2018). Assessment of adverse events in clinical drug trials: identifying amitriptyline’s placebo- and baseline-controlled side effects. Exp Clin Psychopharmacol, 26, 320326.CrossRefGoogle ScholarPubMed
Perry, P. J., Zeilmann, C., Arndt, S. (1994). Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response. J Clin Psychopharmacol, 14, 230240.CrossRefGoogle ScholarPubMed
Brueckle, M. S., Thomas, E. T., Seide, S. E., et al. (2020). Adverse drug reactions associated with amitriptyline – protocol for a systematic multiple-indication review and meta-analysis. Syst Rev, 9, 59.CrossRefGoogle ScholarPubMed
Guy, S., Silke, B. (1990). The electrocardiogram as a tool for therapeutic monitoring: a critical analysis. J Clin Psychiatry, 51 Suppl. B, 3739.Google ScholarPubMed
Hicks, J. K., Sangkuhl, K., Swen, J. J., et al. (2017). Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther, 102, 3744.CrossRefGoogle ScholarPubMed
Lieberman, J. A., Cooper, T. B., Suckow, R. F., et al. (1985). Tricyclic antidepressant and metabolite levels in chronic renal failure. Clin Pharmacol Ther, 37, 301307.CrossRefGoogle ScholarPubMed
Gupta, S. K., Shah, J. C., Hwang, S. S. (1999). Pharmacokinetic and pharmacodynamic characterization of OROS and immediate-release amitriptyline. Br J Clin Pharmacol, 48, 7178.CrossRefGoogle ScholarPubMed
Hayasaka, Y., Purgato, M., Magni, L. R., et al. (2015). Dose equivalents of antidepressants: evidence-based recommendations from randomized controlled trials. J Affect Disord, 180, 179184.CrossRefGoogle ScholarPubMed
Constantino, J. L., Fonseca, V. A. (2019). Pharmacokinetics of antidepressants in patients undergoing hemodialysis: a narrative literature review. Braz J Psychiatry, 41, 441446.CrossRefGoogle ScholarPubMed
Cheng, Q., Huang, J., Xu, L., et al. (2020). Analysis of time-course, dose-effect, and influencing factors of antidepressants in the treatment of acute adult patients with major depression. Int J Neuropsychopharmacol, 23, 7687.CrossRefGoogle ScholarPubMed
Olesen, O. V., Linnet, K. (1997). Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes. Pharmacology, 55, 235243.CrossRefGoogle ScholarPubMed
Rasmussen, B. B., Nielsen, T. L., Brøsen, K. (1998). Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro. Eur J Clin Pharmacol, 54, 735740. doi: 710.1007/s002280050544CrossRefGoogle ScholarPubMed
Venkatakrishnan, K., Greenblatt, D. J., von Moltke, L. L., et al. (1998). Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol, 38, 112121.CrossRefGoogle ScholarPubMed
Patroneva, A., Connolly, S. M., Fatato, P., et al. (2008). An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects. Drug Metab Dispos, 36, 24842491.CrossRefGoogle ScholarPubMed
Undurraga, J., Baldessarini, R. J. (2017). Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-to-head trials in acute major depression: systematic review and meta-analysis. J Psychopharmacol, 31, 11841189.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Amitriptyline
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Amitriptyline
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Amitriptyline
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×