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35 - Acidosis and alkalosis

from Section 4 - Specific conditions associated with fetal and neonatal brain injury

Published online by Cambridge University Press:  12 January 2010

By
Ronald S. Cohen
Edited by
David K. Stevenson ,
William E. Benitz ,
Philip Sunshine ,
Susan R. Hintz  and
Maurice L. Druzin
David K. Stevenson
Affiliation:
Stanford University School of Medicine, California
William E. Benitz
Affiliation:
Stanford University School of Medicine, California
Philip Sunshine
Affiliation:
Stanford University School of Medicine, California
Susan R. Hintz
Affiliation:
Stanford University School of Medicine, California
Maurice L. Druzin
Affiliation:
Stanford University School of Medicine, California
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Summary

Introduction

As part of normal homeostasis, the pH of arterial blood is fairly tightly controlled by normal physiologic processes. Healthy adults maintain a reasonably stable pH, ranging from 7.35 to 7.45, and the initial pH after birth can range from 7.11 to 7.36. Acidosis (low pH) and alkalosis (high pH) occur commonly when there are disturbances of the body's normal physiology. This can result from either a pathologic process or medical interventions. When they are due to, or associated with, a pathologic process, the abnormal pH may be blamed for any long-term consequences of that event. Similarly, when a medication or treatment results in an abnormal pH, any long-term consequences may be assigned to that intervention. In both situations, it is not clear whether the underlying physiologic disturbance is responsible for the adverse long-term outcome, or whether the abnormal pH played a role, and if so, how important that role may have been.

Acidosis

Acidosis is known to accompany ischemia, and has been used as a marker for tissue hypoxia and damage. However, it is unclear whether or not acidosis per se is a cause of injury. To examine this issue, we need to separate the two clinical subtypes of acidosis – respiratory and metabolic.

Respiratory acidosis

Respiratory acidosis occurs when carbon dioxide (CO2), produced by metabolism, builds up in the body and dissolves in the bloodstream.

Type
Chapter
Information
Fetal and Neonatal Brain Injury , pp. 402 - 408
Publisher: Cambridge University Press
Print publication year: 2009

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