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Chapter 41 - Hematopoietic Cell Transplants for Indolent Lymphomas

from Section 12 - Hematopoietic Cell Transplants for Lymphomas: Changing Indications

Published online by Cambridge University Press:  24 May 2017

Hillard M. Lazarus
Affiliation:
Case Western Reserve University, Ohio
Robert Peter Gale
Affiliation:
Imperial College London
Armand Keating
Affiliation:
University of Toronto
Andrea Bacigalupo
Affiliation:
Ospedale San Martino, Genoa
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Kerry Atkinson
Affiliation:
University of Queensland
Syed Ali Abutalib
Affiliation:
Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
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Hematopoietic Cell Transplants
Concepts, Controversies and Future Directions
, pp. 392 - 401
Publisher: Cambridge University Press
Print publication year: 2000

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References

Marcus, R, Imrie, K, Solal-Celigny, P, Catalano, JV, Dmoszynska, A, Raposo, JC, et al. Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol. 2008;26(28):4579–86.CrossRefGoogle ScholarPubMed
Hiddemann, W, Kneba, M, Dreyling, M, Schmitz, N, Lengfelder, E, Schmits, R, et al. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2005;106(12):3725−32.CrossRefGoogle Scholar
Forstpointner, R, Dreyling, M, Repp, R, Hermann, S, Hanel, A, Metzner, B, et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2004;104(10):3064–71.CrossRefGoogle ScholarPubMed
van Oers, MH, Klasa, R, Marcus, RE, Wolf, M, Kimby, E, Gascoyne, RD, et al. Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial. Blood. 2006;108(10):3295−301.CrossRefGoogle ScholarPubMed
Salles, G, Seymour, JF, Offner, F, Lopez-Guillermo, A, Belada, D, Xerri, L, et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet. 2011;377(9759):4251.CrossRefGoogle Scholar
Morschhauser, F, Radford, J, Van Hoof, A, Vitolo, U, Soubeyran, P, Tilly, H, et al. Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after first remission in advanced follicular lymphoma. J Clin Oncol. 2008;26(32):5156–64.CrossRefGoogle ScholarPubMed
Rummel, MJ, Niederle, N, Maschmeyer, G, Banat, GA, von Grunhagen, U, Losem, C, et al. Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013;381(9873):1203−10.CrossRefGoogle ScholarPubMed
Flinn, IW, van der Jagt, R, Kahl, BS, Wood, P, Hawkins, TE, Macdonald, D, et al. Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood. 2014;123(19):2944–52.CrossRefGoogle ScholarPubMed
Federico, M, Luminari, S, Dondi, A, Tucci, A, Vitolo, U, Rigacci, L, et al. R-CVP versus R-CHOP versus R-FM for the initial treatment of patients with advanced-stage follicular lymphoma: results of the FOLL05 trial conducted by the Fondazione Italiana Linfomi. J Clin Oncol. 2013;31(12):1506−13.CrossRefGoogle ScholarPubMed
Lenz, G, Dreyling, M, Schiegnitz, E, Forstpointner, R, Wandt, H, Freund, M, et al. Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group. Blood. 2004;104(9):2667–74.CrossRefGoogle ScholarPubMed
Deconinck, E, Foussard, C, Milpied, N, Bertrand, P, Michenet, P, Cornillet-LeFebvre, P, et al. High-dose therapy followed by autologous purged stem-cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by GOELAMS. Blood. 2005;105(10):3817−23.CrossRefGoogle ScholarPubMed
Sebban, C, Mounier, N, Brousse, N, Belanger, C, Brice, P, Haioun, C, et al. Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d’Etude des Lymphomes de l’Adulte (GELA). Blood. 2006;108(8):2540–4.CrossRefGoogle ScholarPubMed
Al Khabori, M, de Almeida, JR, Guyatt, GH, Kuruvilla, J, Crump, M. Autologous stem cell transplantation in follicular lymphoma: a systematic review and meta-analysis. J Natl Cancer Inst. 2012;104(1):1828.CrossRefGoogle ScholarPubMed
Ladetto, M, De Marco, F, Benedetti, F, Vitolo, U, Patti, C, Rambaldi, A, et al. Prospective, multicenter randomized GITMO/IIL trial comparing intensive (R-HDS) versus conventional (CHOP-R) chemoimmunotherapy in high-risk follicular lymphoma at diagnosis: the superior disease control of R-HDS does not translate into an overall survival advantage. Blood. 2008;111(8):4004−13.CrossRefGoogle Scholar
Schaaf, M, Reiser, M, Borchmann, P, Engert, A, Skoetz, N. High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults. Cochrane Database Syst Rev. 2012;1:CD007678.Google ScholarPubMed
Wang, B, Ren, C, Zhang, W, Ma, X, Xia, B, Sheng, Z. Intensified therapy followed by autologous stem-cell transplantation versus conventional therapy as first-line treatment of follicular lymphoma: a meta-analysis. Hematol Oncol. 2013;31(1):2933.CrossRefGoogle ScholarPubMed
Montoto, S, Canals, C, Rohatiner, AZ, Taghipour, G, Sureda, A, Schmitz, N, et al. Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study. Leukemia. 2007;21(11):2324–31.CrossRefGoogle ScholarPubMed
Akhtari, M, Bhatt, VR, Tandra, PK, Krishnamurthy, J, Horstman, H, Dreessen, A, et al. Therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplantation in lymphoma patients. Cancer Biol Ther. 2013 1;14(12):1077–88.CrossRefGoogle ScholarPubMed
Schouten, HC, Qian, W, Kvaloy, S, Porcellini, A, Hagberg, H, Johnsen, HE, et al. High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin’s lymphoma: results from the randomized European CUP trial. J Clin Oncol. 2003;21(21):3918−27.CrossRefGoogle ScholarPubMed
Le Gouill, S, De Guibert, S, Planche, L, Brice, P, Dupuis, J, Cartron, G, et al. Impact of the use of autologous stem cell transplantation at first relapse both in naive and previously rituximab exposed follicular lymphoma patients treated in the GELA/GOELAMS FL2000 study. Haematologica. 2011;96(8):1128–35.CrossRefGoogle ScholarPubMed
Vose, JM, Bierman, PJ, Loberiza, FR, Lynch, JC, Bociek, GR, Weisenburger, DD, et al. Long-term outcomes of autologous stem cell transplantation for follicular non-Hodgkin lymphoma: effect of histological grade and Follicular International Prognostic Index. Biol Blood Marrow Transplant. 2008;14(1):3642.CrossRefGoogle ScholarPubMed
Gisselbrecht, C, Glass, B, Mounier, N, Singh Gill, D, Linch, DC, Trneny, M, et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28(27):4184–90.CrossRefGoogle ScholarPubMed
Kothari, J, Peggs, KS, Bird, A, Thomson, KJ, Morris, E, Virchis, AE, et al. Autologous stem cell transplantation for follicular lymphoma is of most benefit early in the disease course and can result in durable remissions, irrespective of prior rituximab exposure. Br J Haematol. 2014;165(3):334–40.CrossRefGoogle ScholarPubMed
Evens, AM, Vanderplas, A, LaCasce, AS, Crosby, AL, Nademanee, AP, Kaminski, MS, et al. Stem cell transplantation for follicular lymphoma relapsed/refractory after prior rituximab: a comprehensive analysis from the NCCN lymphoma outcomes project. Cancer. 2013;119(20):3662–71.CrossRefGoogle ScholarPubMed
Peters, AC, Duan, Q, Russell, JA, Duggan, P, Owen, C, Stewart, DA. Durable event-free survival following autologous stem cell transplant for relapsed or refractory follicular lymphoma: positive impact of recent rituximab exposure and low-risk Follicular Lymphoma International Prognostic Index score. Leuk Lymphoma. 2011;52(11):2124–9.CrossRefGoogle ScholarPubMed
Phipps, C, Gopal, AK, Storer, BE, Cassaday, RD, Press, OW, Till, BG, et al. Autologous transplant for relapsed follicular lymphoma: impact of pre-transplant rituximab sensitivity. Leuk Lymphoma. 2014;17:15.Google Scholar
Gopal, AK, Gooley, TA, Rajendran, JG, Pagel, JM, Fisher, DR, Maloney, DG, et al. Myeloablative I-131-tositumomab with escalating doses of fludarabine and autologous hematopoietic transplantation for adults age >/= 60 years with B cell lymphoma. Biol Blood Marrow Transplant. 2014;20(6):770−5.CrossRefGoogle ScholarPubMed
Decaudin, D, Mounier, N, Tilly, H, Ribrag, V, Ghesquières, H, Bouabdallah, K, et al. 90Y Ibritumomab tiuxetan (zevalin) combined with BEAM (Z -BEAM) conditioning regimen plus autologous stem cell transplantation in relapsed or refractory low-grade CD20-positive B-cell lymphoma. A GELA phase II prospective study. Clin Lymphoma Myeloma Leuk. 2011;11(2):212–8.CrossRefGoogle ScholarPubMed
Brown, JR, Feng, Y, Gribben, JG, Neuberg, D, Fisher, DC, Mauch, P, et al. Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission. Biol Blood Marrow Transplant. 2007;13(9):1057–65.CrossRefGoogle ScholarPubMed
Arcaini, L, Montanari, F, Alessandrino, EP, Tucci, A, Brusamolino, E, Gargantini, L, et al. Immunochemotherapy with in vivo purging and autotransplant induces long clinical and molecular remission in advanced relapsed and refractory follicular lymphoma. Ann Oncol. 2008;19(7):1331–5.CrossRefGoogle ScholarPubMed
Hicks, LK, Woods, A, Buckstein, R, Mangel, J, Pennell, N, Zhang, L, et al. Rituximab purging and maintenance combined with auto-SCT: long-term molecular remissions and prolonged hypogammaglobulinemia in relapsed follicular lymphoma. Bone Marrow Transplant. 2009;43(9):701–8.CrossRefGoogle ScholarPubMed
Brugger, W, Hirsch, J, Grunebach, F, Repp, R, Brossart, P, Vogel, W, et al. Rituximab consolidation after high-dose chemotherapy and autologous blood stem cell transplantation in follicular and mantle cell lymphoma: a prospective, multicenter phase II study. Ann Oncol. 2004;15(11):1691–8.CrossRefGoogle ScholarPubMed
Morschhauser, F, Recher, C, Milpied, N, Gressin, R, Salles, G, Brice, P, et al. A 4-weekly course of rituximab is safe and improves tumor control for patients with minimal residual disease persisting 3 months after autologous hematopoietic stem-cell transplantation: results of a prospective multicenter phase II study in patients with follicular lymphoma. Ann Oncol. 2012;23(10):2687–95.CrossRefGoogle ScholarPubMed
Pettengell, R, Schmitz, N, Gisselbrecht, C, Smith, G, Patton, WN, Metzner, B, et al. Rituximab purging and/or maintenance in patients undergoing autologous transplantation for relapsed follicular lymphoma: a prospective randomized trial from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2013;31(13):1624–30.CrossRefGoogle ScholarPubMed
Hari, P, Carreras, J, Zhang, MJ, Gale, RP, Bolwell, BJ, Bredeson, CN, et al. Allogeneic transplants in follicular lymphoma: higher risk of disease progression after reduced-intensity compared to myeloablative conditioning. Biol Blood Marrow Transplant. 2008;14(2):236–45.CrossRefGoogle ScholarPubMed
Auer, RL, MacDougall, F, Oakervee, HE, Taussig, D, Davies, JK, Syndercombe-Court, D, et al. T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies. Br J Haematol. 2012;157(5):580−5.CrossRefGoogle ScholarPubMed
Shea, T, Johnson, J, Westervelt, P, Farag, S, McCarty, J, Bashey, A, et al. Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901. Biol Blood Marrow Transplant. 2011;17(9):1395–403.CrossRefGoogle ScholarPubMed
Khouri, IF, Champlin, RE. Nonmyeloablative allogeneic stem cell transplantation for non-hodgkin lymphoma. Cancer J. 2012;18(5):457–62.CrossRefGoogle ScholarPubMed
Mortensen, BK, Petersen, SL, Kornblit, B, Andersen, PK, Braendstrup, P, Andersen, NS, et al. Single-institution long-term outcomes for patients receiving nonmyeloablative conditioning hematopoeitic cell transplantation for chronic lymphocytic leukemia and follicular lymphoma. Eur J Haematol. 2012;89(2):151–9.CrossRefGoogle ScholarPubMed
Abou-Nassar, KE, Stevenson, KE, Antin, JH, McDermott, K, Ho, VT, Cutler, CS, et al. (90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphoma. Bone Marrow Transplant. 2011;46(12):1503–9.CrossRefGoogle ScholarPubMed
Freytes, CO, Zhang, MJ, Carreras, J, Burns, LJ, Gale, RP, Isola, L, et al. Outcome of lower-intensity allogeneic transplantation in non-Hodgkin lymphoma after autologous transplantation failure. Biol Blood Marrow Transplant. 2012;18(8):1255–64.CrossRefGoogle ScholarPubMed
Cohen, S, Kiss, T, Lachance, S, Roy, DC, Sauvageau, G, Busque, L, et al. Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity. Biol Blood Marrow Transplant. 2012;18(6):951−7.CrossRefGoogle ScholarPubMed
Crocchiolo, R, Castagna, L, Furst, S, El-Cheikh, J, Faucher, C, Oudin, C, et al. Tandem autologous-allo-SCT is feasible in patients with high-risk relapsed non-Hodgkin’s lymphoma. Bone Marrow Transplant. 2013;48(2):249–52.CrossRefGoogle ScholarPubMed
van Besien, K, Loberiza, FR Jr., Bajorunaite, R, Armitage, JO, Bashey, A, Burns, LJ, et al. Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. Blood. 2003;102(10):3521–9.CrossRefGoogle ScholarPubMed
Ingram, W, Devereux, S, Das-Gupta, EP, Russell, NH, Haynes, AP, Byrne, JL, et al. Outcome of BEAM-autologous and BEAM-alemtuzumab allogeneic transplantation in relapsed advanced stage follicular lymphoma. Br J Haematol. 2008;141(2):235–43.CrossRefGoogle ScholarPubMed
Tomblyn, MR, Ewell, M, Bredeson, C, Kahl, BS, Goodman, SA, Horowitz, MM, et al. Autologous versus reduced-intensity allogeneic hematopoietic cell transplantation for patients with chemosensitive follicular non-Hodgkin lymphoma beyond first complete response or first partial response. Biol Blood Marrow Transplant. 2011;17(7):1051–7.CrossRefGoogle ScholarPubMed
Delgado, J, Canals, C, Attal, M, Thomson, K, Campos, A, Martino, R, et al. The role of in vivo T-cell depletion on reduced-intensity conditioning allogeneic stem cell transplantation from HLA-identical siblings in patients with follicular lymphoma. Leukemia. 2011;25(3):551−5.CrossRefGoogle ScholarPubMed
Noriega, V, Kaur, H, Devereux, S, Byrne, J, Marcus, R, Haynes, A, et al. Long-term follow-up of BEAM-autologous and BEAM-alemtuzumab allogeneic stem cell transplantation in relapsed advanced stage follicular lymphoma. Leuk Res. 2014;38(7):737−43.CrossRefGoogle ScholarPubMed
Thomson, KJ, Morris, EC, Milligan, D, Parker, AN, Hunter, AE, Cook, G, et al. T-cell-depleted reduced-intensity transplantation followed by donor leukocyte infusions to promote graft-versus-lymphoma activity results in excellent long-term survival in patients with multiply relapsed follicular lymphoma. J Clin Oncol. 2010;28(23):3695–700.CrossRefGoogle ScholarPubMed
Robinson, SP, Canals, C, Luang, JJ, Tilly, H, Crawley, C, Cahn, JY, et al. The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. Bone Marrow Transplant. 2013;48(11):1409−14.CrossRefGoogle ScholarPubMed

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