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  • Print publication year: 2009
  • Online publication date: July 2016

Section 1: - Interactions between the immune and nervous systems

References

Abbott NJ et al. Astrocyte–endothelial interactions at the blood–brain barrier. Nature Rev Immunol 2006; 7: 41–53.
Agostini L et al. NALP3 forms an IL-b-processing inflammasome with increased activity in Muckle–Wells autoinflammatory disorder. Immunity 2004; 20: 319–25.
Ahmed R, Gray D. Immunological memory and protective immunity: Understanding their relation. Science 1996; 272: 54–60.
Aloisi F. Immune function of microglia. Glia 2001; 36: 165–79.
Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nature Rev Immunol 2006; 6: 205–17.
Aloisi F, et al. Regulation of T cell responses by CNS antigen presenting cells: Different roles for microglia and astrocytes. Immunol Today 2000; 21: 141–7.
Alter A et al. Determinants of human B cell migration across brain endothelial cells. J Immunol 2003; 170: 4497–505.
Anthony IC, et al. B lymphocytes in the normal brain: Contrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain 2003; 126: 1058–67.
Babcock AA, et al. Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation. J Neurosci 2006; 26: 12826–37.
Baccalà R, et al. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nature Med 2007; 13: 543–51.
Bailey SL, et al. CNS myeloid DCs presenting endogenous myelin peptides ‘preferentially’ polarize CD4+ TH-17 cells in relapsing EAE. Nature Immunol 2007; 8: 172–80.
Baranzini SE, et al. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 1999; 163: 5133–44.
Bar-Or A, et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 2003; 126: 2738–49.
Bausinger H, et al. Endotoxin-free heat-shock protein 70 fails to induce APC activation. Eur J Immunol 2002; 32: 3708–13.
Bettelli E, et al. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest 2006; 116: 2393–402.
Bradbury MWB, Cole DF. The role of lymphatic system in drainage of cerebrospinal fluid and aqueous humor. J Physiol 1980; 299: 353–65.
Brambilla R, et al. Inhibition of astroglial nuclear factor kB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005; 202: 145–56.
Bsibsi M, et al. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 2002; 61: 1013–21.
Cepok S, et al. Identification of Epstein–Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 2005; 115: 1352–60.
Cogburn LA, Glick B. Lymphopoiesis in the chicken pineal gland. Am J Anat 1981; 162: 131–42.
Colombo M, et al. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol 2000; 164: 2782–9.
Columba-Cabezas S, et al. Suppression of established experimental autoimmune encephalomyelitis and formation of meningeal lymphoid follicles by lymphotoxin b receptor-Ig fusion protein. J Neuroimmunol 2006; 179: 76–86.
Creagh EM, O’Neill LAJ. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006; 27: 352–7.
Cserr HF, et al. Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 1992; 2: 269–76.
Derfuss T, et al. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 2001; 124: 1325–35.
De Vos AF, et al. Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol 2002; 169: 5415–23.
Ehlers M, Ravetch JV. Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance. Trends Immunol 2007; 28: 74–9.
Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms. Trends Immunol 2005; 26: 485–95.
Fabriek BO, et al. In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology. J Neuroimmunol 2005; 161: 190–4.
Farina C, et al. Preferential expression and function of Toll-like receptor 3 in human astrocytes. J Neuroimmunol 2005; 159: 12–19.
Farina C, et al. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007; 28: 138–45.
Fischer H-G, et al. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 2000; 164: 4826–34.
Fritz JH, et al. NOD-like proteins in immunity, inflammation and disease. Nature Immunol 2006; 7: 1250–7.
Genain CP, et al. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nature Med 1999; 5: 170–5.
Glezer I, et al. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J 2006; 20: 750–2.
Glynn P, et al. Analysis of immunoglobulin G in multiple sclerosis brain: Quantitative and isoelectric focusing studies. Clin Exp Immunol 1982; 48: 102–10.
Goverman J, et al. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 1993; 72: 551–60.
Greter M, et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nature Med 2005; 11: 328–34.
Hansen BS, et al. Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity. J Neuroimmunol 2006; 172: 94–103.
Hatterer E, et al. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 2006; 107: 806–12.
Haubold K, et al. B-lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluid. Ann Neurol 2004; 56: 97–107.
Hjelmström P. Lymphoid neogenesis: De novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J Leukocyte Biol 2001; 69: 331–9.
Hoffmann JA, et al. Phylogenetic perspectives in innate immunity. Science 1999; 284: 1313–8.
Iwamoto FM, DeAngelis LM. An update on primary central nervous system lymphoma. Hematol–Oncol Clin N Am 2006; 20: 1267.
Jack CS, et al. TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 2005; 175: 4320–30.
Kamradt T, et al. Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection. Trends Immunol 2005; 26: 260–7.
Kielian T. Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res 2006; 83: 711–30.
Kolln J, et al. Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol 2006; 177: 5652–8.
Krishnamoorthy G, et al. Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 2006; 116: 2385–92.
Krumbholz M, et al. BAF is produced by astrocytes and upregulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 2005; 201: 195–200.
Krumbholz M, et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006; 129: 200–11.
Lafon M, et al. The innate immune facet of brain – Human neurons express TLR-3 and sense viral dsRNA. J Mol Neurosci 2006; 29: 185–94.
Lambracht-Washington D, et al. Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS. J Neuroimmunol 2007; 186: 164–76.
Lassmann H, Wekerle H. The pathology of multiple sclerosis. In: Compston A, Confavreux C, Lassmann H, McDonald I, Miller D, Noseworthy J, et al., editors. McAlpine’s Multiple Sclerosis. Churchill Livingstone Elsevier, 2006: 557–600.
Lassmann H, et al. Bone-marrow derived elements and resident microglia in brain inflammation. Glia 1993; 7: 19–24.
Lee MS, Kim YJ. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 2007; 76: 447–80.
Lehnardt S, et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 2002; 22: 2478–86.
Lehnardt S, et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 2003; 100: 8514–9.
Liew FY, et al. Negative regulation of Toll-like receptor-mediated immune responses. Nature Rev Immunol 2005; 5: 446–58.
Linington C, et al. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 1988; 130: 443–54.
Litzenburger T, et al. B lymphocytes producing demyelinating autoantibodies: Development and function in gene-targeted transgenic mice. J Exp Med 1998; 188: 169–80.
Lucchinetti CF, et al. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of multiple sclerosis. Ann Neurol 2000; 47: 707–17.
Ma YH, et al. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 2006; 175: 209–15.
Magliozzi R, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007; 130: 1089–104.
Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nature Rev Immunol 2006; 6: 823–35.
McMahon EJ, et al. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nature Med 2005; 11: 335–9.
Medzhitov R. Toll-like receptors and innate immunity. Nature Rev Immunol 2001; 1: 135–45.
Medzhitov R, Janeway CA. Innate immunity: The virtues of a nonclonal system of recognition. Cell 1997; 91: 295–8.
Mehta PD, et al. Bound antibody in multiple sclerosis brains. J Neurol Sci 1981; 49: 91–8.
Mehta PD, et al. Oligoclonal IgG bands with and without measles antibody activity in sera of patients with subacute sclerosing panencephalitis. J Immunol 1982; 129: 1983–5.
Meier D, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity 2007; 26: 643–54.
Meinl E, et al. B lineage cells in the inflammatory CNS environment: Migration, maintenance, local antibody production and therapeutic modulation. Ann Neurol 2006; 59: 880–92.
Meylan E, et al. Intracellular pattern recognition receptors in the host response. Nature 2006; 442: 39–44.
Miller DH, et al. A controlled trial of Natalizumab for relapsing multiple sclerosis. N Engl J Med 2003; 348: 15–23.
Murray N, et al. Specificity of CSF antibodies against components of Borrelia burgdorferi in patients with meningopolyneuritis Garin–Bujadoux–Bannwarth. J Neurol 1986; 233: 224–7.
Neumann H, et al. Induction of MHC class I genes in neurons. Science 1995; 269: 549–52.
Neumann H, et al. Interferon-g gene expression in sensory neurons: Evidence for autocrine gene regulation. J Exp Med 1997a; 186: 2023–31.
Neumann H, et al. MHC class I gene expression in single neurons of the central nervous system: Differential regulation by interferon-g and tumor necrosis factor-a. J Exp Med 1997b; 185: 305–16.
Nguyen MD, et al. Innate immunity: The missing link in neuroprotection and neurodegeneration? Nature Rev Neurosci 2002; 3: 216–27.
O’Connor KC, et al. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol 2005; 175: 1974–82.
O’Connor KC, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Med 2007; 13: 211–7.
Owens GP, et al. Restricted use of VH4 germline segments in an acute multiple sclerosis brain. Ann Neurol 1998; 43: 236–43.
Park C, et al. TLR3-mediated signal induces pro-inflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. Glia 2006; 53: 248–56.
Paul S, et al. Type I interferon response in the central nervous system. Biochimie 2007; 89: 770–8.
Phillips MJ, et al. Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat. J Pathol 1997; 182: 457–64.
Piccio L, et al. Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: Critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J Immunol 2002; 168: 1940–9.
Piddlesden S, et al. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 1993; 143: 555–64.
Prineas JW. Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979; 203: 1123–5.
Prinz M, et al. Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest 2006; 116: 456–64.
Qin Y, et al. Clonal expansion and somatic hypermutation of VH genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998; 102: 1045–50.
Raivich G, et al. Lymphocyte infiltration in the injured brain: Role of pro-inflammatory cytokines. J Neurosci Res 2003; 72: 726–33.
Ransohoff RM. Microgliosis: The questions shape the answers. Nat Neurosci 2007; 10: 1507–9.
Ransohoff RM, Tani M. Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation? Trends Neurosci 1998; 21: 154–9.
Ransohoff RM, et al. Three or more routes for leukocyte migration into the central nervous system. Nature Rev Immunol 2003; 3: 569–81.
Ritchie AM, et al. Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol 2004; 173: 649–56.
Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav Immun 2003; 17: 13–9.
Ropper AH. Selective treatment of multiple sclerosis. N Engl J Med 2006; 354: 965–7.
Schluesener HJ, et al. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol 1987; 139: 4016–21.
Schnell L, et al. Lymphocyte recruitment following spinal cord injury in mice is altered by prior viral exposure. Eur J Neurosci 1997; 9: 1000–7.
Serafini B, et al. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am J Pathol 2000; 157: 1991–2002.
Serafini B, et al. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004; 14: 164–74.
Shukaliak JA, Dorovni-Zis K. CCL4 (MIP-1b)Expression of the b-chemokines RANTES and MIP-1b by human brain microvessel endothelial cells in primary culture. J Neuropathol Exp Neurol 2000; 59: 339–52.
Sriram S, et al. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol 1999; 46: 6–14.
Tahara K, et al. Role of toll-like receptor signaling in Ab uptake and clearance. Brain 2006; 129: 3006–19.
Uccelli A, et al. Unveiling the enigma of the CNS as a B-cell fostering environment. Trends Immunol 2006; 26: 254–9.
van Loo G, et al. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol 2006a; 7: 954–61.
van Loo G, et al. Inhibition of transcription factor NF-kB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nature Immunol 2006b; 7: 954–61.
Visser L, et al. Pro-inflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease. J Immunol 2005; 174: 808–16.
Visser L, et al. Phagocytes containing a disease-promoting Toll-like receptor/NOD ligand are present in the brain during demyelinating disease in primates. Am J Pathol 2006; 169: 1671–85.
Wagner H. Endogenous TLR ligands and autoimmunity. Adv Immunol 2006; 91: 159–73.
Waldner H, et al. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest 2004; 113: 990–7.
Ware CF. Network communications: Lymphotoxins, LIGHT and TNF. Annu Rev Immunol 2005; 23: 787–819.
Wekerle H. Antigen presentation by CNS glia. In: Kettenmann H, Ransom B, (Eds). Neuroglial Cells. Oxford, UK: Oxford University Press, 1994.
Wekerle H. Breaking ignorance: The case of the brain. In: Radbruch A, Lipsky PE, (Eds). Current Concepts in Autoimmunity and Chronic Inflammation. Berlin: Springer, 2006: 25–50.
Wekerle H, et al. Cellular immune reactivity within the CNS. Trends Neurosci 1986; 9: 271–7.
Wolf NA, et al. Synergistic interaction between Toll-like receptor agonists is required for induction of experimental autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2007; 185: 115–22.
Wong D, Dorovini-Zis K. Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary culture of human brain microvessel endothelial cells by cytokines and lipopolysaccharide. J Neuroimmunol 1992; 39: 11–22.
Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease – A double-edged sword. Neuron 2002; 35: 419–32.
Zekki H, et al. The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol 2002; 12: 308–19.

References

Ajami B et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007; 10: 1538–43.
Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001; 2: 734–44.
Allan SM, et al. Interleukin-1 and neuronal injury. Nat Rev Immunol 2005; 5: 629–40.
Amin AR, et al. A novel mechanism of action of tetracyclines: Effects on nitric oxide synthase. Proc Natl Acad Sci USA 1996; 93: 14014–19.
Arai H, et al. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1β and expression of caspase-11 in mice. J Biol Chem 2003; 279: 51647–53.
Babior BM. NADPH oxidase. Curr Opin Immunol 2004; 16: 42–7.
Banati RB. Neuropathological imaging: In vivo detection of glial activation as a measure of disease and adaptive change in the brain. Brit Med Bull 2003; 65: 121–31.
Banno M, et al. The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia. Neuropharmacology 2005; 48: 283–90.
Byrnes KR, et al. Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Glia 2006; 53: 420–33.
Cardona AE, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nature Neurosci 2006; 9: 917–24.
Chamak B, et al. Immunohistochemical detection of thrombospondin in microglia in the developing rat brain. Neuroscience 1995; 69: 177–87.
Chao CC, et al. Neuroprotective role of IL-4 against activated microglia. J Immunol 1993; 151: 1473–81.
Chao CC, et al. Modulation of human microglial cell superoxide production by cytokines. J Leukoc Biol 1995; 58: 65–70.
Choi SH, et al. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. J Neurosci 2003; 23: 5877–86.
Craner MJ, et al. Sodium channels contribute to microglia/macrophage activation and function in EAE and MS. Glia 2005; 49: 220–9.
Davalos D, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005; 8: 752–8.
Dougherty KD, et al. Brain-derived neurotrophic factor in astrocytes, oligodendrocytes and microglia/macrophages after spinal cord injury. Neurobiol Dis 2000; 7: 574–85.
Duffield JS. The inflammatory macrophage: A story of Jekyll and Hyde. Clin Sci 2003; 104: 27–38.
Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multi-centers. Cerebrovasc Dis 2003; 15: 222–9.
Eder C. Regulation of microglial behavior by ion channel activity. J Neurosci Res 2005; 81: 314–21.
Eljaschewitsch E, et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 2006; 49: 67–79.
Elkabes S, et al. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 1 1996; 6: 2508–21.
Elkabes S, et al. Lipopolysaccharide differentially regulates microglial Trk receptor and neurotrophin expression. J Neurosci Res 1998; 54: 117–22.
Festoff BW, et al. Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. J Neurochem 2006; 97: 1314–26.
Flanary BE, Streit WJ. Alpha-tocopherol (vitamin E) induces rapid, nonsustained proliferation in cultured rat microglia. Glia 2006; 53: 669–74.
Fordyce CB, et al. Microglia Kv1.3 channels contribute to their ability to kill neurons. J Neurosci 2005; 25: 7139–49.
Friedman WJ, et al. Distribution of the neurotrophins, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical study. Neuroscience 1998; 84: 101–14.
Gingrich MB, Traynelis SF. Serine proteases and brain damage: Is there a link? Trends Neurosci 2000; 23: 399–407.
Gregersen R, et al. Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J Cerebr Blood Flow Metab 2000; 20: 53–65.
Hallenbeck JM. The many faces of tumor necrosis factor in stroke. Nature Med 2002; 8: 1363–8.
Hatori K, et al. Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 2002; 69: 418–26.
Haynes SE, et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 2006; 9: 1512–19.
Hirasawa T, et al. Visualization of microglia in living tissues using Iba1-EGFP transgenic mice. J Neurosci Res 2005; 81: 357–62.
Hirrlinger J, et al. Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species. Dev Neurosci 2000; 22: 384–92.
Inoue K. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol Ther 2006; 109: 210–26.
Johnston IN, et al. A role for pro-inflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci 2004; 24: 9353–65.
Kamata H, et al. Reactive oxygen species promote TNF-α-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649–61.
Katsuki H, et al. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. J Neurochem 2006; 97: 1232–42.
Kempermann G, Neumann H. Microglia: The enemy within? Science 2003; 302: 1689–90.
Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res 2005; 81: 302–13.
Kinsner A, et al. Highly purified lipoteichoic acid induced pro-inflammatory signaling in primary culture of rat microglia through toll-like receptor 2: Selective potentiation of nitric oxide production by muramyl dipeptide. J Neurochem 2006; 99: 596–607.
Kong GY, et al. Inducible nitric oxide synthase expression elicited in the mouse brain by inflammatory mediators circulating in the cerebrospinal fluid. Brain Res 2000; 878: 105–18.
Kraus RL, et al. Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem 2005; 94: 819–27.
Kreutzberg GW. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 1996; 19: 312–18.
Lawson LJ, et al. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990; 39: 151–70.
Li J, et al. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci USA 2005; 102: 9936–41.
Lu DY, et al. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1α. Biochem Pharmacol 2006; 72: 992–1000.
Mander P, Brown GC. Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: A dual-key mechanism of inflammatory neurodegeneration. J Neuroinflam 2005; 2: 20–34.
Mander P, et al. Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase. J Immunol 2006; 176: 1046–52.
Marchetti B, et al. Glia–neuron crosstalk in neuroinflammation, neurodegeneration and neuroprotection. Brain Res Brain Res Rev 2005; 48: 129–408.
Marin-Teva JL, et al. Microglia promote the death of developing Purkinje cells. Neuron 2004; 41: 535–47.
Minghetti L, et al. Microglial activation in chronic neurodegenerative diseases: Roles of apoptotic neurons and chronic stimulation. Brain Res Brain Res Rev 2005; 48: 251–6.
Nakajima K, Kohsaka S. Microglia: neuroprotective and neurotrophic cells in the central nervous system. Curr Drug Targets Cardiovasc Hematol Disord 2004; 4: 65–84.
Nimmerjahn A, et al. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314–18.
Noda M, et al. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J Neurosci 2000; 20: 251–8.
Noorbakhsh F, et al. Proteinase-activated receptors in the nervous system. Nat Rev Neurosci 2003; 4: 981–90.
Persson M, et al. Lipopolysaccharide increases microglial GLT-1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF-α. Glia 2005; 51: 111–20.
Pinteaux E, et al. Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J Neurochem 2002; 83: 754–63.
Raivich G, et al. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function. Brain Res Rev 1999; 30: 77–105.
Rappert A, et al. CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci 2004; 24: 8500–9.
DB, Przedborski S. Fractalkine: moving from chemotaxis to neuroprotection. Nature Neurosci 2006; 9: 859–61.
Robinson AP, et al., Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology 1986; 57: 239–47.
Roulston CL, et al. Non-angiotensin II [125I]-CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: Comparison with markers for activated microglia. Neuroscience 2004; 127: 753–67.
Sargsyan SA, et al. Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis. Glia 2005; 51: 241–53.
Sriram K, et al. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-α. FASEB J 2006; 20: 670–82.
Staykova MA, et al. Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis. Am J Pathol 2005; 166: 147–57.
Stoll G, Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 1999; 58: 233–47.
Streit WJ. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 2002; 40: 133–9.
Streit WJ, et al. Reactive microgliosis. Prog Neurobiol 1999; 57: 563–81.
Suk K. Minocycline suppresses hypoxic activation of rodent microglia in culture. Neurosci Lett 2004; 366: 167–71.
Suo Z, et al. Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation. J Biol Chem 2003; 278: 3177–83.
Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984; 53: 749–90.
Takano K, et al. Microglial cell death induced by a low concentration of polyamines. Neuroscience 2003; 120: 961–7.
Takano K, et al. Oxidative metabolites are involved in polyamine-induced microglial cell death. Neuroscience 2005; 134: 1123–31.
Takayama N, Ueda H. Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia. J Neurosci 2005; 25: 430–5.
Takeuchi H, et al. Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 2006; 281: 21362–8.
Taylor DL, et al. Stimulaton of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial-derived fas ligand. J Neurosci 2005; 25: 2952–64.
Ubogu EE, et al. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 2006; 27: 48–54.
Vilhardt F. Microglia: Phagocyte and glia cell. Int J Biochem Cell Biol 2005; 37: 17–21.
Weinstein JR, et al. Cellular localization of thrombin receptor mRNA in rat brain: Expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J Neurosci 1995; 15: 2506–19.
Wilkinson BL, Landreth GE. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer’s disease. J Neuroinflamm 2006; 3: 30–42.
Witting A, et al. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc Natl Acad Sci USA 2004; 101: 3214–19.
Zhao W, et al. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motorneuron toxicity induced by activated microglia. J Neurochem 2006; 99: 1176–87.

References

Abreu-Silva AL, et al. Central nervous system involvement in experimental infection with Leishmania (Leishmania) amazonensis. Am J Trop Med Hyg 2003; 68: 661–5.
Bailey SL, et al. CNS myeloid DCs presenting endogenous myelin peptides ‘preferentially’ polarize CD4+ T(H)-17 cells in relapsing EAE. Nature Immunol 2007; 8: 172–80.
Bonasio R, et al. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nature Immunol 2006; 7: 1092–100.
Carson MJ, et al. Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells. Am J Pathol 1999; 154: 481–94.
Caux C, et al. GM-CSF and TNFα cooperate in the generation of dendritic Langerhans cells. Nature 1992; 360: 258.
Chen H, et al. Comparisons of HIV-1 viral sequences in brain, choroid plexus and spleen: Potential role of choroid plexus in the pathogenesis of HIV encephalitis. J Neurovirol 2000; 6: 498–506.
Cserr HF, et al. Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 1992; 2: 269–76.
Curtin JF, et al. Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. J Immunol 2006; 176: 3566–77.
Deshpande P, et al. Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease process. J Immunol 2007; 178: 6695–9.
Donaghy H, et al. HIV interactions with dendritic cells: Has our focus been too narrow? J Leukoc Biol 2006; 80: 1001–12.
Fischer HG, Bielinsky AK. Antigen presentation function of brain-derived dendriform cells depends on astrocyte help. Int Immunol 1999; 11: 1265–74.
Fischer HG, Reichmann G. Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J Immunol 2001; 166: 2717–26.
Fischer HG, et al. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 2000; 164: 4826–34.
Greter M, et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nature Med 2005; 11: 328–34.
Grouard G, et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185: 1101.
Hanly A, Petito CK. HLA-DR-positive dendritic cells of the normal human choroid plexus: A potential reservoir of HIV in the central nervous system. Hum Pathol 1998; 29: 88–93.
Hatterer E, et al. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 2006; 107: 806–12.
Henkel JS, et al. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 2004; 55: 221–35.
Karman J, et al. Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 2004; 173: 2353–61.
Kivisakk P, et al. Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci USA 2003; 100: 8389–94.
Kivisakk P, et al. Expression of CCR7 in multiple sclerosis: Implications for CNS immunity. Ann Neurol 2004; 55: 627–38.
Lauterbach H, et al. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med 2006; 203: 1963–75.
Matyszak MK, Perry VH. The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system. Neuroscience 1996; 74: 599–608.
McMahon EJ, et al. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nature Med 2005; 11: 335–9.
McMahon EJ, et al. CNS dendritic cells: Critical participants in CNS inflammation? Neurochem Int Mol Mech Neuroinflam 2006; 49: 195–203.
McMenamin PG. Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. J Comp Neurol 1999; 405: 553–62.
Newman TA, et al. Blood-derived dendritic cells in an acute brain injury. J Neuroimmunol 2005; 166: 167–72.
Pashenkov M, et al. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 2001; 124: 480–92.
Pashenkov M, et al. Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis. Clin Exp Immunol 2002a; 127: 519–26.
Pashenkov M, et al. Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections. J Neuroimmunol 2002b; 122: 106–16.
Plumb J, et al. CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions. Mult Scler 2003; 9: 142–7.
Press R, et al. Dendritic cells in the cerebrospinal fluid and peripheral nerves in Guillain–Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 2005; 159: 165–76.
Pulendran B, et al. Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo. J Immunol 2000; 165: 566–72.
Reichmann G, et al. Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J Neuroimmunol 2002; 129: 125–32.
Rissoan MC, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183–6.
Robinson SP, et al. Human peripheral blood contains two distinct lineages of dendritic cells. Eur J Immunol 1999; 29: 2769–78.
Romani N, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994; 180: 83–93.
Rosicarelli B, et al. Migration of dendritic cells into the brain in a mouse model of prion disease. J Neuroimmunol 2005; 165: 114–20.
Sato T, Inoue K. Dendritic cells in the rat pituitary gland evaluated by the use of monoclonal antibodies and electron microscopy. Arch Histol Cytol 2000; 63: 291–303.
Serafini B, et al. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am J Pathol 2000; 157: 1991–2002.
Serafini B, et al. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004; 14: 164–74.
Serbina NV, et al. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 2003; 19: 59–70.
Serot JM, et al. Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium. Neuroreport 1997; 8: 1995–8.
Serot JM, et al. Monocyte-derived IL-10-secreting dendritic cells in choroid plexus epithelium. J Neuroimmunol 2000; 105: 115–19.
Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nature Rev Immunol 2002; 2: 151–61.
Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nature Rev Immunol 2007; 7: 19–30.
Siegal FP, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999; 284: 1835–7.
Suter T, et al. Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis. Eur J Immunol 2000; 30: 794–802.
Suter T, et al. The brain as an immune privileged site: Dendritic cells of the central nervous system inhibit T cell activation. Eur J Immunol 2003; 33: 2998–3006.
Turville SG, et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 2002; 3: 975–83.
Villadangos JA, Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nature Rev Immunol 2007; 7: 543–55.
Witmer-Pack MD, et al. Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145: II. Expression in situ in lymphoid and nonlymphoid tissues. Cell Immunol 1995; 163: 157–62.
Zozulya AL, et al. Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1{alpha} chemokine and matrix metalloproteinases. J Immunol 2007; 178: 520–9.

References

Abbott NJ, et al. Astrocyte–endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 2006; 7: 41–53.
Adamson P, et al. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. J Immunol 1999; 162: 2964–73.
Allt G, Lawrenson JG. Is the pial microvessel a good model for blood–brain barrier studies? Brain Res Brain Res Rev 1997; 24: 67–76.
Alt C, et al. Functional expression of the lymphoid chemokines CCL19 (ELClc) and CCL21 (SLC) at the blood–brain barrier suggests their possible involvement in lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol 2002; 32: 2133–44.
Andras IE, et al. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 2005; 25: 1159–70.
Archelos JJ, et al. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann Neurol 1993; 34: 145–54.
Banks WA, et al. The blood–brain barrier in neuroaids. Curr HIV Res 2006; 4: 259–66.
Barragan A, Sibley LD. Migration of Toxoplasma gondii across biological barriers. Trends Microbiol 2003; 11: 426–30.
Barragan A, et al. Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol 2005; 7: 561–8.
Barreiro O, et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol 2002; 157: 1233–45.
Battistini L, et al. Cd8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: A critical role for P-selectin glycoprotein ligand-1. Blood 2003; 101: 4775–82.
Betz LA, et al. Blood brain–cerebrospinal fluid barriers. In Siegel GJ (Ed.), Basic Neurochemistry: Molecular, Cellular, And Medical Aspects. New York: Raven Press.
Bo L, et al. Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions. J Neuropathol Exp Neurol 1996; 55: 1060–72.
Bouchaud C, Bosler O. The circumventricular organs of the mammalian brain with special reference to monoaminergic innervation. Int Rev Cytol 1986; 105: 283–327.
Brocke S, et al. Antibodies to Cd44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci USA 1999; 96: 6896–901.
Bullard DC, et al. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J Immunol 2007; 178: 851–7.
Butcher EC, et al. Lymphocyte trafficking and regional immunity. Adv Immunol 1999; 72: 209–53.
Cannella B, et al. Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis. J Neuroimmunol 1993; 46: 43–55.
Carlos TM, Harlan JM. Leukocyte–endothelial adhesion molecules. Blood 1994; 7: 2068–101.
Carman CV, Springer TA. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol 2004; 167: 377–88.
Carrithers MD, et al. Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. Brain 2000; 123: 1092–101.
Carrithers MD, et al. Role of genetic background in P Selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 2002; 129: 51–7.
Carvalho-Tavares J, et al. A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ Res 2000; 87: 1141–8.
Cattelino A, et al. The conditional inactivation of the {beta}-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 2003; 162: 1111–22.
Columba-Cabezas S, et al. Lymphoid chemokines CCL19 And CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: Implications for the maintenance of chronic neuroinflammation. Brain Pathol 2003; 13: 38–51.
Courret N, et al. Cd11c- and Cd11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Blood 2006; 107: 309–16.
Crone C, Olesen SP. Electrical resistance of brain microvascular endothelium. Brain Res 1982; 241: 49–55.
Cross AH, Raine CS. Central nervous system endothelial cell–polymorphonuclear cell interactions during autoimmune demyelination. Am J Pathol 1991; 139: 1401–9.
Deckert Schluter M, et al. Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, MAC-1, CD43, VLA-4, and MHC class II antigens in murine toxoplasma encephalitis: A light microscopic and ultrastructural immunohistochemical study. J Neuropathol Exp Neurol 1994; 53: 457–68.
Del Maschio A, et al. Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM). J Exp Med 1999; 190: 1351–6.
Doulet N, et al. Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures. J Cell Biol 2006; 173: 627–37.
Dzenko KA, et al. The chemokine receptor Ccr2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. J Neurosci 2001; 21: 9214–23.
Dziegielewska KM, et al. Development of the choroid plexus. Microsc Res Tech 2001; 52: 5–20.
Ebnet K, et al. Junctional adhesion molecules (JAMs): More molecules with dual functions? J Cell Sci 2004; 117: 19–29.
Engelhardt B. Development of the blood–brain barrier. Cell Tissue Res 2003; 314: 119–29.
Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms. Trends Immunol 2005; 26: 485–95.
Engelhardt B, Wolburg H. Mini-review: Transendothelial migration of leukocytes – Through the front door or around the side of the house? Eur J Immunol 2004; 34: 2955–63.
Engelhardt B, et al. Lymphocytes infiltrating the CNS during inflammation display a distinctive phenotype and bind to VCAM-1 but not to MADCAM-1. Int Immunol 1995; 7: 481–91.
Engelhardt B, et al. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood–brain barrier in experimental autoimmune encephalomyelitis. Blood 1997; 90: 4459–72.
Engelhardt B, et al. The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J Clin Invest 1998a; 102: 2096–105.
Engelhardt B, et al. Adhesion molecule phenotype of T lymphocytes in inflamed CNS. J Neuroimmunol 1998b; 84: 92–104.
Engelhardt B, et al. Involvement of the choroid plexus in central nervous system inflammation. Microsc Res Tech 2001; 52: 112–29.
Engelhardt B, et al. PSGL-1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57bl6 mice. J Immunol 2005; 175: 1267–75.
Graesser D, et al. Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest 2002; 109: 383–92.
Greenwood J, et al. Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol 2003; 171: 2099–108.
Grewal IS, et al. Cd62l is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis. Immunity 2001; 14: 291–302.
Hickey WF, et al. T-lymphocyte entry into the central nervous system. J Neurosci Res 1991; 28: 254–60.
Huang S, Jong AY. Cellular mechanisms of microbial proteins contributing to invasion of the blood–brain barrier. Cell Microbiol 2001; 3: 277–87.
Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J 2003; 7: 678–86.
Johnson-Léger C, Imhof BA. Forging the endothelium during inflammation: Pushing at a half-open door? Cell Tiss Res 2003; 314: 93–105.
Kanmogne GD, et al. HIV-1 Gp120 compromises blood–brain barrier integrity and enhances monocyte migration across blood–brain barrier: Implication for viral neuropathogenesis. J Cereb Blood Flow Metab 2007; 27: 123–34.
Kent SJ, et al. A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol 1995; 58: 1–10.
Kerfoot S, Kubes P. Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J. Immunol 2002; 169: 1000–6.
Kim KS. Microbial translocation of the blood–brain barrier. Int J Parasitol 2006; 36: 607–14.
Kivisakk P, et al. Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci USA 2005; 100: 8389–94. Epub 2003 Jun 26.
Kleine TO, Benes L. Immune surveillance of the human central nervous system (CNS): Different migration pathways of immune cells through the blood–brain barrier and blood–cerebrospinal fluid barrier in healthy persons. Cytometry A 2006; 69: 147–51.
Laschinger M, Engelhardt, B. Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro. J Neuroimmunol 2000; 102: 32–43.
Laschinger M, et al. Encephalitogenic T cells use LFA-1 during transendothelial migration but not during capture and adhesion in spinal cord microvessels in vivo. Eur J Immunol 2002; 32: 3598–606.
Lechner F, et al. Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection. J Infect Dis 2000; 182: 978–82.
Leonhardt H. Ependym und Circumventriculäre Organe. In Oksche A, Vollrath L (Eds.), Handbuch der Mikroskopischen Anatomie des Menschen. Berlin/Heidelberg/New York: Springer, 1980a.
Leonhardt H. Ependym und Zirkumventrikuläre Organe. Berlin: Springer, 1980b.
Luster AD, et al. Immune cell migration in inflammation: Present and future therapeutic targets. Nat Immunol 2005; 6: 1182–90.
Lyck R, et al. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 2003; 102: 3675–83.
Maclean AG, et al. Activation of the blood–brain barrier by SIV (simian immunodeficiency virus) requires cell-associated virus and is not restricted to endothelial cell activation. Biochem Soc Trans 2004; 32: 750–2.
Martin R, Mcfarland HF. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit Rev Clin Lab Sci 1995; 32: 121–82.
Martin-Padura I, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998; 142: 117–27.
Millan J, et al. Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol 2006; 8: 113–23. Epub 2006 Jan 22.
Muller WA. Leukocyte–endothelial cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 2003; 6: 327–34.
Nasdala I, et al. A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem 2002; 277: 16294–303.
Osmers I, et al. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J Neuroimmunol 2005; 166: 193–6.
Padden M, et al. differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: Increasing evidence for the role of tight junction pathology. Acta Neuropathol (Berl) 2007; 113: 177–86. Epub 2006 Oct 6.
Pardridge WM. Blood–brain barrier delivery. Drug Discov Today 2007; 12: 54–61.
Phillipson M, et al. Intraluminal crawling of neutrophils to emigration sites: A molecularly distinct process from adhesion in the recruitment cascade. J Exp Med 2006; 203: 2569–75.
Piccio L, et al. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. J Immunol 2005; 174: 5805–13.
Piccio L, et al. Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: Critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(I)-linked receptors. J Immunol 2002; 168: 1940–9.
Plumb J, et al. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol 2002; 12: 154–69.
Polman CH, et al. A randomized, placebo-controlled trial of Natalizumab for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899–910.
Qing Z, et al. Inhibition of antigen-specific T cell trafficking into the central nervous system via blocking PECAM1/CD31 molecule. J Neuropathol Exp Neurol 2001; 60: 798–807.
Rascher G, Wolburg H. The tight junctions of the leptomeningeal blood–cerebrospinal fluid barrier during development. J Hirnforsch 1997; 38: 525–40.
Reiss Y, et al. T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur J Immunol 1998; 28: 3086–99.
Ring A, et al. Pneumococcal trafficking across the blood–brain barrier. Molecular analysis of a novel bidirectional pathway. J Clin Invest 1998; 102: 347–60.
Risau W, et al. Immune function of the blood–brain barrier: Incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J Cell Biol 1990; 110: 1757–66.
Rudick RA, et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 2006; 354: 911–23.
Schluter D, et al. Immune reactions to Listeria monocytogenes in the brain. Immunobiology 1999; 201: 188–95.
Schulz M, Engelhardt B. The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis. Cerebrospinal Fluid Res 2005; 2: 8.
Schulze C, Firth JA. Immunohistochemical localization of adherens junction components in blood–brain barrier microvessels of the rat. JCell Sci 1993; 104: 773–82.
Sedgwick JD, et al. Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4+ T cell lines in vitro. J Immunol 1990; 145: 2474–81.
Sixt M, et al. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood–brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol 2001; 153: 933–46.
Sobel RA, et al. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 1990; 136: 1309–16.
Steffen BJ, et al. ICAM-1, VCAM-1, and MADCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol 1996; 148: 1819–38.
Steffen BJ, et al. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol 1994; 145: 189–201.
Ubogu EE, et al. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 2006; 27: 48–55.
Vajkoczy P, et al. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest 2001; 108: 557–65.
Wekerle H, et al. Cellular immune reactivity within the CNS. TINS 1986; 9: 271–7.
Welsh CT, et al. Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1a. J Neuroimmunol 1993; 43: 161–8.
Willenborg DO, et al. ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system. J Neuroimmunol 1993; 45: 147–54.
Wolburg H, Lippoldt A. Tight junctions of the blood–brain barrier. Development, composition and regulation. Vasc Pharmacol 2002; 28: 323–37.
Wolburg H, et al. Localization of claudin-3 in tight junctions of the blood–brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol (Berl) 2003; 105: 586–92.
Wolburg H, et al. Osp/claudin-11, claudin-1 and claudin-2 are present in tight junctions of choroid plexus epithelium of the mouse. Neurosci Lett 2001; 13: 77–80.
Yednock TA, et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992; 356: 63–6.
Yousry TA, et al. Evaluation of patients treated with Natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 2006; 354: 924–33.
Zeine R, Owens T. Direct demonstration of the infiltration of murine central nervous system by PGP-1/Cd44 high Cd45rblow Cd4+ T cells that induce experimental allergic encephalomyelitis. J Neuroimmunol 1992; 40: 57–70.