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33 - Lipid composition of brain microvessels

from Part IV - Signal transduction/biochemical aspects

Published online by Cambridge University Press:  10 December 2009

William M. Pardridge
Affiliation:
University of California, Los Angeles, School of Medicine
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Summary

Introduction

Membrane lipids containing fatty acids are important as they play a direct role in the structure and function of cells, including brain endothelial cells. Moreover, these latter cells transfer fatty acids from the blood to the brain cells. Brain is the second organ in terms of lipid content, after adipose tissue; in brain, lipids do not provide any energy, but play a structural role: they participate in the structure of membranes, and thus mediate their functions. This transfer is obligatory for essential fatty acids of dietary origin, but it is not yet known whether the essential linoleic (18:2(n-6)) and alphalinolenic (18:3(n-3)) acids are transferred, or whether it is the longer chains that are in fact transferred (mainly arachidonic acid, 20:4(n-6); and docosahexaenoic acid, 22:6(n-3), DHA).

Thus brain microvessel metabolism controls brain membrane polyunsaturated fatty acids. This is of special importance as, for instance, alterations in dietary (n-3) polyunsaturated fatty acids change the fatty acid profile of brain cell membranes (neurons, astrocytes and oligodendrocytes) and subcellular fractions (myelin and nerves endings) (Bourre et al., 1984), and thus alter brain structure and functions including learning performance. This has been documented in animal models (Bourre et al., 1989), and in human infants.

Type
Chapter
Information
Introduction to the Blood-Brain Barrier
Methodology, Biology and Pathology
, pp. 308 - 313
Publisher: Cambridge University Press
Print publication year: 1998

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