Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-26T19:10:38.446Z Has data issue: false hasContentIssue false

Chapter 18 - Neurodegenerative Diseases in Elders

Published online by Cambridge University Press:  11 July 2020

Kim A. Collins
Affiliation:
LifePoint Inc, South Carolina
Roger W. Byard
Affiliation:
University of Adelaide
Get access

Summary

The fact that Alzheimer dementia is the sixth leading cause of death in adults aged 65 years or older in the United States [1] requires that the forensic pathologist, clinician, and medicolegal death investigator be familiar with the clinical manifestations of dementia and the appropriate postmortem evaluation for definitive classification. It has been shown that dementia, in general, is under-reported on death certificates [2], and its contribution to death may not be well-recognized.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Heron, M.. Deaths: leading causes for 2016. Natl Vital Stat Rep 2018; 67: 177.Google Scholar
James, B. D., Leurgans, S. E., Hebert, L. E. et al. Contribution of Alzheimer disease to mortality in the United States. Neurology 2014; 82: 16.Google Scholar
Hebert, L. E., Weuve, J., Scherr, P. A. et al. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology 2013; 80: 1778–83.Google Scholar
Goldman, J. S., Farmer, J. M., Van Deerlin, V. M. et al. Frontotemporal dementia: genetics and genetic counseling dilemmas. Neurologist 2004; 10: 227–34.Google Scholar
Adelman, A. M., Daly, M. P.. Initial evaluation of the patient with suspected dementia. Am Fam Physician 2005; 71: 1745–50.Google ScholarPubMed
Reichard, R. R., Parisi, J. E.. A pragmatic approach to the postmortem neuropathological diagnosis of dementia. Acad Forensic Pathol 2012; 2: 29.CrossRefGoogle Scholar
Ellison, D., Love, S., Chimelli, L. et al. Dementias. In Ellison, D., Love, S., Chimelli, L. et al., eds. Neuropathology. A Reference Text of CNS Pathology. 3rd edn. Edinburgh, Mosby; 2013: pp. 609–58.Google Scholar
Crain, B. J.. The autopsy in cases of Alzheimer disease and other dementias. In Collins, K. A., ed. Autopsy Performance & Reporting. 3rd edn. Northfield, College of American Pathologists; 2017: pp. 219–25.Google Scholar
Thal, D. R., Rϋb, U., Orantes, M. et al. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002; 58: 1791–800.CrossRefGoogle ScholarPubMed
Braak, H., Alafuzoff, I., Arzberger, T. et al. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 2006; 112: 389404.Google Scholar
Montine, T. J., Phelps, C. H., Beach, T. G. et al. National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 2012; 123: 111.Google Scholar
McKeith, I. G., Dickson, D. W., Lowe, J. et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863–72.CrossRefGoogle ScholarPubMed
Revesz, T., Clark, H. B., Holton, J. L. et al. Extrapyramidal diseases of movement. In Love, S., Perry, A., Ironside, J. et al., eds. Greenfield’s Neuropathology. 9th edn. Boca Raton, CRC Press; 2015: pp. 740–98.Google Scholar
Cairns, N. J., Bigio, E. H., McKenzie, I. R. et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 2007; 114: 522.CrossRefGoogle Scholar
McKee, A. C., Stern, R. A., Nowinski, C. J., et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136: 4364.Google Scholar
Loy, C. T., Schofield, P. R., Turner, A. M. et al. Genetics of dementia. Lancet 2014; 383: 828–40.CrossRefGoogle ScholarPubMed
Kapasi, A., DeCarli, C., .Schneider, J. A. Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol 2017; 134: 171–86.Google Scholar
Power, M. C., Mormino, E., Soldan, A. et al. Combined neuropathological pathways account for age-related risk of dementia. Ann Neurol 2018; 84: 1022.CrossRefGoogle ScholarPubMed
Cykowski, M. D., Powell, S. Z., Schulz, P. E. et al. Hippocampal sclerosis in older patients: practical examples and guidance with a focus on cerebral age-related TDP-43 with sclerosis. Arch Pathol Lab Med 2017; 141: 1113–26.Google Scholar
Crary, J. F., Trojanowski, J. Q., Schneider, J. A. et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 2014; 128: 755–66.CrossRefGoogle Scholar
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q. et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 2019; 142: 1503–27CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×